Objective: To explore the application effect of multi-dimensional nursing combined with the Global Registry of Acute Events (GRACE) scoring system in the nursing of patients with atrial fibrillation after radiofrequency ablation with green precision catheter radiofrequency ablation. Methods: A total of 274 patients diagnosed with atrial fibrillation undergoing green precision catheter radiofrequency ablation were collected from the Department of Cardiology at our hospital in a retrospective study. After the inclusion, exclusion, diagnostic criteria and physical examination, all the subjects underwent green precision catheter radiofrequency ablation. According to various nursing methods that were adopted, they were divided into two groups with 7–14 days of nursing intervention by digital randomization: the study group (multi-dimensional nursing combined with GRACE scoring system evaluation, n = 136 cases) and the control group (postoperative routine nursing, n = 138 cases). The MOS item short from health survey (SF-36) score, Hamilton anxiety scale (HAMA) score, Hamilton depression scale (HAMD) score, complication rates and the nursing quality of the two groups were observed. Results: After multi-dimensional nursing combined with the GRACE in-hospital scoring system for stratified nursing in the study group, SF-36 scores in both groups increased after conventional nursing in the control group, but there was a statistical difference between the study group and the control group (p < 0.05). HAMA score and HAMD score decreased, and there were statistical differences between the study group and the control group (p < 0.05). The comparison between the study group and the control group showed that “Cardiac tamponade”, “Atrioventricular block”, “Peripheral vascular injury” and the total incidence of complications were statistically different (p < 0.05). The basic satisfaction, number of satisfaction and total satisfaction rate of the study group were higher than those of the control group, and the difference was statistically significant (p < 0.05). Conclusions: Multi-dimensional nursing combined with the GRACE scoring system in the nursing care of patients with atrial fibrillation after radiofrequency ablation with the green precision catheter, improves the quality of life, alleviates negative emotions, reduces the incidence of complications, and results in better quality of nursing care.