Pathobiology of Gastric Carcinoids and Adenocarcinomas in Rodent Models and Patients: Studies of Gastrocystoplasty, Gender-Related Factors and Autophagy

Expression and clinical significance of Beclin-1 in gastric cancer tissues of various clinical stages

“…However, in cancer, the role of autophagy is more complex (19). Various preclinical and clinical studies have thus been undertaken, aiming to develop therapeutic agents targeting autophagy (14)(15)(16)(17)(18)(19)(20). However, compared with apoptosis, data indicating an association between cancer pathogenesis and autophagic cell death are limited (21,22).…”

“…no. sc-2004; 1:5,000 dilution; Santa Cruz Biotechnology, Inc., Dallas, TX, USA) at room temperature for 1 h. Blots were visualized using enhanced chemiluminescence detection reagents and then exposed to X-ray film (Thermo Fisher Scientific, Inc.) (17,18).…”

Biology and Diseases of Other Rodents

“…Mastomys natalensis spontaneously develops gastric carcinoid and serves as a model for Zollinger Ellison syndrome in humans (Kumazawa et al, 1989;Nilsson et al, 1992;Vigen et al, 2012). The role of hypergastrinemia in tumor production, as well as CCK-A and CCK-B/gastrin receptors on enterochromaffin-like carcinoid cells and their relationship to histamine secretion have been well studied (Kolby et al, 1998;Vigen et al, 2012).…”

“…Colonies of M. natalensis have been established by many of the scientists that use them, and inbred lines varying in susceptibility to gastric carcinoids have been developed (Kneidinger, 2008;Randeria, 1978;Vigen et al, 2012). Under field conditions M. natalensis eats mostly grass and other seeds (Nowak, 1999).…”