“…Strategies to improve adherence to inhalation therapy among patients (e.g. patient instruction and education) have been shown to work among patients with asthma (Put et al, 2003;Onyirimba et al, 2003), whereas, in COPD patients, these strategies were less successful (Rand, 2005;Restrepo, et al, 2008). Therefore, non-adherence remains an unresolved problem despite decades of research, and is a factor resulting in suboptimal clinical outcomes and poor disease control.…”