Pathologic Classification of Lung Malignancies and Special Pathologic Procedures

Marchevsky, Alberto M.

doi:10.1016/b978-1-4160-3993-8.00022-2

Cited by 1 publication

(2 citation statements)

References 111 publications

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“…Sarcomatoid carcinomas can be difficult to distinguish from large cell carcinoma and pulmonary sarcomas. 27 DD was imposed with primary pulmonary pleomorphic sarcoma, lacking expression to IHC markers of epithelial differentiation. It is difficult to differentiate sarcomatoid carcinomas (SCs) from undifferentiated pleomorphic sarcoma.…”

Section: Differential Diagnosis (Dd)mentioning

confidence: 99%

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Pulmonary sarcomatoid carcinoma - pathohistological and immunohistochemical analysis, prognosis and complex treatment

Marinova¹,

Yordanova²,

Evgeniev³

2021

JLPRR

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The pulmonary sarcomatoid carcinoma (PSC) is extremely rarely lung neoplasm. A woman at the age of 55 with a local advanced pulmonary sarcomatoid carcinoma of the right lung and CT data on bilateral adrenal metastases and three brain metastases were established. Diagnosis is placed after bronchoscopy with biopsy and detailed pathochistological and immunohistochemical analysis. PSC is extremely malignant and with high risk of distant haematogenic metastases. This rare clinical case support the need for strict pathohistological and immunohistochemical analysis, a difficult pathohistological differential diagnosis with other primary malignant lung tumors and the assessment of complex treatment. In order to improve the healing results and survival of patients, timely diagnosis is required at early stage with surgical treatment and subsequent adjuvant chemotherapy and targetеd therapy after genetic analysis of surgery or biopsy tissue material.

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Section: Differential Diagnosis (Dd)mentioning

confidence: 99%

“…28 The distinction between a large cell carcinoma and a sarcomatoid carcinoma is based on the perception of epithelial differentiation features. 27 Pleomorphic leiomiosarcoma is characterized by smooth muscle differentiation, and pleomorphic liposarcoma with lipoblasts, often S100 + or Smooth Muscle Actin (SMA)+. 17…”

Section: Differential Diagnosis (Dd)mentioning

confidence: 99%