Participação Dos Mastócitos No Reparo Tecidual E Em Lesões Inflamatórias Bucais – Uma Revisão De Literatura

Abstract

Mast cells (MCs) are mobile cells that contain granules, derived from bone marrow and are widely distributed in tissues actively participating in immune responses. The involvement of these cells has been demonstrated in the inflammation, fibrosis and angiogenesis, in which they act through their secretory products. The purpose of this literature review is to address the involvement of MCs in biological phenomena that comprise the context of tissue repair, such as vasodilation, angiogenesis and fibrosis, with emphasis on the characterization of the profile of these cells in inflammatory lesions mouth. Although few studies contemplate the participation of MCs in oral lesions, some others have shown that these cells are involved in the pathogenesis of periapical lesions, aphthous ulcers, odontogenic cysts, among others. The advancement of knowledge about the mechanism of action of these cells, has stimulated the development of therapies whose chief aim is the regulation of chemical mediators released by mast cells. Therefore, it is hoped that through further investigations, inflammatory disorders of the oral cavity and other conditions that display interstitial MCs,might be better understood, mainly concern to MCs biological behavior.

Tissue repair under the influence of plasma jet and other biomodulator therapies - state of the art

“…An example that illustrates that situation is the degranulation of mastocytes with histamine, serotonin, tryptase and pro-inflammatory cytokines releasing (Pereira et al, 2010) (Figure 3). Mastocytes play an important role in the tissue repair since they synthesize chemical mediators that promote neo-angiogenesis, amplify vasodilation and contribute to the migration of more inflammatory cells at the site of the wound (Correia & Medrado, 2013;Mendonça & Coutinho-Netto, 2009). Many chemical mediators started to be synthesized by inflammatory cells and by mastocytes, macrophages and fibroblasts.…”