Patented biological approaches for the therapeutic modulation of the 37 kDa/67 kDa laminin receptor

Abstract

Molecular tools such as antibodies directed against LRP/LR have the potential to act as promising alternative therapeutics for the treatment of various diseases.

Structural and mechanistic commonalities of amyloid-β and the prion protein

“…94 LRP/LR is a transmembrane (TM) receptor (TMR) which is located at the cholesterol-rich lipid rafts and may employ HSPGs to mediate its binding interactions. 31,32 Aβ oligomers, as previously stated, have been shown to bind to an array of TM receptors and HSPGs or are alternatively inserted to lipid raft domains of the plasma membrane. Furthermore, the 37 kDa/67 kDa LRP/ LR binds laminin (to which Aβ oligomers similarly bind), as well as PrP c (a protein to which Aβ oligomers bind with high affinity).…”

“…31,32,113 Two forms of the protein exist: the normal cellular prion protein (PrP c ) and the infectious form (PrP Sc ), the latter is considered the causative agent of TSEs.…”

“…67 The Aβ-laminin interaction has been demonstrated to promote neurite outgrowth 68 and inhibit fibrillogenesis. the 40S ribosomal subunit and protein synthesis 31,32 and in the nucleus in which it is associated with histones H2A, H2B and H4. 94 LRP/LR is a transmembrane (TM) receptor (TMR) which is located at the cholesterol-rich lipid rafts and may employ HSPGs to mediate its binding interactions.…”

Anti-LRP/LR-Specific Antibody IgG1-iS18 Significantly Impedes Adhesion and Invasion in Early- and Late-Stage Colorectal Carcinoma Cells

“…Previous studies have proven that numerous cancerous cell lines display overexpressed levels of 37kDa/67kDa LRP/LR (23)(24)(25). This suggests that the interaction between LRP/LR and laminin-1 may be essential for tumorigenic cells to transform into malignant cancers.…”

“…Furthermore, it has been found that LRP/LR exhibits a high affinity for laminin-1, an essential element of the basement membrane (22). Laminin-1 is a noncollagenous, heterotrimeric glycoprotein that is able to bind to the extracellular matrix (ECM) (23). Therefore, laminin-1 functions as a key player in enhancing biological processes such as cell adhesion, homing (24), polarity, migration, proliferation, differentiation (25) and neutrite outgrowth (26).…”