Parvovirus B19 in pregnancy

Dijkmans, Anneke C.; Jong, Eveline P. de; Dijkmans, Ben A. C.; Lopriore, Enrico; Vossen, Ann C.T.M.; Walther, Frans J.; Oepkes, Dick

doi:10.1097/gco.0b013e3283505a9d

Cited by 62 publications

(16 citation statements)

References 49 publications

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“…B19V exposure in early pregnancy may increase the rate of spontaneous abortion. Fetal demise was recognized early and has been extensively reviewed (488)(489)(490)(491)(492)(493)(494)(495)(496)(497)(498). From seroepidemiology, an annual loss of 120 fetuses was calculated for Japan (499), and about twice this number might be extrapolated for the United States.…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…This leads to the obvious suggestion that IUT should preferably be done before hydrops develops. In the absence of screening programs for parvovirus susceptibility or infection in pregnant women, the majority is still referred only after the detection of hydrops [26,27,28,29]. …”

Section: Indications For Iutmentioning

confidence: 99%

Intrauterine Blood Transfusion: Current Indications and Associated Risks

Lindenburg

Kamp

Oepkes³

2014

Fetal Diagn Ther

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143

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Fetal anemia is a serious complication in pregnancy and associated with perinatal mortality and morbidity. During 25 years of worldwide experience with intravascular intrauterine blood transfusion, a variety of indications have been described. Intrauterine transfusion (IUT) treatment is considered most successful for fetal anemia due to red cell alloimmunization. Moreover, the use of this procedure has also been reported in pregnancies with parvovirus B19 infection, fetomaternal hemorrhage and placental chorioangiomas, for example. This review focuses on the current indications of intrauterine blood transfusions. In addition, we describe the potential complications of IUT treatment.

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“…Maternally administrated IVIG therapy during pregnancy for improving maternal and fetal outcome in severe B19 virus-induced disorders has also been reported in two cases without obvious complications [ 8 , 9 ]. Weekly fetal ultrasound examination including estimation of middle cerebral artery peak systolic velocity (MCA-PSV) for timely detection of possible fetal anemia and hydrops fetalis during a post-exposure period of 12 to 20 weeks was highly recommended [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 infection presenting with severe erythroid aplastic crisis during pregnancy in a woman with autoimmune hemolytic anemia and alpha-thalassemia trait: a case report

Chen

Wang

et al. 2015

J Med Case Reports

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IntroductionParvovirus B19 virus commonly causes subclinical infection, but it can prove fatal to the fetus during pregnancy and cause severe anemia in an adult with hemolytic diseases. We present the case of a woman with autoimmune hemolytic anemia who was diagnosed with parvovirus B19-induced transient aplastic crisis during her second trimester of pregnancy and faced the high risk of both fetal and maternal complications related to this specific viral infection. To the best of our knowledge, the experience of successful intravenous immunoglobulin treatment for B19 virus infection during pregnancy, as in our case, is limited.Case presentationA 28-year-old and 20-week pregnant Chinese woman with genetically confirmed alpha-thalassemia trait was diagnosed with cold antibody autoimmune hemolytic anemia and suffered from transient aplastic crisis caused by B19 virus infection. She received intravenous immunoglobulin treatment to reduce the risk of hydrops fetalis. Her peripheral blood reticulocyte percentage recovered, but anemia persisted, so she underwent several courses of high dose intravenous dexamethasone for controlling her underlying hemolytic problem. Finally, her hemoglobin levels remained stable with no need of erythrocyte transfusion, and a healthy baby boy was naturally delivered.ConclusionsParvovirus B19 virus infection should be considered when a sudden exacerbation of anemia occurs in a patient with hemolytic disease, and the possible fetal complications caused by maternal B19 virus infection during pregnancy should not be ignored. Close monitoring and adequate management can keep both mother and fetus safe.

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Parvovirus B19 in pregnancy

Cited by 62 publications

References 49 publications

Human Parvoviruses

Human Parvoviruses

Intrauterine Blood Transfusion: Current Indications and Associated Risks

Parvovirus B19 infection presenting with severe erythroid aplastic crisis during pregnancy in a woman with autoimmune hemolytic anemia and alpha-thalassemia trait: a case report

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