Partial reinforcement across trials impairs escape performance but spares place learning in the water maze

Devan, Bryan D.; Stouffer, Eric M.; Petri, Herbert L.; McDonald, Robert J.; Olds, James L.

doi:10.1016/s0166-4328(02)00294-2

Cited by 21 publications

(14 citation statements)

References 26 publications

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“…Analysis of the probe trial data were conducted on the first 30 sec of the probe trial only, because a bin analysis (Devan et al, 2003) at 30-sec intervals revealed that nearly all of the animals rapidly extinguished any preference for the quadrant where the platform had been located after 30 sec. As in the acquisition analyses, SAL and PHEN1 were combined into one group (CON) for purposes of statistical analysis, since comparisons of the two groups revealed no significant statistical difference.…”

Section: Discussionmentioning

confidence: 99%

The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats

Janas¹,

Cunningham²,

Duffy³

et al. 2005

Life Sciences

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Section: Discussionmentioning

confidence: 99%

The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats

Janas¹,

Cunningham²,

Duffy³

et al. 2005

Life Sciences

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“…These studies support the proposed involvement of several brain regions, including the caudate nucleus, in a spatial navigation network. In the water maze, the strength and persistence of spatial behavior is influenced by specific reinforcement contingencies Devan, Stouffer, Petri, McDonald, & Olds, 2001) that may involve the function of extrahippocampal circuits, such as a habit-based corticostriatal system (Devan, McDonald, & White, 1999;McDonald & White, 1993;Mishkin, Malamut, & Bachevalier, 1984;Mishkin & Petri, 1984;Petri & Mishkin, 1994), which has been shown to mediate spatial performance guided by salient cues late in training (Packard & McGaugh, 1996).…”

Section: Discussionmentioning

confidence: 99%

A Room with a View and a Polarizing Cue: Individual Differences in the Stimulus Control of Place Navigation and Passive Latent Learning in the Water Maze

Devan

Petri

Mishkin

et al. 2002

Neurobiology of Learning and Memory

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“…Rats were put into the pool at a randomly selected cardinal location and allowed to swim for 30 s. By tracking the rat it was possible to assign its position to one of the four pool quadrants at 1 s resolution. To characterize the temporal aspects of the probe trial behaviour, we measured the percentage of time the rat spent in each quadrant during the first three 10‐s intervals (Devan et al ., 2003).…”

Section: Experiments 2 Effects Of Peripherally Administered Cpp On Pomentioning

confidence: 99%

NMDA‐receptor blockade by CPP impairs post‐training consolidation of a rapidly acquired spatial representation in rat hippocampus

McDonald

Hong

Craig

et al. 2005

Eur J of Neuroscience

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Recent evidence suggests that N-methyl-D-aspartate (NMDA)-receptor mediated plasticity in hippocampus has a more subtle role in memory-based behaviours than originally thought. One idea is that NMDA-based plasticity is essential for the consolidation of post-training memory but not for the initial encoding or for short-term memory. To further test this idea we used a three-phase variant of the hidden goal water maze task. In the first phase, rats were pre-trained to an initial location. Next, intense, massed training was done in a 2-h interval to teach the rats to go to a new location after either an injection of the NMDA receptor antagonist (6)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or of vehicle. Finally, under drug-free conditions 24 h after new location training, a competition test was done between the original and new locations. We find that N-methyl-D-aspartate (NMDA)-receptor blockade has little or no effect on new location training. In contrast, when tested 24 h later, the strength of the trace for the new location learned during NMDA-receptor blockade was much weaker compared with the trace for the new location learned after saline injection. Further experiments showed similar effects when NMDA-receptors were blocked immediately after the new location training, suggesting that this is a memory consolidation effect. Our results therefore reinforce the notion that hippocampal NMDA-receptors participate in post-training memory consolidation but are not essential for the processes necessary to learn or retain navigational information in the short term.

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Partial reinforcement across trials impairs escape performance but spares place learning in the water maze

Cited by 21 publications

References 26 publications

The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats

The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats

A Room with a View and a Polarizing Cue: Individual Differences in the Stimulus Control of Place Navigation and Passive Latent Learning in the Water Maze

NMDA‐receptor blockade by CPP impairs post‐training consolidation of a rapidly acquired spatial representation in rat hippocampus

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