Pathological bacterial translocation in liver cirrhosis

Wiest, Reiner; Lawson, Melissa A.; Geuking, Markus B.

doi:10.1016/j.jhep.2013.07.044

Cited by 670 publications

(595 citation statements)

References 191 publications

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“…A number of studies have shown that SIBO is seen more in patients with cirrhosis [18][19][20]. Miele et al found that SIBO had a high prevalence in NAFLD patients compared with normal people [21].…”

Section: Discussionmentioning

confidence: 99%

Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

Rafiei

Bemanian

Rafiei

et al. 2018

Romanian Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

Rafiei

Bemanian

Rafiei

et al. 2018

Romanian Journal of Internal Medicine

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“…Ascites fluid is also the most common site of infection in patients with cirrhosis; spontaneous bacterial peritonitis (SBP) occurs in approximately 3% of outpatients and 10% of inpatients (2). Increased susceptibility of cirrhotic patients to infection is likely multifactorial, a consequence of pathological gut bacterial translocation and impaired/altered immune function (4). Although thought to be caused by gut bacterial translocation, SBP is diagnosed by ascites fluid neutrophil count, as >60% of SBP cases are culture negative, necessitating empirical antibiotic treatment (4).…”

Section: Introductionmentioning

confidence: 99%

CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites

Irvine¹,

Banh²,

Gadd³

et al. 2016

JCI Insight

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“…Deficiencies in the immune system show that both in the innate and adaptive responses, the principal flaws are associated with bactericidal capability, phagocytosis, and opsonization, as well as deficiencies in chemotaxis in both mononuclear and polymorphonuclear cells (PMNs) [6]. PMNs are cells that constitute the first component of innate immune defense.…”

Section: Introductionmentioning

confidence: 99%

Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis

Agraz‐Cibrián

Segura-Ortega

Delgado‐Rizo

et al. 2016

J Infect Dev Ctries

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Introduction: Liver cirrhosis (LC) constitutes one of the main 10 causes of death worldwide. LC has a characteristic asymptomatic compensated phase followed by a progressive decompensated phase, in which diverse complications are presented. LC patients are highly prone to bacterial infections. The neutrophils in these patients present defects in the production of oxygen radicals, which are essential for bacteria elimination as in the activation of neutrophil extracellular traps (NETs). The main objective of this work was to determine the NETs and neutrophil activation markers in LC patients. Methodology: Neutrophil purification was done with Ficoll Histopaque from a sample of the peripheral blood of patients with compensated and decompensated LC. Neutrophils were activated with Phorbol 12-myristate 13-acetate to evaluate the release of NETs by means of fluorescence microscopy and fluorometry, while expression of activation markers (CD69, CD80, perforin, and CAP-18) was evaluated by flow cytometry. Results: A significant decrease in the release capability of NETs was observed as the level of LC in the patient increased. When comparing serum levels in inflammatory cytokines among the different study groups, significant differences were observed. No significant differences were detected on neutrophil activation markers; nevertheless, there was a correlation between diminution of CD69 and CD80 expression in decompensated patients. Conclusions: We demonstrated that LC patients with neutrophil extracellular trap release deficiencies could have an increased rate of complications.

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Pathological bacterial translocation in liver cirrhosis

Cited by 670 publications

References 191 publications

Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

Liver disease symptoms in non-alcoholic fatty liver disease and small intestinal bacterial overgrowth

CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites

Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis

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