Pathological changes of brain oscillations following ischemic stroke

Satō, Yoshimichi; Schmitt, Oliver; Ip, Zachary; Rabiller, Gratianne; Omodaka, Shunsuke; Tominaga, Teiji; Yazdan-Shahmorad, Azadeh; Liu, Jialing

doi:10.1177/0271678x221105677

Cited by 12 publications

(7 citation statements)

References 174 publications

(246 reference statements)

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“…Given previous evidence that oscillatory dynamics are affected by rTMS (Thut et al, 2011;Veniero et al, 2011;Chota et al, 2021) and are closely related to cognitive improvement (Klimesch et al, 1993;Richard Clark et al, 2004;Iliopoulos et al, 2020), we will analyze the power spectrum and functional connectivity of each oscillation within and between hemispheres, between groups, and pre-and post-treatment. Oscillation ratios, such as θ/α ratio, θ/γ ratio, and (α + β)/(θ + δ) ratio will be further analyzed (Coben et al, 1985;Moretti et al, 2013;Sato et al, 2022).…”

Section: Resting Eeg Measurementsmentioning

confidence: 99%

Novel Technologies Targeting the Rehabilitation of Neurological Disorders

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Resting Eeg Measurementsmentioning

confidence: 99%

Novel Technologies Targeting the Rehabilitation of Neurological Disorders

2024

Frontiers Research Topics

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“…The maintenance of ionic gradients and membrane potential of neurons consumes a great amount of energy, thus the reduction of CBF affects significantly brain oscillations. Neurons exhibit an individual vulnerability to hypoxia and the signal power of high frequency waves are first to be decreased at the early stage of stroke ( 8 ). If blood flow is interrupted for more than 20–60 s, synaptic dysfunction occurs, leading to neural function suppression ( 9 ).…”

Section: The Pathological Evolution Of Brain Infarctionmentioning

confidence: 99%

“…However, this neural circuits remodeling might also have detrimental effects. For instance, the disruption of communication among neural networks might consolidate, constituting a putative mechanism of cognitive deficits after stroke ( 8 ).…”

Section: Neurophysiological Changes During the Chronic Phasementioning

confidence: 99%

The role of neurophysiological tools in the evaluation of ischemic stroke evolution: a narrative review

Motolese¹,

Lanzone²,

Todisco³

et al. 2023

Front. Neurol.

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Ischemic stroke is characterized by a complex cascade of events starting from vessel occlusion. The term “penumbra” denotes the area of severely hypo-perfused brain tissue surrounding the ischemic core that can be potentially recovered if blood flow is reestablished. From the neurophysiological perspective, there are local alterations—reflecting the loss of function of the core and the penumbra—and widespread changes in neural networks functioning, since structural and functional connectivity is disrupted. These dynamic changes are closely related to blood flow in the affected area. However, the pathological process of stroke does not end after the acute phase, but it determines a long-term cascade of events, including changes of cortical excitability, that are quite precocious and might precede clinical evolution. Neurophysiological tools—such as Transcranial Magnetic Stimulation (TMS) or Electroencephalography (EEG)—have enough time resolution to efficiently reflect the pathological changes occurring after stroke. Even if they do not have a role in acute stroke management, EEG and TMS might be helpful for monitoring ischemia evolution—also in the sub-acute and chronic stages. The present review aims to describe the changes occurring in the infarcted area after stroke from the neurophysiological perspective, starting from the acute to the chronic phase.

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Section: Resting Eeg Measurementsmentioning

confidence: 99%

Intermittent theta burst stimulation vs. high-frequency repetitive transcranial magnetic stimulation for post-stroke cognitive impairment: Protocol of a pilot randomized controlled double-blind trial

Han

Chen

et al. 2023

Front. Neurosci.

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IntroductionIntermittent theta burst stimulation (iTBS), a novel mode of transcranial magnetic stimulation (TMS), has curative effects on patients with post-stroke cognitive impairment (PSCI). However, whether iTBS will be more applicable in clinical use than conventional high-frequency repetitive transcranial magnetic stimulation (rTMS) is unknown. Our study aims to compare the difference in effect between iTBS and rTMS in treating PSCI based on a randomized controlled trial, as well as to determine its safety and tolerability, and to further explore the underlying neural mechanism.MethodsThe study protocol is designed as a single-center, double-blind, randomized controlled trial. Forty patients with PSCI will be randomly assigned to two different TMS groups, one with iTBS and the other with 5 Hz rTMS. Neuropsychological evaluation, activities of daily living, and resting electroencephalography will be conducted before treatment, immediately post-treatment, and 1 month after iTBS/rTMS stimulation. The primary outcome is the change in the Montreal Cognitive Assessment Beijing Version (MoCA-BJ) score from baseline to the end of the intervention (D11). The secondary outcomes comprise changes in resting electroencephalogram (EEG) indexes from baseline to the end of the intervention (D11) as well as the Auditory Verbal Learning Test, the symbol digit modality test, the Digital Span Test findings, and the MoCA-BJ scores from baseline to endpoint (W6).DiscussionIn this study, the effects of iTBS and rTMS will be evaluated using cognitive function scales in patients with PSCI as well as data from resting EEG, which allows for an in-depth exploration of underlying neural oscillations. In the future, these results may contribute to the application of iTBS for cognitive rehabilitation of patients with PSCI.

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Pathological changes of brain oscillations following ischemic stroke

Cited by 12 publications

References 174 publications

Novel Technologies Targeting the Rehabilitation of Neurological Disorders

Novel Technologies Targeting the Rehabilitation of Neurological Disorders

The role of neurophysiological tools in the evaluation of ischemic stroke evolution: a narrative review

Intermittent theta burst stimulation vs. high-frequency repetitive transcranial magnetic stimulation for post-stroke cognitive impairment: Protocol of a pilot randomized controlled double-blind trial

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