“…The second-generation cryoballoon (CB) (Arctic FrontTM, Medtronic Inc, Minneapolis, MN), released in 2012, achieved more uniform cooling across the entire distal hemisphere of the balloon using 8 instead of 4 injection tubes [ 4 , 5 ] considerably improving the acute results of PVI as well as the long-term efficacy in diverse clinical settings [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Nowadays, the CB constitutes an established alternative to radio frequency (RF) ablation for PVI [ 1 , 15 ], which offers the possibility to isolate the PVs with a single application.…”