Partial pulpotomy on caries‐free teeth using enamel matrix derivative or calcium hydroxide: a randomized controlled trial

Kiatwateeratana, T.; Kintarak, Sompid; Piwat, Supatcharin; Chankanka, Oitip; Kamaolmatyakul, S.; Thearmontree, Angkana

doi:10.1111/j.1365-2591.2009.01552.x

Cited by 40 publications

(38 citation statements)

References 21 publications

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“…Kiatwateeratana ve arkadaşlarının 38 yaptıkları çalış-mada küçük azı dişe parsiyel pulpotomi uygulanarak EMD ve kalsiyum hidroksit ile tedavileri yapılarak histolojik, radyografik ve postoperatif olarak karşılaştırmala-rı yapılmıştır. İlk 2 hafta EMD ile tedavi edilen dişlerde belirgin bir şekilde daha az hipersensitivite görülmüştür.…”

Diş hekimliğinde Emdogain

Özerol¹,

Yilmaz²,

Bodrumlu³

2014

Acta Odontol Turc

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ÖZETBir mine matriks türevi olan Emdogain (EMD), dişi destekleyen dokuların rejenerasyonunda klinik olarak kullanılan bir materyaldir. EMD, yüzey detoksifikasyonu, demineralizasyonu ve kollajen liflerin açığa çıkması ve biyouyumlu bir yüzey oluşturulmasını sağlamaktadır. EMD, alkalin fosfataz aktivitesini ve osteoblastlardaki kemik matriks proteinlerinin salınımını arttırmaktadır. Amelogeninler mezenşimal hücreleri stimüle ederek iyileşme, büyüme ve rejenerasyon için gerekli olan faktörlerin açığa çıkmalarını sağlamaktadır. Amelogenin içerikli emdogainin endodontide, periodontolojide, implantolojide ve travmatolojide kemik ve yara iyileşmesi ve vital pulpa tedavilerinde kullanı-larak doku rejenerasyonlarında alternatif bir uygulama metodu olduğu görülmüştür. ANAHTAR KELİMELER: Amelin; amelogenin; emdogain; kalsiyum hidroksit; mine matriks proteinleri; rejenerasyon KAYNAK GÖSTERMEK İÇİN: Özerol NB, Yılmaz NA, Bodrumlu E.

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Diş hekimliğinde Emdogain

Özerol¹,

Yilmaz²,

Bodrumlu³

2014

Acta Odontol Turc

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“…Clinical trials have shown that partially pulpotomized EMD gel-treated teeth had significantly less tooth hypersensitivity compared to Ca(OH) 2 -treated [12] with a positive effect on wound healing/new tissue and hard tissue formation [13]. …”

Section: Introductionmentioning

confidence: 99%

Enamel Matrix Derivative Promote Primary Human Pulp Cell Differentiation and Mineralization

Riksen

Landin

Reppe

et al. 2014

IJMS

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Enamel matrix derivative (EMD) has been found to induce reactive dentin formation; however the molecular mechanisms involved are unclear. The effect of EMD (5–50 μg/mL) on primary human pulp cells were compared to untreated cells and cells incubated with 10−8 M dexamethasone (DEX) for 1, 2, 3, 7, and 14 days in culture. Expression analysis using Affymetrix microchips demonstrated that 10 μg/mL EMD regulated several hundred genes and stimulated the gene expression of proteins involved in mesenchymal proliferation and differentiation. Both EMD and DEX enhanced the expression of amelogenin (amel), and the dentinogenic markers dentin sialophosphoprotein (DSSP) and dentin matrix acidic phosphoprotein 1 (DMP1), as well as the osteogenic markers osteocalcin (OC, BGLAP) and collagen type 1 (COL1A1). Whereas, only EMD had effect on alkaline phosphatase (ALP) mRNA expression, the stimulatory effect were verified by enhanced secretion of OC and COL1A from EMD treated cells, and increased ALP activity in cell culture medium after EMD treatment. Increased levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant proteins (MCP-1) in the cell culture medium were also found. Consequently, the suggested effect of EMD is to promote differentiation of pulp cells and increases the potential for pulpal mineralization to favor reactive dentine formation.

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“…These cells join together to form a network [7]. All pulp vessels have very thin walls due to muscularis mucosa reduction.…”

Section: Core Pulp -Cell-rich Zonementioning

confidence: 99%

“…Attempts are also made to cover wounded and open pulp with bonding systems [14,18], glass ionomer cement [8] or enamel matrix proteins [7]. The effects are debatable, cause inflammation, including necrosis, and no dentin bridge has been found [12,15,16].…”

Section: Age-related Changes In Endodontiummentioning

confidence: 99%

“…It is formed by odontoblast-like cells as a result external stimulation with preparations having odontotropic effect after the destruction of the odontoblasts. If the pulp damage was severe, dentin is formed by fibroblasts as a dentin bridge of non-tubular structure j [7]. Odontotropic preparations used in the daily dental practice as a direct pulp capping include calcium hydroxide and MTA (Mineral troxide aggregate) [9,11].…”

Section: Age-related Changes In Endodontiummentioning

confidence: 99%

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