Parvovirus B19 infection in a patient with common variable immunodeficiency

Zanelli, Magda; Ruggeri, Loredana; Sanguedolce, Francesca; Zizzo, Maurizio; Martino, Giovanni; Genua, Angelo; Ascani, Stefano

doi:10.4084/mjhid.2021.026

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…In immunocompetent people, it typically causes erythema infectiosum in children (aka “slapped cheek syndrome”) and, in adults, can cause an acute symmetric polyarthropathy [ 234 ]. In immunocompromised hosts, persistent infection may lead to pure red cell aplasia and chronic anaemia [ 235 ]. There are two reported cases of patients with CVID presenting with erythroid aplasia secondary to HPV-B19 with resolution following IgRT [ 235 , 236 ].…”

Section: Other Virusesmentioning

confidence: 99%

“…In immunocompromised hosts, persistent infection may lead to pure red cell aplasia and chronic anaemia [ 235 ]. There are two reported cases of patients with CVID presenting with erythroid aplasia secondary to HPV-B19 with resolution following IgRT [ 235 , 236 ]. There was a case of 48 year old male with CVID, presenting with a chronic monoarthritis of the wrist found to have parvoviral B19 DNA in synovial tissues which resolved after initiation of IgRT [ 237 ].…”

Section: Other Virusesmentioning

confidence: 99%

“…The introduction of IgRT resolved the viraemia and constitutional symptoms over 15 months, though the arthritis persisted [ 238 ]. Regarding diagnosis of the virus in CVID, HPV-B19 serology can be negative due to dysregulated antibody production and HPV-B19 PCR analysis may be necessary for diagnosis [ 235 ]. In all these cases, the initiation of IgRT was sufficient to clear the virus, indicating the importance of considering HPV-B19 infection and immunodeficiency in those presenting with reticulocytopaenic anaemia, and the role of immunoglobulin in treating the syndrome.…”

Section: Other Virusesmentioning

confidence: 99%

See 2 more Smart Citations

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review

Al-Hakim,

Kacar,

Savic

2024

JCM

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Common Variable Immunodeficiency (CVID) is a heterogeneous primary immunodeficiency disorder characterised by impaired antibody production, leading to recurrent infections and an increased susceptibility to viral pathogens. This literature review aims to provide a comprehensive overview of CVID’s relationship with viral infections, encompassing disease pathogenesis, key presenting features, specific monogenic susceptibilities, the impact of COVID-19, and existing treatment options. The pathogenesis of CVID involves complex immunological dysregulation, including defects in B cell development, antibody class switching, and plasma cell differentiation. These abnormalities contribute to an impaired humoral immune response against viral agents, predisposing individuals with CVID to a broad range of viral infections. Genetic factors play a prominent role in CVID, and monogenic drivers of CVID-like disease are increasingly identified through advanced genomic studies. Some monogenic causes of the CVID-like phenotype appear to cause specific viral susceptibilities, and these are explored in the review. The emergence of the COVID-19 pandemic highlighted CVID patients’ heightened predisposition to severe outcomes with viral infections. This review explores the clinical manifestations, outcomes, and potential therapeutic approaches for COVID-19 in CVID patients. It assesses the efficacy of prophylactic measures for COVID-19, including vaccination and immunoglobulin replacement therapy, as well as trialled therapies.

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Section: Other Virusesmentioning

confidence: 99%

Section: Other Virusesmentioning

confidence: 99%

Section: Other Virusesmentioning

confidence: 99%

See 1 more Smart Citation

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review

Al-Hakim,

Kacar,

Savic

2024

JCM

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“…Given that antibody is felt to mediate clearance, it is to be expected that lymphoid disorders, as opposed to innate defects, would be the entities primarily associated with prolonged anemia or aplastic crisis. Case reports of patients having clinically significant infections with Nezelof syndrome, a T‐cell disorder without a specific genetic etiology, common variable immunodeficiency, hyper IgM syndrome, and agammaglobulinema represent examples of lymphoid disorders 178–181 . These reports demonstrate the importance of adaptive control of parvovirus B19, nevertheless, given the high prevalence in communities, it is surprising that significant anemia is not reported more often in these vulnerable populations (Table 1).…”

Section: Viruses Causing a Distinct Phenotype In Patients With Ieimentioning

confidence: 99%

Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity

Kilich,

Perelygina,

Sullivan

2023

Immunological Reviews

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SummaryInfectious susceptibility is a component of many inborn errors of immunity. Nevertheless, antibiotic use is often used as a surrogate in history taking for infectious susceptibility, thereby disadvantaging patients who present with viral infections as their phenotype. Further complicating clinical evaluations are unusual manifestations of viral infections which may be less familiar that the typical respiratory viral infections. This review covers several unusual viral phenotypes arising in patients with inborn errors of immunity and other settings of immune compromise. In some cases, chronic infections lead to oncogenesis or tumor‐like growths and the conditions and mechanisms of viral‐induced oncogenesis will be described. This review covers enterovirus, rubella, measles, papillomavirus, and parvovirus B19. It does not cover EBV and hemophagocytic lymphohistiocytosis nor lymphomagenesis related to EBV. EBV susceptibility has been recently reviewed. Our goal is to increase awareness of the unusual manifestations of viral infections in patients with IEI and to describe treatment modalities utilized in this setting. Coincidentally, each of the discussed viral infections can have a cutaneous component and figures will serve as a reminder of the physical features of these viruses. Given the high morbidity and mortality, early recognition can only improve outcomes.

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Parvovirus B19 induced acute severe anaemia in a well-controlled HIV-positive individual

Swaine,

Ahmad,

Abbara

et al. 2024

Clinical Infection in Practice

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Parvovirus B19 infection in a patient with common variable immunodeficiency

Abstract: n/a

Cited by 4 publications

References 7 publications

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review

The Scope and Impact of Viral Infections in Common Variable Immunodeficiency (CVID) and CVID-like Disorders: A Literature Review

Rubella virus chronic inflammatory disease and other unusual viral phenotypes in inborn errors of immunity

Parvovirus B19 induced acute severe anaemia in a well-controlled HIV-positive individual

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