Pathophysiology, Diagnosis, Treatment, and Genetics of Carpal Tunnel Syndrome: A Review

Malakootian, Mahshid; Soveizi, Mahdieh; Gholipour, Akram; Oveisee, Maziar

doi:10.1007/s10571-022-01297-2

Cited by 16 publications

(12 citation statements)

References 109 publications

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“…A wrist fracture can narrow the carpal tunnel and irritate the median nerve, as can the swelling and inflammation caused by rheumatoid arthritis. Additionally, people who have smaller carpal tunnels or who have a bone arrangement that impinges on the carpal tunnel may be more susceptible to developing CTS [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Perceived stress, coping strategies, symptoms severity and function status among carpal tunnel syndrome patients: a nurse-led correlational Study

Asal,

Atta,

Abdelaliem

et al. 2024

BMC Nurs

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Background Carpal tunnel syndrome (CTS) is a prevalent condition characterized by hand pain, tingling, and numbness. The severity of symptoms and functional status in CTS patients may be influenced by perceived stress and how individuals cope with it. However, scarce knowledge exists about the role of coping strategies as moderators in this relationship. Unfolding the role of perceived stress and coping strategies for CTS management will help the nurse to provide comprehensive and tailored nursing care. This will ultimately improve patient comfort, functionality, and quality of life. Purposes This study aimed to examine the role of coping strategies (adaptive and maladaptive) in the relationship between perceived stress and both symptoms severity and function status among those patients. Method We employed a multisite, correlational study design with moderation analysis. The study included 215 patients with CTS from neurosurgery outpatient clinics at three hospitals in Egypt. After obtaining their consent to participate, eligible participants completed anonymous, self-reported measures of perceived stress, the brief COPE inventory, and the Boston Carpal Tunnel Questionnaire. Demographic and biomedical data were also collected. The questionnaire took about 20 min to be completed. The data was collected over six months, starting in February 2023. Results The results showed that perceived stress, adaptive coping, and maladaptive coping were significant predictors of symptoms severity and functional status. Adaptive coping moderated the relationships between perceived stress and both symptoms severity and function status, while maladaptive coping did not. The interaction between perceived stress and adaptive coping explained a moderate effect on symptoms severity and function status after controlling for the main effects and the covariates. Conclusion This study explored the relationship between perceived stress, coping strategies, and outcomes in patients with CTS. The results indicate that nurses play a vital role in assessing and assisting patients to adopt effective coping strategies to manage perceived stress and alleviate symptoms and functional impairment. Moreover, the findings support the need for psychological interventions that address both perceived stress and coping strategies as a way to enhance the functioning status and quality of life of patients with CTS.

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Section: Introductionmentioning

confidence: 99%

Perceived stress, coping strategies, symptoms severity and function status among carpal tunnel syndrome patients: a nurse-led correlational Study

Asal,

Atta,

Abdelaliem

et al. 2024

BMC Nurs

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“…Initially, modifications to daily habits, including the avoidance of heavy work-related activities and the adoption of appropriate biomechanical postures, should be considered as a first-line approach. This may involve the use of braces or splints at night, physiotherapy with exercises aimed at tendon and nerve gliding, low-power laser therapy, and local corticosteroid injections [15]. While conservative therapy can provide short-term relief for patients on pain and functional scales, its long-term effectiveness is still the subject of debate [16].…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Ultrasound-Guided Perineural Hydrodissection as a Minimally Invasive Treatment in Carpal Tunnel Syndrome: A Systematic Review

Sveva,

Farì,

Fai

et al. 2024

JPM

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Ultrasound-guided perineural hydrodissection (HD) is a novel technique that has been found to be effective in providing mechanical release of perineural adhesions and decompression of the nerve, reducing inflammation and edema and restoring its physiological function. It has a significant impact on chronic neuropathic pain (20 ± 4 weeks with VAS < 5 or VAS diminished by 2 points after the procedure). Carpal tunnel syndrome (CTS) is a common entrapment mononeuropathy, and its distribution is typically innervated by the median nerve. Patients with mild or moderate CTS may benefit from nonsurgical treatments or conservative therapies. This review was conducted following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement guidelines. Four investigators assessed each title, abstract, and full-text article for eligibility, with disagreements being resolved by consensus with two experienced investigators. The qualitative assessment of the studies was carried out using the modified Oxford quality scoring system, also known as the modified Jadad score. Furthermore, risk of possible biases was assessed using the Cochrane collaboration tool. The results of this review suggest that US-guided HD is an innovative, effective, well-tolerated, and safe technique (11 out of 923 patients had collateral or side effects after the procedure). However, further studies comparing all drugs and with a larger sample population are required to determine the most effective substance.

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“…The first symptom in most patients is the nocturnal numbness of the fingers. With the advancement of the disease, the patient may complain of thenar muscle atrophy, limited opposition of the thumb, sleep disturbances, shortness of the daily activities and psychiatric disorders in severe cases [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

“…Figure[4]: A mini incision was placed in the radial border of the ring finger line; it begins 1 cm to the distal flexor wrist crease…”

mentioning

confidence: 99%

A Clinical Outcome of Median Nerve Neurolysis For the Treatment of Carpal Tunnel Syndrome: Conventional S-Shaped Versus Transwrist Mini-Incision Techniques

Abd-Elghany

2023

International Journal of Medical Arts

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Article informationBackground: Carpal Tunnel Syndrome [CTS] is the commonest entrapment syndrome of peripheral nerves. Many surgical approaches are in use for median nerve release. However, there is no consensus on the optimal approach. The aim of the work:The current work aimed to evaluate the outcome of two surgical approaches: the open longitudinal mini-incision and conventional approach.Methods: This was a retrospective study compared conventional to mini-incision approach for CTS treatment. Ninety patients were included, 45 in each group. The collected data included general patient characteristics, median nerve conduction electrophysiological study, operative and postoperative data.The final assessment at the end of the third postoperative month.Results: Patient's age ranged between 30 and 65 years, and females were predominant in both groups. there were no significant differences between conventional and mini-incision groups regarding patient characteristics, operable side, clinical signs, duration of symptoms, preoperative pain scores, functional scores and electrophysiological results. However, the operative time and incision length were significantly shorter among mini-incision than conventional group [19.02 ± 1.60 vs. 22.53 ± 3.62 minutes and 14.44 ± 2.34 vs. 33.49 ± 3.28 mm]. Patients experiencing surgical wound pain were significantly lower among mini-incision than conventional group [6.7% vs. 24.4%], and pain scores were significantly lower among patients in mini-incision group. Conclusion:The open mini-incision surgical approach for treatment of CTS is as effective as the conventional approach and it had advantages over it [mainly, shorter operative time and better aesthetic results].

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Pathophysiology, Diagnosis, Treatment, and Genetics of Carpal Tunnel Syndrome: A Review

Cited by 16 publications

References 109 publications

Perceived stress, coping strategies, symptoms severity and function status among carpal tunnel syndrome patients: a nurse-led correlational Study

Perceived stress, coping strategies, symptoms severity and function status among carpal tunnel syndrome patients: a nurse-led correlational Study

Safety and Efficacy of Ultrasound-Guided Perineural Hydrodissection as a Minimally Invasive Treatment in Carpal Tunnel Syndrome: A Systematic Review

A Clinical Outcome of Median Nerve Neurolysis For the Treatment of Carpal Tunnel Syndrome: Conventional S-Shaped Versus Transwrist Mini-Incision Techniques

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