Particle synthesis by rapid expansion of supercritical solutions (RESS): Current state, further perspectives and needs

Türk, Michael

doi:10.1016/j.jaerosci.2021.105950

Cited by 16 publications

(12 citation statements)

References 193 publications

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“…The RESS technique is carried out in two steps: initially, a solution containing lipids is dissolved in ethanol (5–10% of v / v ) and supercritical CO 2 within an extractor. The resulting solution is depressurized through a heated nozzle in a low-pressure chamber [ 115 , 116 , 117 ]. The rapid expansion/decompression (at supersonic speeds) through a nozzle favors the decrease of the pressure and the evaporation of CO 2 , thus leading to the supersaturation, and then, to the precipitation of the solid (that will be collected from the gaseous stream).…”

Section: Novel Technologies For Liposome Preparationmentioning

confidence: 99%

“…The size (size distribution) and encapsulation efficiency (EE) of the liposomes can be regulated by modifying the pre-expansion pressure, the flow rate, and the nozzle position in the low-pressure chamber (reactor). The main drawbacks of this approach are connected with the poor solubility of most of the biomaterials (e.g., polymer-based macromolecules) in SC-CO 2 , and the difficulty of the separation between co-solvents and vesicles during the depressurization process, which causes a sensitive increase of the liposome production costs [ 115 , 116 , 117 ].…”

Section: Novel Technologies For Liposome Preparationmentioning

confidence: 99%

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Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

2022

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Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease of preparation, as well as their large variety of structural properties, liposomes have been employed in a large variety of nanomedicine and biomedical applications, including nanocarriers for drug delivery, in nutraceutical fields, for immunoassays, clinical diagnostics, tissue engineering, and theranostics formulations. Particularly important is the role of liposomes in drug-delivery applications, as they improve the performance of the encapsulated drugs, reducing side effects and toxicity by enhancing its in vitro- and in vivo-controlled delivery and activity. These applications stimulated a great effort for the scale-up of the formation processes in view of suitable industrial development. Despite the improvements of conventional approaches and the development of novel routes of liposome preparation, their intrinsic sensitivity to mechanical and chemical actions is responsible for some critical issues connected with a limited colloidal stability and reduced entrapment efficiency of cargo molecules. This article analyzes the main features of the formation and fabrication techniques of liposome nanocarriers, with a special focus on the structure, parameters, and the critical factors that influence the development of a suitable and stable formulation. Recent developments and new methods for liposome preparation are also discussed, with the objective of updating the reader and providing future directions for research and development.

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Section: Novel Technologies For Liposome Preparationmentioning

confidence: 99%

Section: Novel Technologies For Liposome Preparationmentioning

confidence: 99%

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

2022

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“…Gholamhossein Sodeifian 1,2,3* , Chieh-Ming Hsieh 4 , Amirmuhammad Tabibzadeh 1,2,3 , Hsu-Chen Wang 4 & Maryam Arbab Nooshabadi 5 Palbociclib is a poorly water-soluble medicine which acts against metastatic breast cancer cells. Among various techniques to improve the solubility of this medicine, applying supercritical technologies to produce micro-and nano-sized particles is a possible option.…”

Section: Solubility Of Palbociclib In Supercritical Carbon Dioxide Fr...mentioning

confidence: 99%

“…3 Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, Kashan 87317-53153, Iran. 4 Department of Chemical and Materials Engineering, National Central University, Taoyuan 320317, Taiwan. 5 Bolvar Ghotbe Ravandi, Islamic Azad University of Kashan, Ostaadan Street, Kashan 87159-98151, Iran.…”

Section: Solubility Of Palbociclib In Supercritical Carbon Dioxide Fr...mentioning

confidence: 99%

“…In this regard, particle size manipulation can be helpful in meeting the challenge. For this purpose, the generation of new solubility data on palbociclib, especially in supercritical carbon dioxide (ScCO 2 ), can clear the way for micro and nanoparticle production via relevant processes such as rapid expansion of supercritical solution (RESS) 4 and supercritical anti-solvent precipitation (SAS) 5 . The latter is based on fast injection of liquid solution of organic/inorganic solvent and solid solute into the supercritical fluid (SCF), while the former is carried out by depressurization the mixture of supercritical fluid and solid solute through a heated nozzle at high speed.…”

Section: Introductionmentioning

confidence: 99%

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Solubility of palbociclib in supercritical carbon dioxide from experimental measurement and Peng–Robinson equation of state

Sodeifian

Hsieh

Tabibzadeh

et al. 2023

Sci Rep

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Palbociclib is a poorly water-soluble medicine which acts against metastatic breast cancer cells. Among various techniques to improve the solubility of this medicine, applying supercritical technologies to produce micro- and nano-sized particles is a possible option. For this purpose, extraction of solubility data is required. In this research, the solubility of palbociclib in supercritical carbon dioxide (ScCO2) at different equilibrium conditions was measured at temperatures between 308 and 338 K and pressures within 12–27 MPa, for the first time. The minimum and maximum solubility data were found to be 8.1 × 10–7 (at 338 K and 12 MPa) and 2.03 × 10–5 (at 338 K and 27 MPa), respectively. Thereafter, two sets of models, including ten semi-empirical equations and three Peng–Robinson (PR) based integrated models were used to correlate the experimental solubility data. Bian’s model and PR equation of state using van der Waals mixing rules (PR + vdW) showed better accuracy among the examined semi-empirical and integrated models, respectively. Furthermore, the self-consistency of the obtained data was confirmed using two distinct semi-empirical models. At last, the total and vaporization enthalpies of palbociclib solubility in ScCO2 were calculated from correlation results of semi-empirical equations and estimated to be 40.41 and 52.67 kJ/mol, respectively.

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Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

Askarizadeh,

Esfandiari,

Honarvar

et al. 2023

ChemBioEng Reviews

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Proper medication dissolution must be ensured when developing or manufacturing a new solid dosage form. Quantitative analyses performed in dissolution or release tests become simpler when applying mathematical formulae which represent dissolution outcomes as a function of several dosage form properties. Methodologies utilized to examine the kinetics of drug release from controlled‐release formulations are reviewed. The analysis of variance was conducted using statistical, model‐independent, and ‐dependent techniques for the dissolution profile comparison and fitting, respectively. Model equations, including zero‐ and first‐order, Hixson‐Crowell, Weibull, Higuchi, Korsmeyer‐Peppas, Baker‐Lonsdale, Hopfenberg, etc., were employed to match the experimental data. Additional release parameters were taken to illustrate the drug release patterns. Using correlation factors and the Akaike information criterion (AIC), the best‐fitting model was discovered, as were the transport phenomena affecting the behavior of the recognized formulations.

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Particle synthesis by rapid expansion of supercritical solutions (RESS): Current state, further perspectives and needs

Cited by 16 publications

References 193 publications

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application

Solubility of palbociclib in supercritical carbon dioxide from experimental measurement and Peng–Robinson equation of state

Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

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