2022
DOI: 10.3389/fonc.2022.966134
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Patient selection, inter-fraction plan robustness and reduction of toxicity risk with deep inspiration breath hold in intensity-modulated radiotherapy of locally advanced non-small cell lung cancer

Abstract: BackgroundState-of-the-art radiotherapy of locally advanced non-small cell lung cancer (LA-NSCLC) is performed with intensity-modulation during free breathing (FB). Previous studies have found encouraging geometric reproducibility and patient compliance of deep inspiration breath hold (DIBH) radiotherapy for LA-NSCLC patients. However, dosimetric comparisons of DIBH with FB are sparse, and DIBH is not routinely used for this patient group. The objective of this simulation study was therefore to compare DIBH an… Show more

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Cited by 5 publications
(2 citation statements)
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“…For example, during the implementation of chest radiation therapy, deep inspiration breath hold (DIBH) has been shown to have dosimetric advantages in terms of reducing excessive lung exposure and lung risk factors. This method can also reduce cardiac exposure, although, at the same time, it incurs additional costs and is difficult to implement for the patients (43,44). Due to the lack of such equipment at our radiation therapy center, this technology could not be used.…”
Section: A Left P-values Of Subgroup Comparisons a Dosimetric -------...mentioning
confidence: 99%
“…For example, during the implementation of chest radiation therapy, deep inspiration breath hold (DIBH) has been shown to have dosimetric advantages in terms of reducing excessive lung exposure and lung risk factors. This method can also reduce cardiac exposure, although, at the same time, it incurs additional costs and is difficult to implement for the patients (43,44). Due to the lack of such equipment at our radiation therapy center, this technology could not be used.…”
Section: A Left P-values Of Subgroup Comparisons a Dosimetric -------...mentioning
confidence: 99%
“…The use of DIBH treatment for lung lesions can reduce the total irradiated lung volume and dose to near OARs with respect to free breathing (FB) treatment (19)(20)(21) and can be successfully customized for the different clinical scenarios.…”
Section: Introductionmentioning
confidence: 99%