Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Ullah, Amin; Zhao, Jing; Singla, Rajeev K.; Shen, Bairong

doi:10.3389/fcell.2023.1272536

Cited by 5 publications

(1 citation statement)

References 218 publications

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“…We detected a decrease in placental eotaxin-1 when animals were treated for six days with either SHS (1.8-fold, p < 0.003) or eCigs (1.6-fold, p < 0.008, Figure 5 B). KC (keratinocyte-derived chemokine; also known as chemokine (C-X-C motif) ligand 1 or CXCL1) is a chemokine known to aid the process of trophoblast invasion [ 46 ]. Similar to our findings on eotaxin-1 production, we observed KC production to be decreased when the animals were treated with SHS (1.7-fold, p < 0.0002) or eCigs (1.3-fold, p < 0.02) for six days ( Figure 5 C).…”

Section: Resultsmentioning

confidence: 99%

Different Lengths of Gestational Exposure to Secondhand Smoke or e-Cigarette Vapor Induce the Development of Placental Disease Symptoms

Kirkham,

Cooper,

Broberg

et al. 2024

Cells

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Exposure to cigarette smoke is known to induce disease during pregnancy. Recent evidence showed that exposure to secondhand smoke (SHS) negatively impacts fetal and placental weights, leading to the development of intrauterine growth restriction (IUGR). Electronic cigarettes (eCigs) represent a phenomenon that has recently emerged, and their use is also steadily rising. Even so, the effects of SHS or eCigs during gestation remain limited. In the present study, we wanted to characterize the effects of SHS or eCig exposure at two different important gestational points during mouse pregnancy. C57/Bl6 mice were exposed to SHS or eCigs via a nose-only delivery system for 4 days (from 14.5 to 17.5 gestational days (dGA) or for 6 days (from 12.5 dGA to 17.5 dGA)). At the time of necropsy (18.5 dGA), placental and fetal weights were recorded, maternal blood pressure was determined, and a dipstick test to measure proteinuria was performed. Placental tissues were collected, and inflammatory molecules in the placenta were identified. Treatment with SHS showed the following: (1) a significant decrease in placental and fetal weights following four days of exposure, (2) higher systolic and diastolic blood pressure following six days of exposure, and (3) increased proteinuria after six days of exposure. Treatment with eCigs showed the following: (1) a significant decrease in placental weight and fetal weight following four or six days of exposure, (2) higher systolic and diastolic blood pressure following six days of exposure, and (3) increased proteinuria after six days of exposure. We also observed different inflammatory markers associated with the development of IUGR or PE. We conclude that the detrimental effects of SHS or eCig treatment coincide with the length of maternal exposure. These results could be beneficial in understanding the long-term effects of SHS or eCig exposure in the development of placental diseases.

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Section: Resultsmentioning

confidence: 99%

Different Lengths of Gestational Exposure to Secondhand Smoke or e-Cigarette Vapor Induce the Development of Placental Disease Symptoms

Kirkham,

Cooper,

Broberg

et al. 2024

Cells

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CX3CL1 (Fractalkine): An important cytokine in physiological and pathological pregnancies

Hu,

Huang,

Yin

et al. 2024

Journal of Reproductive Immunology

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Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia

Li,

Chen,

Zhang

et al. 2024

Reprod Biol Endocrinol

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Background Preeclampsia (PE) is a multifaceted pregnancy syndrome marked by multiple system involvement and a significant contributor to maternal mortality. This condition is characterized by a critical lack of early diagnostic measures and viable therapeutic options, underscoring an urgent need for the identification of reliable markers with both diagnostic and therapeutic potential. Methods This study utilized Weighted Gene Co-expression Network Analysis (WGCNA) to explore the role of G protein-coupled receptors (GPCRs) in the pathogenesis of PE. Results Our analysis pinpointed CCBP2 (ACKR2) and GPR87 as central PE-associated GPCRs. Experimental validation of these findings revealed that both CCBP2 and GPR87 significantly inhibit the proliferation, migration, and invasion of trophoblast cells—core phenomena underlying the pathology of PE. Conclusion Thus, our findings add valuable candidates to the growing list of biomarkers for preeclampsia and offer promising targets for future therapeutic development. Supplementary Information The online version contains supplementary material available at 10.1186/s12958-024-01324-5.

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Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Cited by 5 publications

References 218 publications

Different Lengths of Gestational Exposure to Secondhand Smoke or e-Cigarette Vapor Induce the Development of Placental Disease Symptoms

Different Lengths of Gestational Exposure to Secondhand Smoke or e-Cigarette Vapor Induce the Development of Placental Disease Symptoms

CX3CL1 (Fractalkine): An important cytokine in physiological and pathological pregnancies

Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia

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