Patient Selection for Protected Percutaneous Coronary Intervention

Kim, Seung Hyun; Baumann, Stefan; Behnes, Michael; Borggrefe, Martin; Akın, İbrahim

doi:10.1016/j.ccl.2020.06.004

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Percutaneous coronary intervention (PCI) with growing development is an efficient treatment for complex coronary artery disease 1 . PCI helps in reducing myocardial infarction and death in patients with acute coronary syndromes 2 .…”

Section: Introductionmentioning

confidence: 99%

The potential function of SP1 and CPPED1 in restenosis after percutaneous coronary intervention

Wang

Liang

Cai

et al. 2022

Journal of Cardiac Surgery

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Objectives Impacts of molecular pathways have been discussed recently on restenosis after percutaneous coronary intervention (PCI). Hence, this study aimed to explore the impact of calcineurin‐like phosphoesterase domain containing 1 (CPPED1) and specificity protein 1 (SP1) on restenosis after PCI. Methods A carotid balloon injury rat model was established, followed by western blot analysis of SP1 and CPPED1 expression in carotid artery (CA) tissues. After SP1 and CPPED1 were overexpressed, the neointimal hyperplasia and luminal stenosis were assessed. In addition, EPC underwent hypoxia/reoxygenation (H/R) treatment to construct an endothelial injury cell model. Then, cell proliferation, apoptosis, intracellular reactive oxygen species (ROS), and Ca2+ concentration were detected with cell counting kit‐8 (CCK‐8), flow cytometry, Chloromethyl‐2'7'‐dichlorofluorescein diacetate (CM‐H2DCFDA) penetrant, and Fluo‐4 AM staining, respectively. The binding relationship between SP1 and CPPED1 was verified by dual‐luciferase reporter and chromatin immunoprecipitation (ChIP) assays. Results SP1 and CPPED1 were lowly expressed in the model rats with carotid balloon injury. Mechanistically, SP1 bound to the promoter region of CPPED1 to activate CPPED1 expression. Overexpressing SP1 or CPPED1 lowered neointimal formation and restenosis rate, thus promoting the recovery of carotid balloon injury in rats. Meanwhile, SP1 and CPPED1 upregulation reduced ROS levels, Ca2+ concentration, and apoptosis of EPCs, accompanied by accelerated EPC viability. Conclusions SP1 or CPPED1 overexpression reduced neointimal formation and restenosis rate in carotid balloon injury.

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Section: Introductionmentioning

confidence: 99%

The potential function of SP1 and CPPED1 in restenosis after percutaneous coronary intervention

Wang

Liang

Cai

et al. 2022

Journal of Cardiac Surgery

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“…Coronary artery disease has ranked high among the leading causes of death and disability in the worldwide, posing a serious threat to the health of the population 1 , 2 . With continuous improvement of the equipment and optimization of procedures, percutaneous coronary stent intervention (PCI) has become safer and easier to operate than before, and it is regarded as one of the most effective methods to improve myocardial perfusion and alleviate clinical symptoms 3 . However, a major clinical problem is postoperative stent thrombosis, which can lead to in-stent restenosis (ISR), bringing many risks such as potential recurrent cardiovascular adverse events, seriously affecting the long-term prognosis of patients 4 .…”

Section: Introductionmentioning

confidence: 99%

Exploring the best monochromatic energy level in dual energy spectral imaging for coronary stents after percutaneous coronary intervention

Liu

Wang

et al. 2021

Sci Rep

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In this study, the optimal monochromatic energy level in dual-energy spectral CT required for imaging coronary stents after percutaneous coronary intervention (PCI) was explored. Thirty-five consecutive patients after PCI were examined using the dual-energy spectral CT imaging mode. The original images were reconstructed at 40–140 keV (10-keV interval) monochromatic levels. The in-stent and out-stent CT values at each monochromatic level were measured to calculate the signal-to-noise ratio(SNR) and contrast-to-noise ratio (CNR) for the vessel and the CT value difference between the in-stent and out-stent lumen (dCT (in–out)), which reflects the artificial CT number increase due to the beam hardening effect caused by the stents. The subjective image quality of the stent and in-stent vessel was evaluated by two radiologists using a 5-point scale. With the increase in energy level, the CT value, SNR, CNR, and dCT (in–out) all decreased. At 80 keV, the mean CT value in-stent reached (345.24 ± 93.43) HU and dCT (in–out) started plateauing. In addition, the subjective image quality of the stents and vessels peaked at 80 keV. The 80 keV monochromatic images are optimal for imaging cardiac patients with stents after PCI, balancing the enhancement and SNR and CNR in the vessels while minimizing the beam hardening artifacts caused by the stents.

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