Patient Centered Outcomes among a Cohort Receiving Regenerative Endodontic Procedures or Apexification Treatments

Casey, Sharon M.; Fox, Dani; Duong, Wilson; Bui, Nghia; Latifi, Naghmeh; Ramesh, Veena; Podborits, Eugene; Flake, Natasha M.; Khan, Asma; Gibbs, Jennifer L.

doi:10.1016/j.joen.2021.11.013

Cited by 18 publications

(16 citation statements)

References 30 publications

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“…Eighteen articles [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] evaluated the clinical outcome of regenerative endodontic procedures (REP) and five articles [34][35][36][37][38] on the apexification procedure. Only nine articles [39][40][41][42][43][44][45][46][47] evaluated and compared the clinical outcome between regeneration and apexification procedure. MTA coronal barrier was sealed with a thin GI base, and final coronal restorations were placed at the same visit using acid etch composite resin.…”

Section: Designmentioning

confidence: 99%

“…Nine articles [39][40][41][42][43][44][45][46][47] compared the outcome between regeneration and apexification procedure, of which two articles [39,40] were RCTs, and seven articles [41][42][43][44][45][46][47] were NRCTs. In the RCTs, a total of 133 participants and 133 teeth were included.…”

Section: Participantsmentioning

confidence: 99%

“…Among fourteen NRCTs, four studies [29][30][31][32] investigated clinical outcome of the revascularization procedure, three studies [36,38] were on apexification and seven studies [41][42][43][44][45][46][47] compared regeneration versus apexification…”

Section: Interventionmentioning

confidence: 99%

“…In apexification NRCTs, one study [37] was assessed to be at moderate risk of bias and two studies [36,38] were assessed to be at serious risk. In regeneration versus apexification NRCTs, one study [47] was assessed to be a low risk of bias, five studies [42][43][44][45][46] were assessed to be a moderate risk, and one study [41] was at serious risk.…”

Section: Analysis Of Quality Of the Studiesmentioning

confidence: 99%

“…The success rate between both groups was found not to be statistically significantly different. Five studies [39,41,42,45,46] were pooled to assess the survival rate. The procedures showed no significant difference with RR 1.01, at 95% CI [0.97, 1.06], p = 0.55 (Figure 9).…”

Section: Success Rate Of Rep With Apc Compared To Bc In Young Immatur...mentioning

confidence: 99%

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Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis

Panda

Mishra

Govind

et al. 2022

JCM

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This systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews), bearing the registration number CRD42021230284. A bibliographic search in the biomedical databases was conducted in four databases—PubMed, CENTRAL, EMBASE and ProQuest—using searching keywords and was limited to studies published between January 2000 and April 2022 in English. The search was supplemented by manual searching, citation screening and scanning of all reference lists of selected paper. The study selection criteria were randomized clinical trial, prospective clinical studies and observational studies. The search found 32 eligible articles, which were included in the study. The quality assessment of the studies was performed using the Cochrane risk of bias tool for randomized control trials and non-randomized clinical studies. The meta-analysis was performed using Review Manager software (REVMAN, version 5). The results indicated that a clinicians’ MTA apexification procedure was more successful compared to calcium hydroxide. In RET, apical closure and overall success rate is statistically same for both apical platelet concentrates (APCs) and blood clots (BC). Both interventions have similar survival rates; however, RET should be preferred in cases where the root development is severely deficient, there is insufficient dentine and the tooth’s prognosis is hopeless even with an apexification procedure.

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