Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi

Pekmezci, Didem; Colak, Zeynep Nurselin

doi:10.35229/jaes.993377

Cited by 3 publications

(8 citation statements)

References 49 publications

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“…We found 7.6 as the cutoff value for NEU/LYM for the CDV infected dogs for distinguish them from healthy ones, similarly Hodgson et al (2018). Contrary to other studies (Çakir & Pekmezci 2019;Benvenuti et al, 2020;Pekmezci & Çolak, 2021), our NEU/LYM ratio was found to be high in the control dogs.…”

Section: Discussioncontrasting

confidence: 78%

“…Meanwhile we found the mean MONO/LYM ratios of the infected dogs with B. burgdorferi and control group 0.7 and 0.4, respectively. Although a similar situation was observed in another of previously study, the mean MONO/LYM ratio in the PVI and control group was found to be 1.2, and 0.4, respectively (Pekmezci & Çolak, 2021). Contrary to previously reports (Çakir & Pekmezci 2019;Pekmezci & Çolak, 2021) we found a median MONO/LYM level as 2.33 in the CDV infected dogs.…”

Section: Discussionsupporting

confidence: 75%

“…In humans, NEU/LYM, MONO/LYM and PLT/LYM ratios that can be calculated using WBC and is easily accessible accepted as an independent predictive index of morbidity and mortality in sepsis and the results have consistently shown that higher NEU/LYM, MONO/LYM and PLT/LYM ratios are independent diagnostic and prognostic markers (Zahorec, 2021). Today these ratios are also have been started to be studying in various disease of the dog and cat (Burton et al, 2013;Rejec et al, 2017;Troìa et al, 2017;Hodgson et al, 2018;Çakir & Pekmezci 2019;Benvenuti et al, 2020;Pierini et al, 2020;Becher et al, 2021;Conway et al, 2021;Gori et al, 2021;Neumann, 2021;Pekmezci & Çolak, 2021;Park et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Pekmezci & Çakır (2019) found NEU/LYM ratio as 7.2 of the dogs infected with Borrelia burgdorferi and 5.2 in the healthy group dogs. In another study, in which dogs naturally infected with Parvovirus (PVI) and healthy controls were compared, the researchers found the mean NEU/LYM ratio as 4.3 in the PVI group (Pekmezci & Çolak, 2021). Hodgson et al (2018) found the mean NEU/LYM as 25.1 in dogs with sepsis and 3.9 in healthy dog population.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, NEU/LYM, MONO/LYM and PLT/LYM ratios as bedside parameters, which are frequently used in cardiovascular diseases (Li et al, 2017), malignancies (Xiang et al, 2017, acute pancreatitis (Wang et al, 2017), autoimmune diseases (Chandrashekara et al, 2017) and chronic obstructive pulmonary disease (Yao et al, 2017) in human medicine, can be used as markers of poor prognosis or major inflammation in dogs with CDV infections in dogs. Nowadays researches on NEU/LYM, MONO/LYM and PLT/LYM in veterinary medicine, have been increasing (Burton et al, 2013;Rejec et al, 2017;Troìa et al, 2017;Hodgson et al, 2018;Çakir & Pekmezci 2019;Benvenuti et al, 2020;Pierini et al, 2020;Becher et al, 2021;Conway et al, 2021;Gori et al, 2021;Neumann, 2021;Pekmezci & Çolak, 2021). Therefore, the main purpose of this study is to investigate whether these easy and cost-effective values can contribute to the clinician's diagnosis of CDV infection after comparing the NEU/LYM, MONO/LYM and PLT/LYM values in dogs with naturally CDV Ag positive and clinical symptoms with healthy dogs.…”

Section: Introductionmentioning

confidence: 99%

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A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Pekmezci

KONAÇOĞLU

Colak

2022

Journal of Anatolian Environmental and Animal Sciences

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It is aimed to compare the pretreatment Neutrophil/Lymphocyte (NEU/LYM), Monocyte/Lymphocyte (MONO/LYM), and Platelet/Lymphocyte (PLT/LYM) ratios with whole blood count (WBC) of dogs naturally infected Canine Distemper Virus (CDV) with healthy individuals within this preliminary study. For this purpose, retrospectively, 22 owned, 3-12 (6.2) months old dogs diagnosed with CDV infection found to be positive with rapid test kits based up on the records of Animal Hospital, Faculty of Veterinary Medicine, constituted the study group. On the other hand, eight owned, 2-10 (8.2) months old, and healthy dogs enrolled in the control group. In the comparison of pre-treatment NEU/LYM, MONO/LYM, PLT/LYM, and WBC parameters between the groups, we found only a statistical difference (P 0.05) between median LYM, EOS, NEU%, LYM%, EOS%, BAS%, MCH, MCHC, RDWCV, PLT with NEU/LYM, MONO/LYM, PLT/LYM ratios. The median NEU/LYM, MONO/LYM, and PLT/LYM levels in the CDV positive group were 31.9, 2.33, and 391.2, respectively, while the same values of the control group were determined as 6.39, 0.37 and 187.7, respectively. The optimized cut-off points of NEU/LYM, MONO/LYM, and PLT/LYM values in estimating CDV patients were also determined as NEU/LYM =7.6, MONO/LYM=0.61 and PLT/LYM=0.852, respectively. In conclusion, this preliminary study suggests that NEU/LYM, MONO/LYM, and PLT/LYM values may be inexpensive, objective, and non-invasive new marker candidates for clinicians to support the diagnosis of CDV infected dogs in suspicious circumstances.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Pekmezci

KONAÇOĞLU

Colak

2022

Journal of Anatolian Environmental and Animal Sciences

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Diarrhea in Cats Infected with Cystoisospora spp. - Evaluation of the Neutrophil-to-Lymphocyte Ratio and Monocyte-to-Lymphocyte Ratio

Tuna,

Kirkulak

2023

Acta Scientiae Vet.

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Background: Cystoisospora spp. is considered a potential pathogen to cause diarrhoea in cats, and the disease occurs clinically, especially in young, weak and immunocompromised cats. The present study aimed to evaluate the clinical utility and diagnostic roles of neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte (MLR) ratios in diarrheal cats infected with Cystoisospora spp. Materials, Methods & Results: Twenty-five cats with diarrhea due to infection caused by Cystoisospora spp. and 15 healthy cats were included in this study. The anamnesis, clinical and laboratory findings of all cats were recorded. A clinical severity score was generated for diarrheal cats, which included activity, appetite, presence of vomit, and faecal consistency. Also, cats infected with Cystoisospora spp. were classified as systemic inflammatory response syndrome (SIRS) positive (+) and SIRS (-) group according to the presence of at least 3 of the SIRS criteria. The Cystoisospora spp. oocysts were diagnosed by direct smear and simple faecal flotation. Cats found positive for other parasitic and protozoal agents by faeces examination were excluded from the study. Complete blood counts (CBC) were performed with an automated blood cell counter for all cats. Blood smears were prepared (with May-Grunwald Giemsa) from samples, and the CBC results were confirmed microscopically (objective100x). White blood cell (WBC), neutrophil, lymphocyte and monocyte counts were recorded directly from the CBC. The neutrophil-to-lymphocyte ratio was calculated as the ratio of the absolute neutrophil count to the absolute lymphocyte count. The monocyte-to-lymphocyte was calculated as the absolute monocyte count ratio to the absolute lymphocyte count. White blood cell (P = 0.015), neutrophil (P = 0.001), monocyte (P = 0.033), NLR (P = 0.000) and MLR (P = 0.042) of diarrheal cats infected with Cystoisospora spp. were significantly higher than in the healthy group. There was no significant difference between groups in the lymphocyte counts (P > 0.05). SIRS (+) group had statistically significantly higher WBC (P = 0.014), neutrophil counts (P = 0.000), NLR (P = 0.000) and MLR (P = 0.037) than the healthy group. Also, neutrophil counts and NLR of the SIRS (+) group were statistically significantly higher than the SIRS (-) group (P = 0.032; P = 0.001, respectively). However, there was no significant difference SIRS (+), SIRS (-), and healthy groups regarding lymphocyte and monocyte counts (P > 0.05). The clinical severity of the disease positively correlated with NLR and MLR. Also, the best cut-off value of NLR to predict SIRS was > 1.67, with 92.86 % sensitivity and 84.62 % specificity. MLR was not a useful predictor for SIRS. Discussion: NLR and MLR are parameters derived from complete blood count. In recent years, they have been used in human and veterinary medicine as a biomarker in the diagnosis, prognosis and treatment follow-up of various diseases and provide valuable information about inflammation. In cats, there are limited studies on NLR, and to our knowledge, there are no studies on MLR. The current study suggests that NLR and MLR may be used to determine the severity of the inflammatory condition in diarrheal cats infected with Cystoisospora spp., and NLR is a useful marker for predicting SIRS status in these cats. In addition, this study also will contribute to larger-scale studies in the future. Keywords: cats, complete blood count, Cystoisospora, diarrhoea, NLR, MLR, SIRS.

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Parvovi̇ral Enteri̇tli̇ Köpekleri̇n Bi̇yoki̇myasal Parametreler Açisindan Değerlendi̇ri̇lmesi̇

Anıl,

Gökgöz

2024

Veteriner Farmakoloji Ve Toksikoloji Derneği Bülteni

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Canine parvovirüs (CPV)enfeksiyonu,1967 yılında keşfedilmesinden itibaren özellikle genç köpeklerin etkilendiği viral kökenli hastalıklardan biridir. Virüsün hızlı bölünen hücrelere affinitesinin bulunması ve dirençli varyantlara dönüşebilme kabiliyetinden dolayı yüksek morbidite ve mortalite ile seyretmektedir. Canine parvovirüs enfeksiyonu ile literatürlerde hastalığın hematolojik bulguları, böbrek-karaciğer enzimleri, akut faz proteinleri, sitokinler, asit-baz bozuklukları, sıvı elektrolit düzeyleri, kan gazları, bağırsak bozukluğu bulguları, lipid profilleri, tiroksin ve kortizol bulguları, koagülasyon profilleri ve kalp biyomarkırları tasvir edilmiştir. Bu derleme makalesinin amacı parvovirüs ile enfekte olan köpeklerin biyokimyasal parametreler açısından incelenip, benzer ve farklı sonuçların, oluşan eksikliklerin ve biyokimyasal yönden yapılabileceklerin sentezi yapılarak, hastalığın tanısına, prognozuna ve tedavisine yardımcı olabilecek bilgilerinin derlenmesidir.

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Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi

Cited by 3 publications

References 49 publications

A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

A Preliminary Study for Determination of Neutrophil to Lymphocyte, Monocyte to Lymphocyte and Platelet to Lymphocyte Ratios in Dogs with Canine Distemper Virus Infection

Diarrhea in Cats Infected with Cystoisospora spp. - Evaluation of the Neutrophil-to-Lymphocyte Ratio and Monocyte-to-Lymphocyte Ratio

Parvovi̇ral Enteri̇tli̇ Köpekleri̇n Bi̇yoki̇myasal Parametreler Açisindan Değerlendi̇ri̇lmesi̇

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