Pathogenetic Development Factors of Position-dependent Changes in Oxygen Saturation

Abstract

It is known that the oxygen saturation of the peripheral blood is determined by the efficiency of the heart, the state of the microcirculatorybed, so position-dependent fluctuations in systolic blood pressure, pressure in the left renal and left adrenal veins,mediated bursts of hormones of the adrenal cortex can affect SO2. There is every reason to believe that SO2 will change in differentstatic positions. Aim. To study position-dependent changes in oxygen saturation based on the study of the pathogenetic effect of venous bloodflow in the “pool” of the left renal vein on the general hemodynamics and hormones of the adrenal cortex. Material and methods. A method for the polypositional assessment of oxygen saturation disturbances in six static states has beendeveloped: standing, sitting, on the back, on the abdomen, on your right side, on your left side. Statistical data processing was carriedout, which made it possible to determine the relationship between the indicators. Results. Polypositional studies of oxygen saturation hemodynamic parameters (SрO2) in six static states revealed the variability ofthe relationships of these groups when comparing them. The correlation was high, statistically significant between diastolic (DBP)and systolic (SBP) pressure, moderate between pulse (Ps) and SBP, pulse and DBP, weak between pulse and saturation. The groupsdivided by body positions relative to the pulse, SBP and DBP did not have a cluster structure. In the pron-position, SO2 had a minimalvalue, significantly different from the data in the other positions. Conclusion. Body position is one of the pathogenetically significant factors regulating blood oxygen saturation, which can helpin the treatment and rehabilitation of patients with respiratory failure (COVID-19). Polypositional saturation measurement in sixstatic states can determine a new, more effective algorithm for the management of patients with respiratory failure, both duringtreatment and during rehabilitation.