Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate

Buendía-Jiménez, J.A.; Muñoz-Guzmán, M.A.; Vega-Lopez, M. A.; Cuenca-Verde, C.; Martínez-Labat, J.P.; Cuéllar-Ordaz, Jorge Alfredo; Arenzana-Seisdedos, Fernando

doi:10.1016/j.vetpar.2015.04.019

Cited by 8 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we found more eosinophils in the abomasal fundic mucosa of resistant lambs, and this difference was not found for the pyloric region. Other studies found similar results comparing H. contortus‐ resistant and susceptible sheep 14,45 . The enhanced recruitment of effector cells in the abomasal fundic mucosa may be important for the effective control of parasitic infection, as H. contortus has a prominent tropism for this abomasal region, especially the immature forms, which are practically absent in the pyloric region 46,47 …”

Section: Discussionmentioning

confidence: 64%

“…Other studies found similar results comparing H. contortus-resistant and susceptible sheep. 14,45 The enhanced recruitment of effector cells in the abomasal fundic mucosa may be important for the effective control of parasitic infection, as H. contortus has a prominent tropism for this abomasal region, especially the immature forms, which are practically absent in the pyloric region. 46,47 An effective eosinophil and mast cell response against parasites is strictly dependent on IgE antibodies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes

Toscano

Okino

Santos

et al. 2020

Parasite Immunology

View full text Add to dashboard Cite

Haemonchus contortus, the most pathogenic sheep parasite, is the major limiting factor for sheep farming in tropical countries, including in Brazilian territory. 1-4 As chemical control is the main tool for combating this parasite, the widespread multiple resistance of H. contortus to anthelmintics highlights the urgent need for alternative control measures, such as the selective breeding for parasite resistance or development of immune-related therapeutics. 5-8 Therefore, better understanding of the immuno-genetic mechanisms underlying this resistance is required. Immunity against helminths depends on cellular adaptive responses, through participation of T-helper lymphocytes (Th, CD4+), which are functionally grouped into two subpopulations: Th1,

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes

Toscano

Okino

Santos

et al. 2020

Parasite Immunology

View full text Add to dashboard Cite

show abstract

Effect of norepinephrine treatment on Haemonchus contortus and its excretory products

Chen

et al. 2019

Parasitol Res

View full text Add to dashboard Cite

Regulatory effect of Balanites aegyptiaca ethanol extract on oxidant/antioxidant status, inflammatory cytokines, and cell apoptosis gene expression in goat abomasum experimentally infected with Haemonchus Contortus

Sedky,

Abd El-Aziz,

Nasr

et al. 2024

Trop Anim Health Prod

View full text Add to dashboard Cite

This experiment aimed to assess the regulatory effects of treatment with Balanites aegyptiaca fruit ethanol extract (BA-EE) on oxidant/antioxidant status, anti-inflammatory cytokines, and cell apoptosis gene expression in the abomasum of Haemonchus contortus–infected goats. Twenty goat kids were assigned randomly to four equal groups: (G1) infected-untreated, (G2) uninfected-BA-EE-treated, (G3) infected-albendazole-treated, (G4) infected-BA-EE-treated. Each goat in (G1), (G3), and (G4) was orally infected with 10,000 infective third-stage larvae. In the fifth week postinfection, single doses of albendazole (5 mg/kg.BW) and BA-EE (9 g/kg.BW) were given orally. In the ninth week postinfection, the animals were slaughtered to obtain abomasum specimens. The following oxidant/antioxidant markers were determined: malondialdehyde (MDA), glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT). The mRNA gene expression of cytokines (IL-3, IL-6, IL-10, TNF-α) and cell apoptosis markers (Bax, Bcl-2) were estimated. (G1) showed significantly reduced GSH content and GST and SOD activities but a markedly increased MDA level. (G3) and (G4) revealed a markedly lower MDA level with pronouncedly elevated GSH, SOD, and GST levels. The antioxidant properties of BA-EE were superior to those of albendazole. The mRNA gene expressions of IL-3, IL-6, IL-10, TNF-α, and Bax-2 were upregulated in (G1) but downregulated in (G3) and (G4). Bcl-2 and Bcl-2/Bax ratio expression followed a reverse course in the infected and both treated groups. We conclude that BA-EE treatment has a protective role in the abomasum of H. contortus–infected goats. This could be attributed to its antioxidant properties and ability to reduce pro-inflammatory cytokines and cell apoptosis.

show abstract

Partial protection and abomasal cytokine expression in sheep experimentally infected with Haemonchus contortus and pre-treated with Taenia hydatigena vesicular concentrate

Cited by 8 publications

References 28 publications

Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes

Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes

Effect of norepinephrine treatment on Haemonchus contortus and its excretory products

Regulatory effect of Balanites aegyptiaca ethanol extract on oxidant/antioxidant status, inflammatory cytokines, and cell apoptosis gene expression in goat abomasum experimentally infected with Haemonchus Contortus

Contact Info

Product

Resources

About