Passenger Lymphocyte Syndrome After Simultaneous Pancreas-Kidney Transplantation: A Case Report of an Unusual Cause of Alloimmune Hemolytic Anemia

Hurtarte-Sandoval, A R; Navarro-Cabello, M.D.; Alvarez‐Rivas, Miguel A.; Robles-López, A.I.; Salmeron-Rodriguez, M.D.; Morales, Maria Luisa Agüera; Rodríguez‐Benot, Alberto; Aljama-García, Pedro

doi:10.1016/j.transproceed.2015.08.042

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…We conducted a 10‐year retrospective search in PubMed for English‐language journal articles using key works “passenger lymphocyte syndrome.” The review yielded 63 cases (31 studies) of PLS . Of these, eight cases (four studies) were hematopoietic stem cell and 55 cases (27 studies) were organ transplants . All eight (100%) stem cell transplants and 52 (95%) organ transplants were associated with hemolysis, reflecting a strong bias for identifying or reporting PLS associated with hemolysis.…”

Section: Case Reportmentioning

confidence: 99%

Nonhemolytic passenger lymphocyte syndrome

et al. 2017

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Focusing on hemolysis, without a comparable effort to detect donor-derived antibodies diverts from the primary pathophysiology of PLS and limits capturing the full scope of the syndrome. Recognition of hemolytic and nonhemolytic subcategories of PLS is recommended. When feasible, an antibody screen performed on the donor's plasma when collecting the hematopoietic stem cells or before an organ harvest could result in an alert that the donor has formed an alloantibody(s) and the recipient is a risk for PLS. Alternatively, a routine antibody screen performed on the recipient's plasma 1 week posttransplant and, if negative, repeated 3 to 5 weeks posttransplant would detect any donor-derived antibodies and improve alignment of clinical practice with the pathophysiology of PLS.

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Section: Case Reportmentioning

confidence: 99%

Nonhemolytic passenger lymphocyte syndrome

et al. 2017

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“…Kim et al 11 reported comparable outcomes for ABO NIC and identical liver transplants.Numerous reports have been published documenting hemolysis in NIC liver, kidney and intestine transplants [12][13][14]. However, there are no data on the outcomes of pancreas transplants using NIC donors except for a single case report of passenger lymphocyte syndrome after SPK transplantation 15. Currently, the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN) policy is to only allocate SPK allografts according to certain compatible blood types (Table 2).…”

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confidence: 99%

Pancreas transplantation using compatible but non‐identical ABO blood group donors

Nagaraju

Mangus

Powelson

et al. 2018

Clinical Transplantation

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“…Additionally, there are potentially compatible combinations that involve the donor blood type A2 and instances where incompatible transplants are acceptable [3][4][5][6][7][8][9]. However, there is limited data on the outcomes of pancreas transplants using non identical ABO donors [10]. Current Organ Procurement and Transplantation Network (OPTN) policy restricts certain blood type compatible SPK transplants from occurring (Table 2).…”

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confidence: 99%