Pasteurized Autologous Bone Graft in Surgery for Bone and Soft Tissue Sarcoma

Manabe, Jun; Ahmed, Adel Refaat; Kawaguchi, Noriyoshi; Matsumoto, Seiichi; Kuroda, Hiroshi

doi:10.1097/00003086-200402000-00042

Cited by 125 publications

(116 citation statements)

References 37 publications

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“…At a mean follow-up of 4.5 years, all the patients were alive and free from any signs of local or systemic recurrence, with the graft united proximally and distally. Our results are comparable with the published results of other techniques of limb salvage and biological reconstruction using recycling of the resected segment [4,12]. We also encountered fewer complications compared to the earlier reports of the same technique [29] (Table 2), including no local recurrence, which we believe is due to the wide en block resection together with the effectiveness of this technique in destruction of the tumour cells.…”

Section: Discussionsupporting

confidence: 88%

“…Various techniques for reconstruction of the bony and soft tissue defect following resection of malignant bone tumours have been described including the use of endoprosthesis [8,[19][20][21], autograft [23], allograft [18], distraction osteogenesis [28] or recycling of the resected segment by a variety of methods including autoclaving [5], freezing [14], Pasteurisation [1,12] or extracorporeal irradiation [4].…”

Section: Introductionmentioning

confidence: 99%

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Reimplantation of the resected tumour-bearing segment after recycling using liquid nitrogen for osteosarcoma

Rahman

Bassiony

Shalaby

2009

International Orthopaedics (SICOT)

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Reconstruction after en block resection of malignant tumours is still the subject of debate. We questioned the effectiveness of reconstruction by reimplanting the tumourbearing segment after recycling in liquid nitrogen. Ten patients with osteosarcoma around the knee were included, with a mean age of 21 years. The operative technique included wide en bloc excision, debridement, and management of the resected segment with liquid nitrogen followed by reimplantation and internal fixation. At a mean follow-up of 4.5 years there was no local or systemic recurrence and the mean functional score was 82.4%. The frozen graft united proximally and distally in all but one patient in a period ranging from six to ten months. The effectiveness of this reconstruction technique in properly selected patients with osteosarcoma is comparable to other techniques of biological reconstruction with the added benefit of being simple, cheap and durable.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Reimplantation of the resected tumour-bearing segment after recycling using liquid nitrogen for osteosarcoma

Rahman

Bassiony

Shalaby

2009

International Orthopaedics (SICOT)

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“…The intercalary tumour resection results in a segmental bone defect and can represent a challenging reconstructive problem. The surgical options for reconstructing these defects include biologic reconstructions such as an allograft [1][2][3], nonvascularised or vascularised fibular grafts [4,5], autogenous extracorporeally-treated bone [6][7][8][9][10], bone transport [11,12] or the combination of an allograft with vascularised fibular grafts. Nonbiologic reconstructions, on the other hand, use intercalary endoprostheses [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Intercalary frozen autograft for reconstruction of malignant bone and soft tissue tumours

Zekry

Yamamoto

Hayashi

et al. 2017

International Orthopaedics (SICOT)

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Purpose In 1999, we developed a technique using frozen autografts-tumour-containing bone treated with liquid nitrogen-for the reconstruction of malignant bone tumours. The purpose of this study was to evaluate the functional and oncological outcomes of frozen autografts for intercalary reconstruction of malignant bones and soft tissue tumours. Methods This retrospective study was designed to assess 34 patients of mean age 35 (range, 6-79) years. The mean followup period was 62 (24-214) months. The median length of the frozen autografts was 138.4 ± 60.39 (50-290) mm. Results Postsurgically, 20 patients remained disease-free, seven patients survived with no evidence of disease, five patients were alive with disease, and two patients died of disease. The five-and ten-year survival rates of the frozen autografts were 91.2% and the mean International Society of Limb Salvage score was 90%. Complete bony union was achieved in 97% of the patients. There were five cases of nonunion, six cases of fracture, two cases of deep infection and four cases of local recurrence. Conclusion Utilizing intercalary frozen autografts for patients with a nonosteolytic primary or secondary bone tumour without involvement of the subchondral bone is a good alternative treatment, because it is a straightforward biological technique and can provide excellent limb function.

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“…Reconstructions with allografts are being performed in some countries, but the procedure is not acceptable in certain Asian countries, particularly in Japan, because of socio-religious reasons. Therefore, in order to offer patients another alternative, various devitalizing methods, including irradiation [32], autoclaving [12,31], and pasteurization [16] have been investigated to enable re-use of resected tumor-containing bone in joint reconstruction.…”

mentioning

confidence: 99%

“…The advantages of our freezing method include the following: simplicity, osteoinduction, osteoconduction, a perfect fit, sufficient biomechanical strength, and induced cryoimmunological anti-tumor effects [20,36]. Unfortunately, joints that have been reconstructed with frozen autografts may later develop osteoarthritic changes, a complication that also can occur following other biological reconstructions [16,37].…”

mentioning

confidence: 99%

Vitreous preservation of articular cartilage from cryoinjury in rabbits

et al. 2012

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【Abstract】Frozen osteoarticular grafts treated with liquid nitrogen are utilized for joint reconstruction after tumor resection, but the joints may subsequently develop osteoarthritic changes. To preserve articular cartilage from cryoinjury, we modified a vitrification method utilized for embryo cryopreservation and demonstrated in vitro that our vitrification protocol was effective for protecting cartilage from cryoinjury. In this study, we investigated in vivo whether this vitrification method could protect against

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Pasteurized Autologous Bone Graft in Surgery for Bone and Soft Tissue Sarcoma

Cited by 125 publications

References 37 publications

Reimplantation of the resected tumour-bearing segment after recycling using liquid nitrogen for osteosarcoma

Reimplantation of the resected tumour-bearing segment after recycling using liquid nitrogen for osteosarcoma

Intercalary frozen autograft for reconstruction of malignant bone and soft tissue tumours

Vitreous preservation of articular cartilage from cryoinjury in rabbits

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