1977
DOI: 10.1016/0003-9861(77)90493-3
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Partial purification and characterization of citrate synthase from Dictyostelium discoideum

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1979
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Cited by 11 publications
(3 citation statements)
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“…Chen, unpublished). Previous studies have showed that citrate synthase specific activity is present throughout development (Porter and Wright, 1977).…”
Section: Discussionmentioning
confidence: 99%
“…Chen, unpublished). Previous studies have showed that citrate synthase specific activity is present throughout development (Porter and Wright, 1977).…”
Section: Discussionmentioning
confidence: 99%
“…PcCS showed a high homology to rat CS (65% identity), suggesting that hemin binds at the AcCoA–CoA binding site of CS. Although several inhibitors have already been reported for other eukaryotic CSs, these inhibition constants are larger than 0.1 mM (Lee et al 1997 ; Mahlen 1972 ; Porter and Wright 1977 ), indicating that hemin showed a 10-times higher inhibitory effect. Furthermore, protoporphyrin IX slightly inhibited PcCS at a concentration more than 10 times the inhibitory concentration of hemin (data not shown), suggesting that the binding and inhibition of heme to PcCS requires the presence of iron ions in the tetrapyrrol ring.…”
Section: Resultsmentioning
confidence: 95%
“…Very little is known about the oxidative segment of this process. Citrate synthase (EC 4.1.3.7) has been partially purified and characterized (Porter & Wright, 1977), and the respiratory chain of late-exponentialphase amoebae has been examined and its components shown to be similar to other eukaryotic systems (Erikson & Ashworth, 1969). In addition, several enzymes associated with the chain have been studied (Takeuchi, 1960).…”
mentioning
confidence: 99%