Past, present, and future research in the field of composite tissue allotransplantation

Kann, Brian R.; Furnas, David W.; Hewitt, Charles W.

doi:10.1002/1098-2752(2000)20:8<393::aid-micr9>3.0.co;2-o

Cited by 18 publications

(10 citation statements)

References 63 publications

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“…Then in the 16th century in Bologna, Italy, Gaspare Tagliacozzi, who many regard as the "father of plastic surgery", reportedly used a flap of tissue transplanted from a slave to reconstruct the severed nose of a man. The story goes that the reconstructed nose survived for 3 years, until its donor died, at which time it rejected [3,4].…”

Section: Introductionmentioning

confidence: 99%

Composite Tissue Allotransplantation (CTA): Current Status and Future Insights

et al. 2001

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Approximately 7 million individuals (over 1 million amputees) require complex reconstructive procedures in the United States each year. The recent success of clinical composite tissue allotransplantation, attests to the fact that composite tissue allografts have tremendous potential in these life-enhancing reconstructions.This review summarizes the initial outcomes of the first four human hand transplants, together with those of the first larynx, bone, knee, nerve and tendon transplants, with special emphasis on the operative technique, graft survival and functional outcomes. The May 2000 Louisville symposium, where these results were presented was undoubtedly a milestone in the history of modern composite tissue allotransplantation. It set the stage for reconstructive and transplant surgeons, researchers, physiotherapists, patients and patient advocates and members of the community to convene and discuss major advances in current composite tissue allotransplantation. The symposium underscored the vital importance of objective evaluation of the status of composite tissue allotransplantation by frank dissemination of details of clinical results and complications of the transplants performed thus far.The composite tissue allotransplantation area is among the newest of transplant areas. The immunology of composite tissue allografts is complex, making tolerance more difficult to achieve than organ tolerance. It needs to be emphasized that any episodes of acute rejection should be prevented for perfect restoration of function and to minimize the risk of chronic rejection in composite tissue allografts. Efficacious, safe and ethical clinical tolerance protocols could improve patient acceptance of composite tissue allografts by providing an alternative to chronic immunosuppression.

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Section: Introductionmentioning

confidence: 99%

Composite Tissue Allotransplantation (CTA): Current Status and Future Insights

et al. 2001

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“…At present, the best preservation strategy clinically used for isolated CTAs is surface cooling. 4,5 Survival of transplanted tissue requires not only cellular protection, but also preservation of the vascular bed.…”

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confidence: 99%

Effect of HTK on the microcirculation in the rat cremaster muscle during warm ischemia and reperfusion

et al. 2005

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Histidine-tryptophan-ketoglutarate (HTK) preserves rat muscle function during cold storage. We examined the effect of HTK perfusion on preservation of microvascular function during 4 h of warm ischemia and subsequent reperfusion (I/R) in the rat cremaster muscle. Leukocyte-endothelium interactions, capillary perfusion, and arteriole diameters were quantified prior to HTK-perfusion and/or ischemia, and at 0, 1, and 2 h after restoration of blood flow. In all groups, the number of rolling leukocytes increased with time, whereas I/R induced a slight increase in leukocyte adhesion. After ischemia, capillary perfusion rapidly recovered to about 50% and returned to near normal (90%) after 2 h. HTK at 22 degrees C did not affect the assessed microcirculation variables, whereas HTK at 4 degrees C reduced leukocyte rolling, but not adhesion. Therefore, microvascular function of HTK-perfused muscles was not better preserved during warm I/R than that of nonperfused muscles. Contrary to other preservation solutions, HTK perfusion in itself was not detrimental to the microcirculation.

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“…El ACV consiste en el trasplante de diferentes tejidos complejos que pueden contener piel, mús-culo, hueso, cartílago, nervios, vasos sanguíneos, células inmunes o una combinación de estos [1][2][3][23][24][25] . Los modelos animales de ACV, permiten no sólo obtener entrenamiento microquirúrgico y estudiar la factibilidad técnica de estos trasplantes, sino también establecer plataformas para la investigación en ACV 26 .…”

Section: Discussionunclassified

Entrenamiento microquirúrgico básico para realizar un modelo animal de alotrasplante compuesto vascularizado

et al. 2013

Rev Chil Cir

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Basic microsurgical training for a vascularized composite allotransplantation animal model Introduction: Rat hind limb transplantation is a complex animal model of vascularized composite allotransplantation (VCA). A basic microsurgical training is required prior to the implementation of this model. Aim: To propose a training program for the acquisition of basic skills to perform a microsurgical VCA model. Animals and Methods: The training program was conducted in two stages. First, at the dry lab, basic suturing skills with 9-0 to 11-0 nylon sutures were practiced, reproduced from surgical videos performed by experts. In a second stage, at the wet lab using 13 Lewis rats, 6 hind limb microsurgical dissections were performed and the important steps for transplantation were identified: 10 end to end femoral artery anastomoses with 10-0 nylon interrupted suture; 10 end to end femoral vein anastomoses with 10-0 nylon suture; 3 femoral vein interposition in the femoral artery; 6 end to end sciatic nerve neurorrhaphy; 4 femur osteosynthesis with 21g needle and wire cerclage. Anastomotic patency rate and anastomotic surgical time were recorded. Results: Arterial and venous patency rate was 100 and 90% respectively. Surgical time decreased from 49 to 24 minutes on arterial anastomoses and from 55 to 25 minutes on venous anastomoses after completion

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Past, present, and future research in the field of composite tissue allotransplantation

Cited by 18 publications

References 63 publications

Composite Tissue Allotransplantation (CTA): Current Status and Future Insights

Composite Tissue Allotransplantation (CTA): Current Status and Future Insights

Effect of HTK on the microcirculation in the rat cremaster muscle during warm ischemia and reperfusion

Entrenamiento microquirúrgico básico para realizar un modelo animal de alotrasplante compuesto vascularizado

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