Particle, Powder, and Compact Characterization

Amidon, Gregory E.; Secreast, Pamela J.; Mudie, Deanna M.

doi:10.1016/b978-0-444-53242-8.00008-4

Cited by 45 publications

(21 citation statements)

References 62 publications

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“…50 MPa, 150 MPa and 200 MPa) representing a relatively wide range of compaction behavior were utilized. Tensile strength values in excess of 1 MPa are typically desired for tablets to withstand stress during their lifetime ( 25 ). Among the silicates tested, only Neusilin® US2 and Neusilin® UFL2 could produce tablets with a tensile strength of ≥1 MPa under all three compression pressures used, while Zeopharm® 600 exhibited high tensile strengths at compression pressures of 150 and 250 MPa, which were comparable to that of Neusilin® US2 and Neusilin® UFL2.…”

Section: Resultsmentioning

confidence: 99%

Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates

Gumaste

Pawlak

Dalrymple³

et al. 2013

Pharm Res

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PurposeTo compare six commonly available silicates for their suitability to develop tablets by adsorbing components of liquid lipid-based drug delivery systems.MethodsThe tabletability of Aerosil® 200, Sipernat® 22, Sylysia® 350, Zeopharm® 600, Neusilin® US2 and Neusilin® UFL2 were studied by compressing each silicate into tablets in the presence of 20% microcrystalline cellulose and measuring the tensile strength of tablets produced. Three components of lipid based formulations, namely, Capmul® MCM EP (glycerol monocaprylocaprate), Captex® 355 EP/NF (caprylic/capric triglycerides) and Cremophor® EL (PEG-35 castor oil), were adsorbed individually onto the silicates at 1:1 w/w, and the mixtures were then compressed into tablets. The SEM photomicrographs of neat silicates and their 1:1 w/w mixtures (also 1:2 and 1:3 for Neusilin® US2 and Neusilin® UFL2) with one of the liquids (Cremophor® EL) were recorded.ResultsNeat Aerosil® 200, Sipernat® 22 and Sylysia® 350 were non-tabletable to the minimum acceptable tensile strength of 1 MPa, and they were also non-tabletable in presence of liquid. While Zeopharm® 600, Neusilin® US2 and Neusilin® UFL2 were tabletable without the addition of liquids, only Neusilin® US2 retained acceptable tabletability with 1:1 liquid. The SEM images of silicate-liquid mixtures indicated that, except for Neusilin® US2, much of the adsorbed liquid distributed primarily at the surface of particles rather than inside pores, which hindered their compaction into tablets.ConclusionAmong the six silicates studied, Neusilin® US2 was the only silicate able to produce tablets with acceptable tensile strength in presence of a lipid component at 1:1 w/w ratio due to the fact that the liquid was mostly adsorbed into the pores of the silicate rather than at the surface.

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Section: Resultsmentioning

confidence: 99%

Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates

Gumaste

Pawlak

Dalrymple³

et al. 2013

Pharm Res

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“…age during packing and distribution (5)(6)(7). In high drug load tablet formulations, excipients cannot completely circumvent the poor compression properties of the active pharmaceutical ingredient (API).…”

Section: Faculty Of Pharmacy University Of Ljubljana 1000 Ljubljana mentioning

confidence: 99%

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

2016

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Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients # Nanoindentation allows quantitative determination of a material's response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision. This review highlights the application of nanoindentation for mechanical characterization of pharmaceutical materials in the preformulation phase (primary investigation of crystalline active ingredients and excipients). With nanoindentation, mechanical response can be assessed with respect to crystal structure. The technique is valuable for mechanical screening of a material at an early development phase in order to predict and better control the processes in which a material is exposed to stress such as milling and compression.

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“…Where, D t = tapped density M= mass of the blend Vt = Tapped volume Compressibility index. The compressibility index of the Prednisolone was determined by the Carr's compressibility index with the help of bulk density and tapped density value using the following formula [20].…”

Section: Preparation Of Vehicle For Prednisolone Dispersible Tabletmentioning

confidence: 99%

“…Hausner's ratio. Hausner's ratio of the Prednisolone was determined by the ratio of tapped density and bulk density using the following formula [20].…”

Section: Compressibility Indexmentioning

confidence: 99%

Formulation and evaluation of Prednisolone retention enema as dispersible tablet and vehicle for the treatment of ulcerative colitis

2019

Lett Appl NanoBioSci

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Ulcerative colitis is a chronic idiopathic inflammatory bowel disease that causes chronic inflammation and damage in the gastrointestinal (GI) tract that typically presents in the second or third decade of life with bloody diarrhoea and abdominal cramps. The objective of the present work was to formulate and evaluate of Prednisolone retention enema as a dispersible tablet and it is suspended in suitable vehicle for the treatment of ulcerative colitis. In the present work, an attempt has been made to formulate and evaluate Prednisolone retention enema as a dispersible tablet by using three different methods (direct compression (F1 to F3, wet granulation (F4 and F5) and slugging method (F6)). Prepared dispersible tablets were administered with the help of vehicle for the effective treatment of ulcerative colitis. Dispersible tablets were evaluated for various parameters. In vitro drug release and microbiological evaluation studies were performed to the best formulation in rectal suspension. Then the best formulation was subjected to carry out for stability studies at three different temperatures. Among the six formulations, F6 formulation showed better results. FT-IR study showed that there was no interaction between a drug and excipients. In vitro drug release and microbiological evaluation studies were performed for F6 formulation in rectal suspension. About 99.06 % of the drug was released at 60 min. and also it was found to be microbiologically stable. Results from the stability studies showed that F6 formulation alone and with rectal suspension was stable for a period of 90 days. It was concluded that F6 formulation in rectal suspension possesses a promising future for the treatment of ulcerative colitis.

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Particle, Powder, and Compact Characterization

Cited by 45 publications

References 62 publications

Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates

Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

Formulation and evaluation of Prednisolone retention enema as dispersible tablet and vehicle for the treatment of ulcerative colitis

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