Patchouli oil isolated from the leaves of <i>Pogostemon cablin</i> ameliorates ethanol-induced acute liver injury in rats <i>via</i> inhibition of oxidative stress and lipid accumulation

Huang, Qionghui; Wu, Xue; Chen, Xiaohong; Wu, Jingsong; Su, Zi-Ren; Liang, Jia-Li; Li, Yucui; Lai, Xiaoping; Chen, Jiannan; Liu, Yuhong

doi:10.1039/c8ra02422g

Cited by 18 publications

(12 citation statements)

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“…It is frequently used for essential oils products [ 13 , 14 ]. The plant is mainly cultivated in Southeast Asia and is commercially used in perfumes and aromatherapy [ 14 , 15 ]. Patchouli essential oil (PEO) recently received much attention due to its diverse bioactivity including anti-inflammatory effects, antiviral activities, antioxidant effects, wound healing, and inhibitory effects on lipid accumulation [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…The plant is mainly cultivated in Southeast Asia and is commercially used in perfumes and aromatherapy [ 14 , 15 ]. Patchouli essential oil (PEO) recently received much attention due to its diverse bioactivity including anti-inflammatory effects, antiviral activities, antioxidant effects, wound healing, and inhibitory effects on lipid accumulation [ 15 , 16 , 17 ]. Patchouli has also been reported to suppress food intake and weight gain [ 18 ], while the major volatile compounds of PEO were characterized such as patchouli alcohol, α -patchoulene, and β -patchoulene [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Inhalation of Patchouli (Pogostemon Cablin Benth.) Essential Oil Improved Metabolic Parameters in Obesity-Induced Sprague Dawley Rats

et al. 2020

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This study investigated effects of patchouli essential oil (PEO) inhalation on metabolic parameters. First, to characterize aromatic compounds in PEO, solid-phase microextraction-gas chromatography/mass spectrometric detection was employed in which 19 aromatic compounds were identified. In GC-olfactometry analysis, linalool, α-patchoulene, and β-patchoulene were found to be the constituents exhibiting the highest similarity to the aromatic compounds in patchouli. In an animal experiment using Sprague Darley rats, groups with PEO inhalation had a reduced food intake compared to the control group. Additionally, body weight was lower in the obesity-induced animal model exposed to PEO inhalation than the group without PEO. However, we found no significant difference in organ weights between groups. In our serum analysis, high-density lipoprotein cholesterol was significantly higher in the PEO inhalation groups, while low-density lipoprotein cholesterol content was highest in the positive control group, suggesting that inhalation of the aromatic compounds present in patchouli may improve cholesterol profile. In addition, leptin levels were reduced in the groups treated with PEO inhalation, which explains the differences in food intake and body weight gains. Last, animal groups exposed to PEO inhalation showed a relatively lower systolic blood pressure which suggests that inhalation of PEO (or aromatic compounds therein) may assist in regulating blood pressure. Collectively, our data demonstrate that the inhalation of PEO influenced certain markers related to metabolic diseases, hence provide basic data for future research as to preventive/therapeutic applications of PEO as well as their aromatic constituents.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhalation of Patchouli (Pogostemon Cablin Benth.) Essential Oil Improved Metabolic Parameters in Obesity-Induced Sprague Dawley Rats

et al. 2020

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“…Besides that, β-caryophyllene was also found to improve cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner (Calleja et al, 2013[ 17 ]). Seychellene, α-bergamotene and valencene were found to have high antioxidant, anti-inflammatory and also anti-apoptotic properties against chemical-induced toxicity in rats (Huang et al, 2018[ 40 ]; Su et al, 2012[ 77 ]; Tsai et al, 2010[ 81 ]; Tsoyi et al, 2011[ 82 ]).…”

Section: Discussionmentioning

confidence: 99%

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Rashid

Hussan

Hamid

et al. 2020

EXCLI Journal; 19:Doc1246; ISSN 1611-2156

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“…According to GC-MS analysis, the most abundant ingredient is patchouli alcohol, with a content of 34.3 %. It has been revealed that patchouli alcohol does a variety of pharmacological activities including anti-oxidation, anti-inflammatory, and antilipogenesis [11,28,29], and these activities are associated with the treatment of NAFLD. Thus, the effect of PO against NAFLD might be related to the content of patchouli alcohol in PO, and patchouli alcohol might act as the main active ingredient.…”

Section: Discussionmentioning

confidence: 99%

“…PO is the essential oil extracted from the dry leaves of Pogostemon cablin with multiple biological activities such as anti-oxidation and anti-inflammation [9,10]. In our previous study, we found that PO has obvious protective effect against hepatic lipidosis in alcoholic liver disease [11]. Itʼs indicated that PO might be able to protect the liver from hepatic steatosis.…”

Section: Introductionmentioning

confidence: 99%

Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis

Luo

et al. 2020

Planta Med

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis is the earliest stage of NAFLD, which is characterized by an accumulation of hepatic lipids. Patchouli oil (PO), which is isolated from the well-known Chinese herb named Pogostemon cablin (Blanco) Benth. (Lamiaceae), inhibits hepatic lipid accumulation effectively. However, its potential ability for the treatment of NAFLD had not been reported before. Thus, the objective of this study was to investigate the effectiveness of PO against hepatic steatosis and its underlying mechanisms. We used a high fat diet (HFD)-induced hepatic steatosis model of rats to estimate the effect of PO against NAFLD. Hematoxylin-eosin and oil red O staining were used to analyze the hepatic histopathological changes. ELISA, RT-qPCR, and Western blotting analysis were applied to evaluate the parameters for hepatic steatosis. Our results showed that PO significantly attenuated the lipid profiles and the serum enzymes, evidenced by quantitative and histopathological analyses. It also markedly down-regulated the expression of sterol regulatory element-binding protein 1 (SREPB-1c) with its downstream factors in de novo lipogenesis. And, likewise, in lipid export by very low-density lipoproteins (VLDL), related molecules were dramatically improved. Furthermore, PO observably normalized the aberrant peroxisome proliferator-activated receptor α (PPAR-α) signal in fatty acids oxidation. In conclusion, PO exerted a preventing effect against HFD-induced steatosis and might be due to decrease de novo lipogenesis, promote export of lipids, as well as owing to improve fatty acids oxidation.

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Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

Abstract: Excessive alcohol consumption can cause serious hepatic injury which is associated with oxidative stress and fatty metabolic disturbance.

Cited by 18 publications

References 54 publications

Inhalation of Patchouli (Pogostemon Cablin Benth.) Essential Oil Improved Metabolic Parameters in Obesity-Induced Sprague Dawley Rats

Inhalation of Patchouli (Pogostemon Cablin Benth.) Essential Oil Improved Metabolic Parameters in Obesity-Induced Sprague Dawley Rats

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis

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