Patient-specific evolution of renal function in chronic heart failure patients dynamically predicts clinical outcome in the Bio-SHiFT study

Branković, Miloš; Akkerhuis, K. Martijn; Boven, Nick van; Anroedh, Sharda S.; Constantinescu, Alina A.; Çalışkan, Kadir; Manintveld, Olivier C.; Cornel, Jan H.; Baart, Sara J.; Rizopoulos, Dimitris; Hillege, Hans L.; Boersma, Eric; Umans, Victor; Kardys, Isabella

doi:10.1016/j.kint.2017.09.013

Cited by 36 publications

(42 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Serial Biomarker Measurements and New Echocardiographic Techniques in Chronic Heart Failure Patients Result in Tailored Prediction of Prognosis (Bio-SHiFT) is a prospective cohort of stable patients with CHF, conducted in Erasmus MC, Rotterdam, and Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands [22,23]. Patients were included if aged ≥18 years, capable of understanding and signing informed consent, and if CHF had been diagnosed ≥3 months ago according to European Society of Cardiology guidelines (Fig.…”

Section: Chf Cohortmentioning

confidence: 99%

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure

Branković

Akkerhuis

Mouthaan

et al. 2019

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Section: Chf Cohortmentioning

confidence: 99%

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure

Branković

Akkerhuis

Mouthaan

et al. 2019

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

“…30 In this study, the definition of CKD was based on sCr levels; however, taking into account that sCr does not increase until the eGFR has moderately decreased, this study may not have detected all cases of kidney damage. 30 These circumstances mean that sCr is less reliable for making therapeutic decisions specifically in patients with severe MR and heart failure; [11][12][13][14] consequently, it did not adequately predict all-cause mortality within 12 months after PMVR in the present study.…”

Section: Discussionmentioning

confidence: 73%

“…11 Assessment of renal function, however, is complicated by a diagnostic deficiency of serum creatinine (sCr), the diagnostic gold standard used in routine clinical practice. [11][12][13][14] Two other biomarkers have been recently validated as specific indicators of acute or chronic renal failure and predictors of poor outcome. 13,15,16 Cystatin C, a cysteine protease inhibitor, has been identified as a specific and sensitive biomarker of renal function [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cystatin C and neutrophil gelatinase‐associated lipocalin as predictors of mortality in patients undergoing percutaneous mitral valve repair (MitraClip)

Dörr

Walther

Liebetrau

et al. 2018

Clinical Cardiology

View full text Add to dashboard Cite

Background Compromised renal function is a major risk factor that is strongly associated with poor outcome in patients with mitral regurgitation (MR) and heart failure. Cystatin C, a cysteine protease inhibitor, has been used as a specific and sensitive biomarker of renal function. Neutrophil gelatinase‐associated lipocalin (NGAL) is another sensitive biomarker that specifically indicates functional and structural kidney damage. The aim of the present study was to determine the predictive value of serum cystatin C and urinary NGAL as indicators of mortality in patients undergoing percutaneous mitral valve repair (PMVR). Methods A total of 120 consecutive patients (age: 77.3 years [±11.2]) undergoing PMVR using the MitraClip system were included in this study. Venous blood and urinary samples were collected for biomarker analysis prior to PMVR. Physiological parameters, medication use, safety events, and all‐cause mortality were assessed 12 months after the procedure. Results Twelve months after PMVR, there was a significant reduction in the severity of MR (P < 0.001), and an improvement in the New York Heart Association class (P < 0.01) was documented. Baseline levels of serum cystatin C (nonsurvivors: 2.4 mg/L [interquartile, IQR: 1.7;3.1] vs survivors: 1.7 mg/L [IQR: 1,3;2.1], P < 0.001) and urinary NGAL (nonsurvivors: 242.0 ng/mL [IQR: 154.5;281.5] vs survivors: 132.0 ng/mL [IQR:107.0;177.3], P < 0.001) were significantly higher in patients who died during the 12‐month follow‐up period. Conclusion Cystatin C and urinary NGAL were found to be predictors of long‐term mortality in high‐risk patients undergoing PMVR. Thus, cystatin C and NGAL assessment may be helpful in risk stratification in patients undergoing PMVR.

show abstract

“…Значительная часть их приходится на хроническую болезнь почек (ХБП). Среди пациентов с ХСН частота ХБП составляет от 9,2% при врожденных пороках сердца до 71,2% при ишемической этиологии ХСН [2].…”

Section: Remodeling Of the Heart And Vessels In Atrial Fibrillation Punclassified

Remodeling of the Heart and Vessels in Atrial Fibrillation Patients With Chronic Heart Failure According to Cystatin C-Related Glomerular Filtration Rate

Mironova¹,

Полянская²,

Суровцева³

2018

Russ J Cardiol

View full text Add to dashboard Cite

Цель. Изучить структурно-функциональные особенности левых отделов сердца и артерий у больных с постоянной формой фибрилляции предсердий (ФП) в сочетании с хроническая сердечная недостаточность (ХСН) ишемической этиологии в зависимости от цистатин С-обусловленной скоростью клубочковой фильтрации (СКФ). Материал и методы. 60 пациентов в возрасте от 35 до 60 лет с постоянной формой ФП ишемической этиологии. Всем пациентам были выполнены эхокардиография с верификацией дисфункции: систолическая функция оценивалась по фракции выброса левого желудочка по методу Simpson, для оценки диастолической дисфункции производилось определение скоростных характеристик трансмитрального кровотока и тканевой визуализации движения фиброзного кольца митрального клапана; суточное монито-рирование ЭКГ, объемная сфигмоплетизмография периферических артерий, оценка почечной функции с использованием формулы Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) по креатинину и цистатину С, оценка статуса коллагенообразования по уровню тканевого ингибитора матриксных металлопротеиназ 1 типа (TIMP-1) определение N-терминального фрагмента мозгового натрийуретического гормона (NT-proBNP). В первой части исследования пациенты были разделены на три группы -по уровню СКФ <30 мл/мин/1,73 м 2 , 30-60 мл/мин/1,73 м 2 и >60 мл/мин/1,73 м 2 . Во второй -по уровню цистатина С ниже и выше референсного значения. Результаты. У больных постоянной формой ФП и ХСН ишемической этиологии концентрация цистатина С в крови имеет прямые сильной степени зависимости взаимосвязи с NT-proBNP (r=0,60; р=0,003), индекс массы миокарда левого желудочка (r=0,68; р=0,005), E/e' среднее (r=0,73; p<0,001), время изоволюмического расслабления (r=0,53; р=0,012), cреднесуточной частоты сердечных сокращений (r=0,51; р=0,016), низкой степени зависимости -с TIMP-1 (r=0,26, p=0,002), обратные сильной степени зависимости -с SDNN (r=-0,59; р<0,001). СКФ (CKD-EPIcys) имеет обратные сильной степени зависимости взаимосвязи с septal e' (r=-0,51 р=0,041), c R-AI (r=-0,74; p<0,001), c CAVI1 (r=-0,53; р=0,008), и прямые средней степени зависимости -с SDNN (r=0,42; р<0,001). Заключение. Определение концентрация цистатина С в крови и цистатин С-зависимой СКФ у больных постоянной формой ФП и ХСН ишемической этиологии являются не только ранними маркерами ХБП, но и факторами риска развития и прогрессирования поражения органов-мишеней (сердца, сосудов). REMODELING OF THE HEART AND VESSELS IN ATRIAL FIBRILLATION PATIENTS WITH CHRONIC HEART FAILURE ACCORDING TO CYSTATIN C-RELATED GLOMERULAR FILTRATION RATEMironova S. V., Polyanskaya E. A., Surovtseva M. V.Aim. To investigate on structural and functional specifics of the left cardiac chambers and arteries in patients with permanent atrial fibrillation (AF) comorbid with chronic heart failure (CHF) of ischemic origin, with relation to cystatin C-dependent glomerular filtration rate (GFR). Material and methods. Sixty patients, age 35-60 y. o., with permanent AF of ischemic origin. All patients underwent echocardiography for the dysfunction verifica...

show abstract

Patient-specific evolution of renal function in chronic heart failure patients dynamically predicts clinical outcome in the Bio-SHiFT study

Cited by 36 publications

References 23 publications

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure

Evaluation of cystatin C and neutrophil gelatinase‐associated lipocalin as predictors of mortality in patients undergoing percutaneous mitral valve repair (MitraClip)

Remodeling of the Heart and Vessels in Atrial Fibrillation Patients With Chronic Heart Failure According to Cystatin C-Related Glomerular Filtration Rate

Contact Info

Product

Resources

About