1993
DOI: 10.1006/bbrc.1993.1057
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Partial Nucleotide Sequence of the Xanthomonas Maltophilia Chorionic Gonadotropin-Like Receptor

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Cited by 8 publications
(7 citation statements)
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“…Because the 1l,500-Da site in our studies was CG specific and had a high affinity, it is not likely a fragment from the 170,500-Da binding site. It is also of interest to note that the partial 342-base pair sequence cloned from X. maltophilia (21) correlates to just over 11,000 Daltons, similar in size to our reported CG-specific site and, therefore, may be a complete sequence for this receptor. The hCG-binding affinities estimated in our study for the large-molecular-weight LH/CG-binding site of X. maltophilia was about 125-fold lower than for the smallmolecular-weight site.…”
Section: Discussionsupporting
confidence: 83%
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“…Because the 1l,500-Da site in our studies was CG specific and had a high affinity, it is not likely a fragment from the 170,500-Da binding site. It is also of interest to note that the partial 342-base pair sequence cloned from X. maltophilia (21) correlates to just over 11,000 Daltons, similar in size to our reported CG-specific site and, therefore, may be a complete sequence for this receptor. The hCG-binding affinities estimated in our study for the large-molecular-weight LH/CG-binding site of X. maltophilia was about 125-fold lower than for the smallmolecular-weight site.…”
Section: Discussionsupporting
confidence: 83%
“…Further characterization of the LH/CG sites on X. maltophilia will be required if we are to understand their evolutionary relationship with mammals, define the unique structure of the CG-specific binding site, and investigate the possibility of therapeutic treatments. Although a 342-base pair DNA sequence cloned from X. maltophilia with 73% homology to portions of the human receptor is likely a portion of a bacterial LH/CG-binding site (21), the sequence is incomplete and could be for either the high-or lowaffinity binding site. In addition, neither the LH/CG-nor CG-specific binding sites, initially identified using binding assays to whole bacteria, have been isolated from the bacterial membrane or assigned a molecular weight.…”
mentioning
confidence: 99%
“…Little is known of the genetic structure of S. maltophilia. A gene of 1,362 bp encoding a 48.5-kDa chorionic gonadotrophin-like hormone has been sequenced (164,166). This hormone bears an immunological resemblance to human chorionic gonadotrophin (hCG) (163, 165) (see below).…”
Section: Geneticsmentioning
confidence: 99%
“…Following the isolation of S. maltophilia from the ovarian fluid of a sow, Richert and Ryan (353) and others (2) demonstrated that the bacterium was capable of binding hCG. Subsequently, it was shown that an hCG-like protein (xCG) from S. maltophilia has a high degree of homology with the ␤ subunit of hCG (164). An autocrine and/or paracrine function for xCG has been suggested following observations that when added to growth media, it (and hCG) causes changes in both the cell growth cycle and bacterial morphology (65).…”
Section: Human Carriagementioning
confidence: 99%
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