Passive and active middle ear implants

Beutner, Dirk; Hüttenbrink, Karl-Bernd

doi:10.3205/cto000061

Cited by 21 publications

(3 citation statements)

References 157 publications

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“…In the ossicular chain reconstruction, an artificial ossicle (AO) is installed into the middle ear. The prognosis of hearing recovery is affected by AO variations, including the material characteristics ( Jahnke and Plester, 1981 ; Grote et al, 1986 ; Beutner and Hüttenbrink, 2011 ; Shah et al, 2013 ; Jiang et al, 2017 ; Lahlou et al, 2018 ; Siddappa et al, 2019 ); mounting method ( Fleischer, 1991 ); and the shapes of specific geometries, such as the S-shaped prosthesis ( Seivur et al, 2022 ), ball-type structure ( Stoppe et al, 2017 ; Ren et al, 2020 ), C-shaped Shape memory alloys (SMA) prosthesis ( Latalski et al, 2017 ), the partial ossicular replacement prosthesis (PORP), and the total ossicular replacement prosthesis (TORP) ( Kelly et al, 2003 ). It has been found that some of these materials with low biocompatibility tend to be rejected by the body when they are placed in the middle ear.…”

Section: Introductionmentioning

confidence: 99%

Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission

Asakura

Ito

Hirabayashi

et al. 2023

Front. Bioeng. Biotechnol.

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Conductive hearing loss is caused by a variety of defects, such as chronic otitis media, osteosclerosis, and malformation of the ossicles. In such cases, the defective bones of the middle ear are often surgically reconstructed using artificial ossicles to increase the hearing ability. However, in some cases, the surgical procedure does not result in increased hearing, especially in a difficult case, for example, when only the footplate of the stapes remains and all of the other bones are destroyed. Herein, the appropriate shapes of the reconstructed autologous ossicles, which are suitable for various types of middle-ear defects, can be determined by adopting an updating calculation based on a method that combines numerical prediction of the vibroacoustic transmission and optimization. In this study, the vibroacoustic transmission characteristics were calculated for bone models of the human middle ear by using the finite element method (FEM), after which Bayesian optimization (BO) was applied. The effect of the shape of artificial autologous ossicles on the acoustic transmission characteristics of the middle ear was investigated with the combined FEM and BO method. The results suggested that the volume of the artificial autologous ossicles especially has a great influence on the numerically obtained hearing levels.

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Section: Introductionmentioning

confidence: 99%

Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission

Asakura

Ito

Hirabayashi

et al. 2023

Front. Bioeng. Biotechnol.

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“…In recent years, alloplastic prostheses have been designed with synthetic materials, such as metals, ceramics, plastics, and composites [1,8]. These prostheses are classified as Partial Ossicular Replacement Prostheses (PORP) when mounted upon the intact stapes, and Total Ossicular Replacement Prostheses (TORP) for cases with no stapes superstructure [9,10]. Currently, the most satisfactory alloplastic material in terms of hearing, lightness, rigidity, biocompatibility results, and easy surgical manipulation is titanium, used in ossicular reconstruction since the early 1990s [4,11,12].…”

Section: Introductionmentioning

confidence: 99%

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Mosconi,

Carlotto,

Caliogna

et al. 2023

JFB

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Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossicular middle ear replacement prostheses, to overcome extrusion while preserving acoustic properties. This in vitro study aims to explore, for the first time in current literature, the feasibility of a biohybrid middle ear prosthesis, composed of titanium surrounded by a bone extracellular matrix as bio-coating. We have hereby studied the adhesion and proliferation of human adipose-derived mesenchymal stem cells (hASC) on titanium scaffolds in vitro. Moreover, we identified the osteogenic differentiation of hASC using an immunofluorescence assay to analyze osteoblasts’ gene expression profiles (Alp, Runx2, Col1a1, Osx, and Bglap), and we counted the presence of collagen as a marker of hASC’s ability to secrete an extracellular matrix. We utilized scanning electron microscopy to evaluate the presence of an extracellular matrix on the scaffolds. Our preliminary data demonstrated the titanium’s ability to support human adipose-derived mesenchymal stem cell colonization, proliferation, and osteoblastic differentiation, in order to obtain a biohybrid device. Our experience seems encouraging; thus, we advocate for further in vivo research to corroborate our results regarding bone transplantation.

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“…The application of bioceramics has proven to be effective in numerous biomedical areas, including tissue engineering [ 10 ], ophthalmology [ 11 ], otolaryngology [ 12 ], cardiology [ 13 , 14 , 15 ], orthopedics [ 16 ], dentistry [ 17 ], etc. In orthopedics, bioceramics are used to coat metallic implants [ 14 ]; as bone cement in arthroplasty, vertebroplasty, and kyphoplasty surgeries [ 18 ]; bone grafts, bone fillers [ 7 ]; and so on.…”

Section: Introductionmentioning

confidence: 99%

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

et al. 2022

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Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or after medical procedures. The radiopacifiers are frequently heavy elements of the periodic table, such as Bi, Zr, Sr, Ba, Ta, Zn, Y, etc., or their relevant compounds that can confer enhanced radiopacity. Radiopaque bioceramics are also intriguing additives for biopolymers and hybrids, which are extensively researched and developed nowadays for various biomedical setups. The present work aims to provide an overview of radiopaque bioceramics, specifically crystalline, non-crystalline (glassy), and nanostructured bioceramics designed for applications in orthopedics, dentistry, and cancer therapy. Furthermore, the modification of the chemical, physical, and biological properties of parent ceramics/biopolymers due to the addition of radiopacifiers is critically discussed. We also point out future research lacunas in this exciting field that bioceramists can explore further.

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Passive and active middle ear implants

Cited by 21 publications

References 157 publications

Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission

Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Radiopaque Crystalline, Non-Crystalline and Nanostructured Bioceramics

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