Pathological alterations in the expression status of rotator cuff tendon matrix components in hyperlipidemia

Fang, William; Sekhon, Seerat; Teramoto, Darren; Fung, Cameron; La, Vy; Duong, Cindy; Doescher, Christian; Thai, An; Thankam, Finosh G.; Agrawal, Devendra K.

doi:10.1007/s11010-022-04643-6

Cited by 5 publications

(5 citation statements)

References 60 publications

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“…This is observed in injured tendons and actively remodeling tendons [ 28 , 29 ]. While fat get deposited in the tendon tissue, presence of inflammatory cells is reported, and integrity of tendon is disrupted, but the mechanism of initial trigger is still unclear [ 30 – 33 ]. With time and further addition of lipids, it invites a cascade of events that unfolds the inflammation and further weakens the tendons by altering tendon ECM and collagen fibrils.…”

Section: Discussionmentioning

confidence: 99%

“…The animals were fed twice every day with 12/12 hours of light-dark cycle. At 40 weeks, swines were sacrificed, and the Achilles tendon tissues were collected and stored at −80°C until testing [ 7 , 9 , 10 ]. On the day of testing the tendon tissues were thawed using a two-step protocol: (i) 4 h at 4°C, and (ii) 2 h at room temperature [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

“…Hence, researchers are keenly interested in understanding the association between hyperlipidemia and changes in Achilles tendons to explore new avenues for treatment. In our previous studies on swine models, we reported that hyperlipidemia induced pathological changes in tendon organization, extracellular matrix (ECM), and cellularity [ 7 ] along with early changes in the mechanical properties of the infraspinatus tendon [ 8 , 9 ]. Our current focus is on studying the changes in the biomechanical properties of the Achilles tendon in swine under a hyperlipidemic diet.…”

Section: Introductionmentioning

confidence: 99%

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Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Lal L.P,

K. Agrawal

2024

J Ortho Sports Med

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Hyperlipidemia is linked to atherosclerosis and various diseases. Its strong association with Achilles tendinopathies and xanthomas affects tendon properties through lipid deposition in tendon tissue. We examined the impact of hyperlipidemia on the biomechanical properties of the swine Achilles tendons. Swines were fed a high-cholesterol-high-fat diet to induce hyperlipidemia, and their Achilles tendons were collected and examined for biomechanical properties. The ultimate tensile strength, modulus of elasticity and viscoelastic properties did not exhibit significant differences between hyperlipidemic and control swines. H&E and pentachrome staining revealed extracellular matrix (ECM) disorganization and cellular infiltration in the hyperlipidemic swines, highlighting a marked difference between the control and hyperlipidemic groups. These results suggest hyperlipidemia in young swines alters the tendon composition and may contribute to weak biomechanical properties with time.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Lal L.P,

K. Agrawal

2024

J Ortho Sports Med

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“…In terms of cell sources, researchers have explored various options for tissue engineering scaffolds in rotator cuff tendon tears. These include tenocytes [ 134 , 135 ], fibroblast [ 136 , 137 ] and stem cells [ 80 , 89 , 138 , 139 ]. The selected cell source should have the potential to differentiate into tenocytes, which are the main cells responsible for tendon regeneration.…”

Section: Treatment Strategies Used For Rotator Cuff Tear Repairmentioning

confidence: 99%

Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury

Rajalekshmi,

K. Agrawal

2024

J Surg Res

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The rotator cuff is a crucial group of muscles and tendons in the shoulder complex that plays a significant role in the stabilization of the glenohumeral joint and enabling a wide range of motion. Rotator cuff tendon tears can occur due to sudden injuries or degenerative processes that develop gradually over time, whether they are partial or full thickness. These injuries are common causes of shoulder pain and functional impairment, and their complex nature highlights the essential role of the rotator cuff in shoulder function. Scar formation is a crucial aspect of the healing process initiated following a rotator cuff tendon tear, but excessive fibrous tissue development can potentially lead to stiffness, discomfort, and movement limitations. Age is a critical risk factor, with the prevalence of these tears increasing among older individuals. This comprehensive review aims to delve deeper into the anatomy and injury mechanisms of the rotator cuff. Furthermore, it will inspect the signaling pathways involved in fibrous tissue development, evaluate the various factors affecting the healing environment, and discuss proactive measures aimed at reducing excessive fibrous tissue formation. Lastly, this review identifed gaps within existing knowledge to advance methods for better management of rotator cuff tendon injuries.

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“…A hyperlipidemic milieu can induce changes in critical components of the ECM in tendon tissues and cells. The mechanism may involve low-density lipoprotein cholesterol (LDL-C) inducing dysfunction of tendon cells, contributing to alterations in the ECM components ( 36 ).…”

Section: Molecular Mechanism Of Rotator Cuff Injury Induced By Hyperl...mentioning

confidence: 99%

Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair

Qian,

Huang,

Wan

et al. 2023

Front. Public Health

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This review delves into the intersection of two prevalent conditions, hyperlipidemia and rotator cuff injuries, both of which bear substantial healthcare burdens. Our investigation begins with an exploration of rotator cuff injuries, common musculoskeletal disorders that severely impair shoulder functionality and quality of life. These injuries are notably pervasive among sports enthusiasts and the older adult, with an incidence rate estimated at 5–10% in the general population. Despite their widespread occurrence and the diverse, multifactorial etiological factors, effective treatment strategies remain elusive. We then examine hyperlipidemia, a metabolic disorder affecting approximately 40% of the global adult population. Characterized by elevated levels of cholesterol and triglycerides, hyperlipidemia can precipitate severe cardiovascular complications and presents a significant socioeconomic burden. Although current management strategies encompass lifestyle modifications and pharmacological interventions, the condition remains a formidable health challenge. Central to this review is the exploration of a potential association between hyperlipidemia and rotator cuff injuries. We aim to synthesize the current understanding of hyperlipidemia’s role in the pathophysiology of rotator cuff injuries, thereby offering fresh insights into their common etiological underpinnings, potential therapeutic targets, and drugs, such as Statins. The influence of other lipid-lowering therapeutics on tendon health is also considered, and further research into the molecular pathways and potential therapeutic benefits of these drugs is required. This pursuit aligns with broader efforts to enhance patient outcomes, minimize healthcare burdens, and contribute to the global understanding of these prevalent conditions.

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Pathological alterations in the expression status of rotator cuff tendon matrix components in hyperlipidemia

Cited by 5 publications

References 60 publications

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine

Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury

Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair

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