Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

Zumaya-Estrada, Federico A.; Rodríguez, M. C.; Rodrı́guez, Mario H.

doi:10.21149/8140

Cited by 5 publications

(2 citation statements)

References 58 publications

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“…Hence, the triatomines with the presence of the parasite Trypanosoma cruzi have a clear footprint that makes them distinguishable from others. Studies conducted with different species of triatomines have shown that the parasite generates metabolic changes in the insect (IEEE Staff 2010; Zumaya-Estrada et al 2018; Erny and Masuda 2022), due to interactions between the insect intestine and the parasite in its different life stages.…”

Section: Discussionmentioning

confidence: 99%

Differentiation smelling footprints of the Chagas disease vector using an electronic nose based on artificial intelligence algorithms

Ruiz-Jiménez,

Sierra,

Ortega B

et al. 2024

Preprint

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The present study aims to present the design of an electronic nose capable of learning and differentiating semiochemical signals emitted by insects usable to identify species that transmit Chagas disease. The proposed device used different non-specific resistor gas sensors integrated into a system of artificial intelligence models. To validate the nose, we used eight insect species of the Triatominae subfamily and one population that was a natural carrier of the parasite Trypanosoma cruzi. Also, the discriminatory capacity of distant species was tested with other insects like Aedes aegypti (arbovirus vector) and Sitophilus oryzae (stored grains plague). As a result, the electronic nose was able to differentiate up to gender level with an accuracy of 89.64% and to differentiate Rhodnius pallensces naturally infected with T. cruzi with less than 1% of error in classification. These results show that our designed device can detect particular smelling footprints, and one electronic nose like that could be a tool to discriminate against insects in the future

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Section: Discussionmentioning

confidence: 99%

Differentiation smelling footprints of the Chagas disease vector using an electronic nose based on artificial intelligence algorithms

Ruiz-Jiménez,

Sierra,

Ortega B

et al. 2024

Preprint

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“…Some successful examples against transmission of Plasmodium berghei by Anopheles stephensi (108), P. vivax (109) by A. dirus (110), P. falsiparum by A. gambiae (111), and Leishmania infantum by Lutzomyia longipalpis (112) have been reported in the literature, showing this strategy as promising and possibly helpful in interrupting distinct pathogen transmission cycle. Notwithstanding the potential of TBVs, they do not directly protect humans, so there is resistance to their use in public health programs (113). In 1980, there were about 95 species of arboviruses cataloged in Brazil alone, but this number has doubled in the last three decades and today 210 arboviruses circulate in the country.…”

Section: Immunoprophylactic and Biological Control Approachesmentioning

confidence: 99%

Historical Perspective and Biotechnological Trends to Block Arboviruses Transmission by Controlling Aedes aegypti Mosquitos Using Different Approaches

et al. 2020

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Continuous climate changes associated with the disorderly occupation of urban areas have exposed Latin American populations to the emergence and reemergence of arboviruses transmitted by Aedes aegypti. The magnitude of the financial and political problems these epidemics may bring to the future of developing countries is still ignored. Due to the lack of effective antiviral drugs and vaccines against arboviruses, the primary measure for preventing or reducing the transmission of diseases depends entirely on the control of vectors or the interruption of human-vector contact. In Brazil the first attempt to control A. aegypti took place in 1902 by eliminating artificial sites of eproduction. Other strategies, such as the use of oviposition traps and chemical control with dichlorodiphenyltrichlorethane and pyrethroids, were successful, but only for a limited time. More recently, biotechnical approaches, such as the release of transgenics or sterile mosquitoes and the, development of transmission blocking vaccines, are being applied to try to control the A. aegypti population and/or arbovirus transmission. Endemic countries spend about twice as much to treat patients as they do on the prevention of mosquito-transmitted diseases. The result of this strategy is an explosive outbreak of arboviruses cases. This review summarizes the social impacts caused by A. aegypti-transmitted diseases, mainly from a biotechnological perspective in vector control aimed at protecting Latin American populations against arboviruses.

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Kissing Bugs (Triatominae)

Fuentes-Vicente

Gutiérrez-Cabrera

2022

Encyclopedia of Infection and Immunity

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Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

Cited by 5 publications

References 58 publications

Differentiation smelling footprints of the Chagas disease vector using an electronic nose based on artificial intelligence algorithms

Differentiation smelling footprints of the Chagas disease vector using an electronic nose based on artificial intelligence algorithms

Historical Perspective and Biotechnological Trends to Block Arboviruses Transmission by Controlling Aedes aegypti Mosquitos Using Different Approaches

Kissing Bugs (Triatominae)

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