Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele

Danzer, Enrico; Gerdes, Marsha; D’Agostino, Jo Ann; Bernbaum, Judy; Hoffman, Casey; Rintoul, Natalie E.; Herkert, Lisa M.; Flake, Alan W.; Adzick, N. Scott; Hedrick, Holly L.

doi:10.1016/j.earlhumdev.2014.12.009

Cited by 33 publications

(17 citation statements)

References 23 publications

(35 reference statements)

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“…A previous study reported both mental and motor developmental delay in more than half of 31 children with giant omphalocele aged 6–35 months 6. We suspect the higher proportion of mental developmental delay could be explained by the inclusion of children with major MCA and rare syndromes in that study 6…”

Section: Discussionmentioning

confidence: 73%

Omphalocele: from diagnosis to growth and development at 2 years of age

Hijkoop

Peters

Lechner

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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Section: Discussionmentioning

confidence: 73%

Omphalocele: from diagnosis to growth and development at 2 years of age

Hijkoop

Peters

Lechner

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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“…Special attention has been focused on the neurodevelopmental outcome of patients with omphalocele. A recent study has shown neurological impairments in more than half of giant omphalocele survivors [57].…”

Section: Treatment Outcomementioning

confidence: 99%

Major abdominal wall defects in the low- and middle-income setting: current status and priorities

2020

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Major congenital abdominal wall defects (gastroschisis and omphalocele) may account for up to 21% of emergency neonatal interventions in low-and middle-income countries. In many low-and middle-income countries, the reported mortality of these malformations is 30-100%, while in high-income countries, mortality in infants with major abdominal wall reaches less than 5%. This review highlights the challenges faced in the management of newborns with major congenital abdominal wall defects in the resource-limited setting. Current high-income country best practice is assessed and opportunities for appropriate priority setting and collaborations to improve outcomes are discussed.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…55 Autism, associated with delays in cognitive and language outcomes, was suspected/confirmed in 13% of the patients. Hypotonicity was found in 55% of survivors and was, together with delayed stage closure and older age at final repair, associated with motor dysfunction.…”

Section: Resultsmentioning

confidence: 99%

Giant omphalocele: current perspectives

Mack¹,

Rogdo²

2016

RRN

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Giant omphalocele (GO) is a congenital ventral abdominal wall defect characterized by a large opening with herniated abdominal organs, including liver, loss of abdominal cavity volume, and other associated congenital anomalies. Treatment of patients with GO represents a major challenge for involved caregivers. Despite significant improvements in neonatal intensive and surgical care over the last decades, the condition is still associated with high mortality rates and a high risk of severe morbidity in survivors. The principles of the earliest attempts to treat GO surgically and conservatively are still easily recognized in the main approaches used today. In this review, we discuss the more recent developments in the treatment of GO, including perioperative management and associated morbidities of the condition.

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Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele

Cited by 33 publications

References 23 publications

Omphalocele: from diagnosis to growth and development at 2 years of age

Omphalocele: from diagnosis to growth and development at 2 years of age

Major abdominal wall defects in the low- and middle-income setting: current status and priorities

Giant omphalocele: current perspectives

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