Partial Sleep Deprivation Attenuates the Positive Affective System: Effects Across Multiple Measurement Modalities

Finan, Patrick H.; Quartana, Phillip J.; Remeniuk, Bethany; Garland, Eric L.; Rhudy, Jamie L.; Hand, Matthew; Irwin, Michael R.; Smith, Michael T.

doi:10.1093/sleep/zsw017

Cited by 86 publications

(70 citation statements)

References 56 publications

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“…While the present study found only a role for NA (and not PA) in the sleep-pain relationship, previous studies with healthy adults have reported that sleep disruption impacts the inhibition of pain via the PA system, but not the NA system. 13 Developmental differences may explain the discrepancies, especially given prior pediatric findings which corroborate the importance of NA in understanding sleep and pain. In children with sickle cell disease (SCD), negative mood was found to mediate the relationship between poor sleep and high daily pain the following day {Valrie, 2008 #105}.…”

Section: Discussionmentioning

confidence: 97%

“…In healthy adult samples, interrupted sleep impacts the inhibition of pain predominantly through a decrease in PA (rather than an increase in NA). 13 The roles of positive and negative affect are less clear in the relationship between sleep and pain in children, although good quality sleep is critical to wellbeing in pediatric populations. Sufficient restorative sleep is essential to children’s optimal physical, social, emotional and cognitive functioning{Long, 2008 #68}.…”

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confidence: 99%

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Sleep Quality, Affect, Pain, and Disability in Children With Chronic Pain: Is Affect a Mediator or Moderator?

Evans

Djilas

Seidman

et al. 2017

The Journal of Pain

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Sleep problems have been identified as a potential antecedent of chronic pain and pain-related disability in pediatric populations. In adult studies, affect has been implicated in these relationships. This study sought to better understand the relationships between sleep quality, negative and positive affect and pain and functioning in children with chronic pain. Participants included 213 children and adolescents (aged 7–17) presenting to a tertiary pain clinic with chronic pain. Children completed questionnaires measuring sleep quality, positive and negative affect, pain intensity, and functional disability. Results indicated that 74% of children reported disordered sleeping and that poor sleep quality was significantly associated with increased pain, disability, negative affect, and decreased positive affect. Our hypotheses were partially supported, with negative affect (but not positive affect) mediating the relationship between poor sleep and increased pain; and both positive and negative affect mediating the relationship between poor sleep and increased functional disability. There was no evidence for affect as a moderator. This study adds to the growing literature demonstrating the impact of poor sleep quality on children’s pain and functioning, highlighting the need to develop further longitudinal research to confirm the causal roles of these variables.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Sleep Quality, Affect, Pain, and Disability in Children With Chronic Pain: Is Affect a Mediator or Moderator?

Evans

Djilas

Seidman

et al. 2017

The Journal of Pain

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“…First, the small sample size used in the present study, coupled with the high number of a priori tests, weakens the strength of inference. Second, previous studies using the FA protocol over two nights showed it maximally induced hyperalgesia (Iacovides, George, Kamerman, & Baker, ) and diminished pain inhibition (Finan et al, ; Smith et al, ). In the present study, we used a smaller time window (one night) than previously reported, which might account for our lack of robust hyperalgesia findings.…”

Section: Discussionmentioning

confidence: 96%

“…The present study used a previously described sleep disruption protocol (see Finan et al, , for a complete description). We chose sleep disruption (i.e., FA) based on previous work suggesting that this type of paradigm results in greater impairment of endogenous pain modulation compared to sleep restriction (Smith, Edwards, Mccann, & Haythornthwaite, ).…”

Section: Methodsmentioning

confidence: 99%

Individual differences in pain sensitivity are associated with cognitive network functional connectivity following one night of experimental sleep disruption

Letzen

Remeniuk

Smith

et al. 2019

Human Brain Mapping

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Previous work suggests that sleep disruption can contribute to poor pain modulation. Here, we used experimental sleep disruption to examine the relationship between sleep disruption-induced pain sensitivity and functional connectivity (FC) of cognitive networks contributing to pain modulation. Nineteen healthy individuals underwent two counterbalanced experimental sleep conditions for one night each: uninterrupted sleep versus sleep disruption. Following each condition, participants completed functional MRI including a simple motor task and a noxious thermal stimulation task. Pain ratings and stimulus temperatures from the latter task were combined to calculate a pain sensitivity change score following sleep disruption. This change score was used as a predictor of simple motor task FC changes using bilateral executive control networks (RECN, LECN) and the default mode network (DMN) masks as seed regions of interest (ROIs). Increased pain sensitivity after sleep disruption was positively associated with increased RECN FC to ROIs within the DMN and LECN (F (4,14) = 25.28, pFDR = 0.05). However, this pain sensitivity change score did not predict FC changes using LECN and DMN masks as seeds (pFDR > 0.05). Given that only RECN FC was associated with sleep loss-induced hyperalgesia, findings suggest that cognitive networks only partially contribute to the sleep-pain dyad.

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“…This is noteworthy, considering that sleep restriction is associated with negative mood changes (Haack & Mullington, ; Simon et al, ) and that negative mood may mediate part of the relationship between poor sleep and pain, although to date, these findings only pertain to fibromyalgia patients (O'Brien et al, ). Another experimental study, however, suggested that sleep disturbance has a stronger influence on the positive affective system relative to its effect on the negative affective system (Finan et al, ). It is likely that nocebo manipulates the latter.…”

Section: Discussionmentioning

confidence: 99%

Sleep restriction does not potentiate nocebo‐induced changes in pain and cortical potentials

Ree

Nilsen

Knardahl

et al. 2019

European Journal of Pain

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Background The increased pain sensitivity following reduced sleep may be related to changes in cortical processing of nociceptive stimuli. Expectations shape pain perception and can inhibit (placebo) or enhance (nocebo) pain. Sleep restriction appears to enhance placebo responses; however, whether sleep restriction also affects nocebo responses remains unknown. The aim of the present study was to determine whether sleep restriction facilitates nocebo‐induced changes in pain and pain‐evoked cortical potentials. Methods In an experimental study with a crossover design, the sensitivity to electrically induced pain was determined in 53 nurses under two sleep conditions, after habitual sleep and after two consecutive nights at work. Nocebo was induced by conditioning one‐third of the pain stimuli. Pain‐elicited cortical event‐related potentials were recorded by electroencephalography (EEG). Data were analysed both in the time domain (N2P2 amplitude) and in the time–frequency domain (ERP magnitude). Sleepiness and vigilance were also assessed. Results Both nocebo alone and sleep restriction alone increased the sensitivity to electrically induced pain. However, no interaction effect was found. Moreover, the magnitude of the pain‐elicited responses increased after sleep restriction and decreased after nocebo expectation, suggesting that nocebo is probably not an underlying mechanism for the commonly observed hyperalgesia induced by sleep restriction. Conclusions The present work addresses whether sleep restriction, known to increase the sensitivity of the pain system, facilitates nocebo‐induced hyperalgesia. Our findings suggest that this is not the case, indicating that the increased sensitivity of the pain system following nocebo and sleep restriction are mediated by different cortical mechanisms.

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Partial Sleep Deprivation Attenuates the Positive Affective System: Effects Across Multiple Measurement Modalities

Abstract: The present findings, observed across multiple measures of affective function, suggest that sleep continuity disruption has a stronger influence on the positive affective system relative to the negative affective affective system.

Cited by 86 publications

References 56 publications

Sleep Quality, Affect, Pain, and Disability in Children With Chronic Pain: Is Affect a Mediator or Moderator?

Sleep Quality, Affect, Pain, and Disability in Children With Chronic Pain: Is Affect a Mediator or Moderator?

Individual differences in pain sensitivity are associated with cognitive network functional connectivity following one night of experimental sleep disruption

Sleep restriction does not potentiate nocebo‐induced changes in pain and cortical potentials

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