Wireless communications systems have been rapidly growing during the last two decades, and they are gaining a significant role for multiple communication tasks within public transportation buses. In this paper, the impact of topology and morphology of different types of urban buses is analyzed with the aid of an in-house developed 3D ray launching code and compared with onboard measurements of a deployed wireless sensor network (WSN). The presence of human beings has been taken into account, showing a significant influence in the signal attenuation in the case of considering persons. In addition, the statistical analysis of simulation results considering both large-and smallscale fading has been performed, providing good agreement with statistics for typical indoor environments. In addition, a WSN has been programmed and deployed within the buses in order to analyze topological impact with overall system performance, with the aim of minimizing the energy consumption as well as nondesired interference levels. The use of deterministic techniques destined to consider the inherent complexity of the buses can aid in wireless system planning in order to minimize power consumption and increase overall system capacity.Index Terms-Indoor propagation, ray launching, urban buses, wireless sensor network.