Pathogenese des Pruritus

Ständer, Sonja; Raap, Ulrike; Weißhaar, Elke; Schmelz, Martin; Mettang, Thomas; Handwerker, Hermann O.; Luger, Thomas A.

doi:10.1111/j.1610-0387.2011.07585_suppl.x

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…It has been shown that the impact on quality of life due to chronic pruritus is comparable to the impact of the chronic pain syndrome [5]. Pruritus and pain are complex sensations with both common and differing signaling pathways and characteristics [6]. The well‐known observation that scratching‐induced pain improves or temporarily abolishes pruritus demonstrates this.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies, for example, demonstrate that mechanosensitive pain neurons can transmit pruritus. In central imaging corresponding brain regions can be activated by pain and pruritus, and pruritus‐specific brain regions do not appear to exist [6]. Possible differences exist with respect to the activation of central motor areas.…”

Section: Introductionmentioning

confidence: 99%

“…Possible differences exist with respect to the activation of central motor areas. The simultaneous motor activation in pruritus might correlate with planning the scratch response, while in pain, the stimulated hand is retracted [6]. In a very recent publication it could be shown that heat and pain sensations are stronger in proximal body sites than in distal body sites, while the sensation of itch behaves inversely and is thus more intense in distal body sites such as the hands [7].…”

Section: Introductionmentioning

confidence: 99%

“…mechanosensitive Schmerzneurone Pruritus weiterleiten können. Auch in der zentralen Bildgebung existieren übereinstimmende Hirnareale, die durch Schmerz und Pruritus aktiviert werden, und es scheint kein Pruritus-spezifi sches Hirnareal zu geben [6]. Mögliche Unterschiede existieren bezüglich der [6].…”

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“…Auch in der zentralen Bildgebung existieren übereinstimmende Hirnareale, die durch Schmerz und Pruritus aktiviert werden, und es scheint kein Pruritus-spezifi sches Hirnareal zu geben [6]. Mögliche Unterschiede existieren bezüglich der [6]. Interessanterweise konnte in einer jüngsten Publikation gezeigt werden, dass Wärmeund Schmerzempfi ndungen an proximalen Körperarealen stärker als an distalen Körperarealen sind, wohingegen sich das Juckempfi nden gegensätzlich verhielt und somit an distalen Körperarealen wie an den Händen stärker ausgeprägt war [7].…”

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“The itching hand“– important differential diagnoses and treatment

Weißhaar

Kallen

Weiß

2012

J Deutsche Derma Gesell

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SummarySkin diseases affecting the hands receive particular individual attention and constitute a considerable emotional burden. Many dermatoses also present with itching of the hands. Itch is often underestimated when it occurs in a comparably limited body area such as the hands. The high occupational significance of the hands in many professions must, nevertheless, be stressed. One of the most frequent diagnoses in itching of the hands is eczema. In the differential diagnosis, less common diseases such as neurological and systemic diseases and adverse drug reactions must also be taken into consideration. Itching of the hands can also be accompanied by other sensations, such as burning, stinging and pain. A thorough history regarding sensations and dysesthesias already allows for a diagnostic classification of the disease in some cases. Itching of the hands requires a careful and thorough diagnostic approach. This forms the basis of a specific and successful therapy which may be adapted stepwise, depending on the underlying cause, and also may require, in addition to causal therapy, symptomatic antipruritic therapy. Therapy should follow the current guidelines for chronic pruritus and hand eczema. This article reviews over the differential diagnosis and therapy of "itching hands".

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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“The itching hand“– important differential diagnoses and treatment

Weißhaar

Kallen

Weiß

2012

J Deutsche Derma Gesell

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Prevalence of pruritus in patients with chronic liver disease: A multicenter study

Oeda

Takahashi

Yoshida

et al. 2017

Hepatology Research

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Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

129

116

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Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

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Pathogenese des Pruritus

Cited by 9 publications

References 10 publications

“The itching hand“– important differential diagnoses and treatment

“The itching hand“– important differential diagnoses and treatment

Prevalence of pruritus in patients with chronic liver disease: A multicenter study

Human mast cells and basophils—How are they similar how are they different?

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