Patent Ductus Arteriosus, Low Platelets, Cyclooxygenase Inhibitors, and Intraventricular Hemorrhage in Very Low Birth Weight Preterm Infants

Brunner, Barbara; Hoeck, Michaela; Schermer, Elisabeth; Streif, Werner; Kiechl‐Kohlendorfer, Ursula

doi:10.1016/j.jpeds.2012.12.035

Cited by 35 publications

(24 citation statements)

References 28 publications

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“…Brunner et al [13] reported on a cohort of 325 VLBW infants (<32 weeks). Data were prospectively collected.…”

Section: Discussionmentioning

confidence: 99%

“…In a logistic regression model, a platelet count ≤150 × 10 9 /l was identified as an independent predictor of hemodynamically significant PDA (HSPDA). Several investigators [8,9] have confirmed the findings of Echtler et al [7], whereas others produced discordant observations which do not suggest that early thrombocytopenia consistently results in HSPDA [10,11,12,13]. Additional series of patients are required to resolve this controversy.…”

Section: Introductionmentioning

confidence: 96%

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Platelet Counts in the First Seven Days of Life and Patent Ductus Arteriosus in Preterm Very Low-Birth-Weight Infants

et al. 2014

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Background: Decreased platelet number and/or function are related to patent ductus arteriosus (PDA) in mice. Whether this is also the case in human infants remains controversial. Objectives: To investigate the association between platelet count nadir within the first 7 days of life and the rate of hemodynamically significant PDA (HSPDA), as well as the rate of response to the treatment with cyclooxygenase (COX) inhibitors. Methods: This is a retrospective study of a cohort of 194 very low-birth-weight (VLBW) infants (<1,500 g) with gestational age <30 weeks. HSPDA was assessed by echocardiography on day 3 of life. Results: HSPDA was present in 105 infants (54.1%). Of these, 101 were treated with COX inhibitors. The treatment failure rate was 21.8%. Median platelet count nadir and rate of thrombocytopenia - defined as platelet count <150 × 10⁹/l and graded as mild (100 to <150 × 10⁹/l), moderate (50 to <100 × 10⁹/l) or severe (<50 × 10⁹/l) - within the first 2 days of life were not significantly associated with the presence of HSPDA on day 3. Moreover, low platelet counts, either on days 1-2 or 3-7, were not significantly associated with the rate of response to treatment with COX inhibitors. Conclusions: Our data provide further evidence for the lack of association between platelet counts within the first days of life and either spontaneous or pharmacological closure of the ductus arteriosus in VLBW infants.

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“…Brunner et al [13] reported on a cohort of 325 VLBW infants (<32 weeks). Data were prospectively collected.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Platelet Counts in the First Seven Days of Life and Patent Ductus Arteriosus in Preterm Very Low-Birth-Weight Infants

et al. 2014

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“…Recent data showed that thrombocyte dysfunction and thrombocyte coagulation disorders may play an important role in the occurrence of IVH. 29 Currently, the combination of thrombocytopenia and thrombocyte dysfunction is known to be an important factor in the high incidence of IVH in premature infants. Studies on adhesion, aggregation, and activation of thrombocytes showed that thrombocyte hyporeactivity lasted until 3-4 days after birth in aterm or premature infants.…”

Section: Discussionmentioning

confidence: 99%

The relationship between thrombocytopenia and intraventricular hemorrhage in neonates with gestational age <35 weeks

Yulandari

Rundjan

Kadim

et al. 2016

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“…The PGE 2 binding to the 3G-protein-coupled receptor activates the adenylate cyclase enzyme and K-ATP channels through a cAMP mechanism, so that vasculature in the DA smooth muscle dilates. [26][27][28][29] Cyclic guanosine monophosphate (cGMP) can activate cGMP kinase which can cause K + cell membrane opened directly. This opening leads to K + efflux from the cell, depolarization of cell membranes, and blocking of the Ca + channels.…”

Section: Discussionmentioning

confidence: 99%

“…As such, sensitivity to PGE 2 is high so that the DA remains open. [26][27][28][29] Based on basic mechanism of PGE 2 , we know that decreased activity of one or all receptor PGE 2 (EP 2 , EP 3 and EP 4 ) may trigger maturation process and spontaneous closure of DA. Decreased PGE 2 receptor (such as EP 4 ) or HPGD may also dramatically lower the patency of DA.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin E2 and patent ductus arteriosus in premature infants

Kaban¹,

Yanuarso²,

Djer³

2016

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Patent Ductus Arteriosus, Low Platelets, Cyclooxygenase Inhibitors, and Intraventricular Hemorrhage in Very Low Birth Weight Preterm Infants

Cited by 35 publications

References 28 publications

Platelet Counts in the First Seven Days of Life and Patent Ductus Arteriosus in Preterm Very Low-Birth-Weight Infants

Platelet Counts in the First Seven Days of Life and Patent Ductus Arteriosus in Preterm Very Low-Birth-Weight Infants

The relationship between thrombocytopenia and intraventricular hemorrhage in neonates with gestational age <35 weeks

Prostaglandin E2 and patent ductus arteriosus in premature infants

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