Pathological Changes of Gentamicin in Liver Tissue and Antioxidant Property of Cinnamon Extract on Wistar Rats

Najafian, Mahmood; Haleh, Mokaber; Pourahmadi, Mohammad; Mohsen, Farzam; Jahromi, Hossein Kargar

doi:10.13005/bpj/496

Cited by 16 publications

(16 citation statements)

References 17 publications

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“…The coadministration of natural products with GM may be helpful. 8,34,35 The present study was designed to evaluate the protective capacity and ameliorating effects of TV and RM extracts on GMinduced liver toxicity and dyslipidemia, respectively. Our data demonstrated that GM administration significantly damaged liver cells as manifested by a large increase in ALT and AST activities and total bilirubin level.…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats

et al. 2017

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Rosemary ( Rosmarinus officinalis; RM) and thyme ( Thymus vulgaris; TV) are used as remedies. We designed this work to investigate the preventive effect of aqueous extracts of RM or TV on the gentamicin (GM)-induced hepatotoxicity and abnormalities of lipid profile in rats. Both plant extracts exhibited an in vitro antioxidant activity as determined by the 1,1-diphenyl-2-picrylhydrazyl assay. Radical scavenging activity for TV extract was 48.7% and for RM extract was 25.6%. Polyphenolic determination by high-performance liquid chromatography for both extracts revealed that catechin, coumarin, cinnamic acid and rutin were detected in both extracts. RM extract had higher values than TV extract in all except rutin. Ferulic acid and quercetin were also detected in TV extract and sinapic acid and oleuropein were detected in RM extract. In rats given GM intraperitoneally for 10 days and coadministered either RM extract or TV extract orally, both aqueous extracts demonstrated similar hepatoprotective effects manifested by approximate normalization of plasma liver enzymes (AST and ALT), bilirubin level and total protein concentration compared with the group given GM only. Abnormal lipid parameters and raised hydrogen peroxide levels were ameliorated by both extracts. Pancreatic lipase activity was markedly reduced by RM extract. Also, the atherogenic index value was significantly reduced by both extracts as compared to that of GM group. DNA fragmentation analysis confirmed tissue damage by GM and its amelioration by the extracts. These findings suggest that RM and TV extracts could be helpful in ameliorating some aspects of gentamicin toxicity.

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Section: Discussionmentioning

confidence: 99%

Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats

et al. 2017

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“…Antioxidant compounds have played effective roles in the decline of kidney and liver injuries induced by the use of gentamicin. Oxidative stress is one of the agents responsible for renal and liver injury (Wang et al, 2004;Tavafi, 2013;Mahmood et al, 2014). Gentamicin has caused severe renal injuries in rats, which were revealed by a marked elevation in both the plasma BUN and creatinine and histopathological changes in the proximal tubule cells.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence has indicated that the hepatotoxicity of gentamicin subsequently leads to necrosis and degenerative changes in the hepatocytes (Stojiljkovic and Stoiljkovic, 2006;Nayma et al, 2012;Mahmood et al, 2014;Masakazu et al, 2014). In this study, gentamicin-administered groups (Group IV) showed remarkable degenerative changes and necrosis in the hepatocytes; mononuclear cells had infiltrated within portal areas and proliferation of Kupffer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Aminoglycoside antibiotic gentamicin sulphate is frequently used for the treatment of Gram-negative bacteria such as Pseudomonas, Proteus, and Serratia (Corona et al, 2014;Shrestha and Haylor, 2014). It has been a most powerful therapeutic drug against bacterial strains that are resistant to other antibiotics in many conditions; however, its use is limited due to the side effects of nephrotoxicity and hepatotoxicity (Martínez-Salgado et al, 2007;Nayma et al, 2012;Mahmood et al, 2014). When the effects of gentamicininduced nephrotoxicity are not completely known, suggested pathological effects include induction of apoptosis, necrosis, oxidative stress, an increase in monocyte/macrophages infiltration, and elevation of endothelin I (Sumbul et al, 2003;Süzgec et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Helichrysum plicatum DC. subsp. plicatum ethanol extract on gentamicin-induced nephrotoxicity in rats

Yıldırım

Kordalı

Kapakin

et al. 2017

J. Zhejiang Univ. Sci. B

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The aim of this study was to evaluate the possible therapeutic or protective effects of Helichrysum plicatum DC. subsp. plicatum ethanol extract (HPE) against gentamicin-induced nephrotoxicity. Thirty-six Sprague Dawley male rats weighing between 200 and 250 g were used as live material. They were formed into six groups containing 6 rats each and were allowed to adapt to laboratory conditions for 7 d. Group I: control, 5% DMSO intraperitoneal (i.p.); Group II: HPE 100 mg/(kg·d) i.p.; Group III: HPE 200 mg/(kg·d) i.p.; Group IV: gentamicin as 80 mg/(kg·d) i.p.; Group V: gentamicin as 80 mg/(kg·d) i.p.+HPE 100 mg/(kg·d) i.p.; and Group VI: gentamicin as 80 mg/(kg·d) i.p.+HPE 200 mg/(kg·d) i.p. for 8 d. Following treatment, serum, liver, and kidney tissues were used to assess blood urea nitrogen (BUN), creatinine, enzymatic and non-enzymatic antioxidants, and lipid peroxidation. Gentamicin significantly increased serum BUN, creatinin, and liver and kidney levels of malondialdehyde (MDA). It also decreased the activity of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). Treatment with the HPE 100 mg/kg reversed gentamicin-induced alterations as evidenced by decreased serum BUN and creatinin, liver and kidney oxidant marker, and tubular necrosis as well as by an increase in antioxidant enzymes. It was found that HPE 200 mg/kg significantly increased liver and kidney tissue MDA levels in nephrotoxicity in rats. As a result, these findings support the proposition that HPE in 100 mg/kg dose demonstrates in the kidney and liver as free radicals and scavenger to prevent the toxic effects of gentamicin in both the biochemical and histopathology parameters.

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“…Therefore, if the bilirubin level is higher than normal, it may mean that the liver is not functioning correctly [15]. The amount of albumin in gentamicin treated rats showed a significant decrease compared to control group [16]. Serum bilirubin is considered an index for the assessment of hepatic function and any abnormal increase indicates hepatobiliary disease and severe disturbance of hepatocellular architecture [17].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

Aboubakr

Abdelazem

2015

IJBAS

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The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 & 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.

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Pathological Changes of Gentamicin in Liver Tissue and Antioxidant Property of Cinnamon Extract on Wistar Rats

Cited by 16 publications

References 17 publications

Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats

Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats

Effect of Helichrysum plicatum DC. subsp. plicatum ethanol extract on gentamicin-induced nephrotoxicity in rats

Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

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