Passive-active immunization of man with human tetanus immunoglobulin and adsorbed toxoids of different origin

Cohen, H.; Leussink, A. B.

doi:10.1016/0092-1157(73)90003-6

Cited by 7 publications

(1 citation statement)

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“…The results agree with those obtained by Yamamoto et al (1973) who stated that 6 weeks' interval was beneficial for antitoxin production by DPT vaccine. However, more experiments are needed to confirm this point, since the antitoxin production by the same preparation may differ greatly depending on the reportors (Cohen and Leussink, 1973;Someya et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

STUDIES ON THE ADEQUATE COMPOSITION OF DIPHTHERIA AND TETANUS TOXOIDS^|^mdash;WITH REFERENCE TO THE AMOUNTS OF TOXOIDS AND ALUMINUM ADJUVANT

Someya¹,

Mizuhara

Murata³

et al. 1981

JJMSB

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SUMMARY: Immune response of man to tetanus and diphtheria-tetanus com bined toxoids with different compositions was investigated, with special reference to the long-term immunity. Adsorbed tetanus toxoid with a potency of about 25 IU per human dose endowed a long-lasting immunity sufficient to prevent tetanus to the vaccinees of various age groups, when administered in two doses, followed by a booster injection.Two doses of adsorbed diphtheria-tetanus combined toxoid with potencies of about 20 IU per dose for both components were sufficient to give immunity in infants against diphtheria and tetanus. However, a booster injection should be given within a year to endow a long-lasting immunity.In the case of booster immunization of children with a complete history of im munization against diphtheria and tetanus, a potent long-term immunity was endowed by a single injection of diphtheria-tetanus combined toxoid (plain) with 1 and 3.5 IU per dose, for diphtheria and tetanus components, respectively.

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Section: Discussionmentioning

confidence: 99%