Pathology findings with acrylic implants

Ruiz, David; Burkhardt, Karim; Jean, B.; Muster, Michel; Martin, Jean-Baptiste; Bouvier, J. F.; Fasel, J.; Rüfenacht, Daniel A.; Kurt, A

doi:10.1016/s8756-3282(99)00140-4

Cited by 139 publications

(77 citation statements)

References 12 publications

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“…Kaufmann et al (37) and Cotten et al (38) could not find a significant association between the amount of injected PMMA and the analgesic effect because even small cement volumes lead to partial or complete pain relief. Other hypotheses regarding the underlying mechanism include the destruction of nerve endings through the exothermic reaction of PMMA during polymerization and its additional cytotoxic effects (39). These results are in accordance with our observations because even patients with a small vertebral filling volume of 1-2 mL of PMMA (13 of 67 vertebrae; 19.4%) in the thoracic and lumbar spine have reported substantial pain relief.…”

Section: Discussionsupporting

confidence: 91%

CT fluoroscopy-guided percutaneous vertebroplasty in patients with multiple myeloma: analysis of technical results in 44 sessions with 67 vertebrae treated

Trumm

Jakobs²,

Pahl³

et al. 2011

Diagn Interv Radiol

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Section: Discussionsupporting

confidence: 91%

CT fluoroscopy-guided percutaneous vertebroplasty in patients with multiple myeloma: analysis of technical results in 44 sessions with 67 vertebrae treated

Trumm

Jakobs²,

Pahl³

et al. 2011

Diagn Interv Radiol

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“…The observed maximum temperatures seem to be adequate according to ISO and ASTM standards; however, several authors relate pain relief in PVP practiced on vertebral tumors, to the malignant tissue necrosis and the destruction of sensitive nerve endings by the heat released during the exothermic polymerization reaction and the toxicity of the acrylic monomer. 19 Although the setting parameters were only determined for cements prepared with untreated fillers, there are not firm reasons to expect a significant change of their values when silanated fillers are used.…”

Section: Setting Parametersmentioning

confidence: 99%

“…20 No significant differences (95.0% confidence level) were obtained among the different formulations. Some workers 19 have attributed the efficacy of PVP for pain relief in tumored vertebral bodies to, in part, the toxicity of monomer released, both in the first stage of injection and after curing.…”

Section: Residual Monomer Contentmentioning

confidence: 99%

Injectable acrylic bone cements for vertebroplasty with improved properties

2003

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Currently commercially available acrylic bone cements lack adequate radiopacity and viscosity when they are used in percutaneous vertebroplasty (PVP). In this work improved formulations of radiopaque and injectable poly(methyl methacrylate) bone cements were prepared with different amounts (10 -50 wt.%) of BaTiO 3 or SrTiO 3 particles as the radiopaque agent. Two sets of cements were prepared by using untreated or silanated radiopaque particles, respectively. The influence of the content and nature of the radiopaque agent as well as its silanation with 3-(trimethoxysilyl) propyl methacrylate (␥-MPS), on the curing parameters, residual monomer content, radiopacity, mechanical properties, and injectability of the resulting materials, was examined. Doughing and setting times, maximum temperature, and compressive strength of all formulations fulfilled the requirements of standard specifications, with values of peak temperature in the range 57-72°C and those of compressive strength between 114 and 135 MPa. Formulations containing at least 20 wt.% BaTiO 3 or SrTiO 3 had radiopacities equal to or greater than that corresponding to 2 mm of Al as required for surgical plastics. Injectability of any of the formulations provided 75-80 wt.% of the total mass manually injected through a conventional biopsy needle 4 min after mixing. Silanation of the BaTiO 3 or SrTiO 3 particles led to formulations with improved mechanical properties and injectability compared to those obtained with the untreated fillers.

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“…Moreover, the tactile feedback of the cement flow into the bone is reduced with the pressure device. Altering the recommended liquid to powder ratio may cause complications such as toxicity and reduced cement strength [12,27].…”

Section: A New Cannula To Ease Cement Injection During Vertebroplastymentioning

confidence: 99%