2018
DOI: 10.1186/s12987-018-0115-4
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Patient-specific cranio-spinal compliance distribution using lumped-parameter model: its relation with ICP over a wide age range

Abstract: BackgroundThe distribution of cranio-spinal compliance (CSC) in the brain and spinal cord is a fundamental question, as it would determine the overall role of the compartments in modulating ICP in healthy and diseased states. Invasive methods for measurement of CSC using infusion-based techniques provide overall CSC estimate, but not the individual sub-compartmental contribution. Additionally, the outcome of the infusion-based method depends on the infusion site and dynamics. This article presents a method to … Show more

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Cited by 12 publications
(25 citation statements)
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References 29 publications
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“…Total cerebral blood flow is an intermediate parameter derived during the calculation of MR‐ICP. Total cerebral blood flow significantly decreases with age, as also seen in our study subjects. The mean cerebral blood flow in a brain trauma cohort was on average lower than that reported in the literature in healthy subjects of similar age (776 ± 107 mL/min), which may be in part due to loss of autoregulation in the brain trauma cohort.…”
Section: Discussionsupporting
confidence: 90%
See 2 more Smart Citations
“…Total cerebral blood flow is an intermediate parameter derived during the calculation of MR‐ICP. Total cerebral blood flow significantly decreases with age, as also seen in our study subjects. The mean cerebral blood flow in a brain trauma cohort was on average lower than that reported in the literature in healthy subjects of similar age (776 ± 107 mL/min), which may be in part due to loss of autoregulation in the brain trauma cohort.…”
Section: Discussionsupporting
confidence: 90%
“…2 The derivation of relative contributions of cranium and spinal canal to the overall craniospinal mechanical compliance is also described previously. 21 Briefly, the same phase-contrast scans used to derive the MR-ICP value are used in the lumped-parameter electrical model that imitates the hemo-and hydrodynamics in the craniospinal system. The net transcranial blood flow is regarded as the input to the model that drives the output craniospinal CSF waveform.…”
Section: Mr-icp and Craniospinal Compliance Distributionmentioning
confidence: 99%
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“…For example, as part of a clinical trial, the intracranial CSF dynamic profile was studied by infusion in NPH patients and found to differ from that of healthy controls [111]. Recently, an MRI study on healthy individuals by Burman et al [112] determined the relative distribution of compliance between the spinal and cranial CSF compartments and proposed a model that can be used to estimate both the cranial compliance and intracranial pressure non-invasively. Hence, non-invasive MRI techniques continue to be a promising route to aid diagnosis and determine shunt surgery response.…”
Section: Disease Statesmentioning
confidence: 99%
“…It is important to gain more knowledge about the intracranial pressure dynamics in pediatric TBI when BCT is used. Children have several anatomical and physiological differences compared with adults [ 11 , 13 ], e.g., regarding optimal cerebral perfusion pressure (CPP) levels, cerebrovascular pressure reactivity, and intracranial compliance [ 2 , 3 , 12 , 18 , 28 ]. Intracranial compliance is the ability to compensate for increases in intracranial volume, i.e., cerebrospinal compensatory reserve.…”
Section: Introductionmentioning
confidence: 99%