Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure

Teis, Albert; Cediel, Germán; Amigó, Núria; Julve, Josep; Aranyo, J; Andres-Cordon, JF; Puig-Jové, Carlos; Castelblanco, Esmeralda; Gual-Capllonch, Francisco; Ferrer-Sistach, Elena; Vallejo, Nuria Garatachea; Juncà, Gladys; López-Ayerbe, Jorge; Antonio, Marta de; Domingo, Mar; Santiago‐Vacas, Evelyn; Codina, Pau; Mauricio, Dı́dac; Lupón, Josep; Alonso, Núria; Bayés‐Genís, Antoni

doi:10.1038/s41598-021-82861-6

Cited by 25 publications

(16 citation statements)

References 40 publications

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“…Four blood lipids—TC, TG, LDL‐C, and HDL‐C—are important indicators used to reveal changes in blood lipids (Chen et al, 2021 ). Earlier studies showed that HDL‐C levels negatively correlate with carotid atherosclerosis progression (Hedayatnia et al, 2020 ; Teis et al, 2021 ), while higher LDL‐C levels and lower HDL‐C levels might correlate with cardiovascular diseases (CVDs) such as stroke (Zhang, Wei, et al, 2020 ). This LDL‐C/HDL‐C ratio was proved to be more valuable than any single lipid component—especially LDL‐C—to predict CVDs risk (Hedayatnia et al, 2020 ; Zhang, Wei, et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Capsaicin combined with dietary fiber prevents high‐fat diet associated aberrant lipid metabolism by improving the structure of intestinal flora

Gong

Zhou

Zhang

et al. 2022

Food Science & Nutrition

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During the 21st century, China has been experiencing an era of rapid nutritional transformation. The traditional Chinese diet, rich in carbohydrates and vegetable fibers, has been increasingly replaced by refined foods and a more Western-style diet (Tian & Wang, 2019). These steadily spreading eating habits, entailing the consumption of refined saturated fat-rich foods as contrasted with vegetable fibers are promoting obesity and metabolic syndromes/ diseases (dyslipidemias, insulin resistance, diabetes), steatohepatitis, and cardiovascular illnesses (Hosoi et al., 2016;Lindroos et al., 2021).Typically, microbes in the cecum and colon portions of the gut metabolize vegetable fibers into acetic, propionic, and butyric acids, altogether indicated as short-chain fatty acids (SCFAs) (Barber et al., 2020;Cheng et al., 2020). In their turn, SCFAs interact with enteroendocrine L cell receptors whose activation induces the tyrosine-tyrosine (PYY) peptide release (Farzi et al., 2021).

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Section: Discussionmentioning

confidence: 99%

Capsaicin combined with dietary fiber prevents high‐fat diet associated aberrant lipid metabolism by improving the structure of intestinal flora

Gong

Zhou

Zhang

et al. 2022

Food Science & Nutrition

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“…Several methods are available for HDL separation, which are used with varying frequency in studies (gel electrophoresis 49 , nuclear magnetic resonance 50 , and ion mobility 51 ). They are based on different physicochemical characteristics of the HDL molecules and separate the particles according to size, charge, density, etc.…”

Section: Discussionmentioning

confidence: 99%

The profile of HDL-C subfractions and their association with cardiovascular risk in the Hungarian general and Roma populations

Pikó

Kósa

Sándor

et al. 2022

Sci Rep

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High-density lipoprotein cholesterol (HDL-C) is not a homogenous lipid fraction, but it can be further divided into subfractions. It is well-known that the Roma population has a high prevalence of reduced HDL-C levels and cardiovascular diseases (CVDs). However, it is unknown how this reduction affects different HDL subfractions, and whether changes in their quantity/representation are associated with an increased cardiovascular risk among them. In the present study, the HDL subfraction profile of the Hungarian general (HG) and the Roma populations were compared, and the subfractions showing a significant difference between the two populations were identified. The association of HDL subfractions with CVD risk estimated by the Framingham risk score (FRS) and the Systematic COronary Risk Evaluation (SCORE) algorithms were also defined. The present study is the first to find a significant association between HDL subfractions and cardiovascular risk estimated by FRS and SCORE. Ten HDL subfractions were investigated on small but carefully selected samples comprising 100 control subjects (with normal lipid profile) and 277 case subjects (with reduced HDL-C levels) from HG and Roma populations of a complex health survey. The level of HDL-1 to 3 subfractions and HDL-L showed a significant inverse association with cardiovascular risk estimated by both SCORE and FRS algorithms, whereas HDL-4 to 6 and HDL-I only for FRS. A higher representation (in %) of HDL-1 to 3 has a significant risk-reducing effect, while HDL-8 to 10 has a risk-increasing effect estimated by FRS. Our results confirmed that reduced levels of HDL-6 and -7 expressed in mmol/L were significantly associated with Roma ethnicity.

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“…A recent study reported a positive association between HDL particle size, as well as HDL cholesterol content (calculated as HDL-C/HDL-p ratio), and cardiovascular death in CHF patients [ 44 ]. In the present study, univariable Cox regression analysis revealed a significant positive association of the HDL-C/HDL-apoA-II ratio (HR 1.37 per 1 SD increase, 95% CI 1.15–1.62, p < 0.001), but not the HDL-C/apoA-I ratio (HR 1.16 per 1 SD increase, 95% CI 0.96–1.41, p = 0.134), with 1-year mortality.…”

Section: Discussionmentioning

confidence: 99%

HDL-apoA-II Is Strongly Associated with 1-Year Mortality in Acute Heart Failure Patients

et al. 2022

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The prognostic value of the subset of high-density lipoprotein (HDL) particles containing apolipoprotein (apo)A-II (HDL-apoA-II) in acute heart failure (AHF) remains unexplored. In this study, baseline serum levels of HDL-apoA-II (total and subfractions 1–4) were measured in 315 AHF patients using NMR spectroscopy. The mean patient age was 74.2 ± 10.5 years, 136 (43.2%) were female, 288 (91.4%) had a history of cardiomyopathy, 298 (94.6%) presented as New York Heart Association class 4, and 118 (37.5%) patients died within 1 year after hospitalization for AHF. Multivariable Cox regression analyses, adjusted for age and sex as well as other clinical and laboratory parameters associated with 1-year mortality in the univariable analyses, revealed a significant inverse association of HDL-apoA-II (hazard ratio (HR) 0.67 per 1 standard deviation (1 SD) increase, 95% confidence interval (CI) 0.47–0.94, p = 0.020), HDL2-apoA-II (HR 0.72 per 1 SD increase, 95% CI 0.54–0.95, p = 0.019), and HDL3-apoA-II (HR 0.59 per 1 SD increase, 95% CI 0.43–0.80, p < 0.001) with 1-year mortality. We conclude that low baseline HDL-apoA-II, HDL2-apoA-II, and HDL3-apoA-II serum levels are associated with increased 1-year mortality in AHF patients and may thus be of prognostic value in AHF.

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Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure

Cited by 25 publications

References 40 publications

Capsaicin combined with dietary fiber prevents high‐fat diet associated aberrant lipid metabolism by improving the structure of intestinal flora

Capsaicin combined with dietary fiber prevents high‐fat diet associated aberrant lipid metabolism by improving the structure of intestinal flora

The profile of HDL-C subfractions and their association with cardiovascular risk in the Hungarian general and Roma populations

HDL-apoA-II Is Strongly Associated with 1-Year Mortality in Acute Heart Failure Patients

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