Although cloud-based healthcare services are booming, in-depth research has not yet been conducted in this field. This study aims to address the shortcomings of previous research by analyzing all journal articles from the last five years using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) systematic literature review methodology. The findings of this study highlight the benefits of cloud-based healthcare services for healthcare providers and patients, including enhanced healthcare services, data security, privacy issues, and innovative information technology (IT) service delivery models. However, this study also identifies challenges associated with using cloud services in healthcare, such as security and privacy concerns, and proposes solutions to address these issues. This study concludes by discussing future research directions and the need for a complete solution that addresses the conflicting requirements of the security, privacy, efficiency, and scalability of cloud technologies in healthcare.