Patient with recurrence dermatofibrosarcoma protuberans: A case report

Amjadzadeh, Mohammadreza; Ghanavati, Parvin Mousavi

doi:10.1002/ccr3.2868

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…Localized recurrence of DFSP is common, with recurrence rates ranging from 10-60%; the risk of recurrence is elevated in cases where surgical resection margins are inadequate. This is primarily due to the microscopic finger-like, invasive protrusions that are often observed in DFSP, which may not be appreciated grossly during surgical resection [ 19 ]. Furthermore, since surgery and scar formation are risk factors for the development of DFSP, these may contribute to the increased risk of recurrence in patients with a prior history of the disease [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Breast Imaging Findings in Dermatofibrosarcoma Protuberans: A Case Report and Review of Literature

Pernicone¹,

Fábrega-Foster²

2022

Cureus

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Dermatofibrosarcoma protuberans (DFSP) is a rare, indolent, cutaneous sarcoma originating in the dermis, and although nearly half of cases occur on the trunk, DFSP of the breast is exceedingly rare, and imaging findings may resemble primary breast neoplasms. In this case report, a previously healthy, middle-aged female patient presented to the clinic with the complaint of abnormal growth in her left breast, which had been gradually increasing in size over the course of four years. Imaging of the left breast demonstrated a large, exophytic, partially intradermal mass with internal vascularity, raising concern for a primary breast neoplasm. Ultrasound-guided core needle biopsy revealed a diagnosis of DFSP. She underwent successful left skin-and nipple-sparing mastectomy with complete resection of the mass with negative margins confirmed on surgical pathology.Recognizing key features of DFSP on conventional breast imaging modalities, such as mammography and ultrasound, can be helpful in differentiating DFSP from primary breast neoplasms, but imaging findings alone may be nonspecific and biopsy is necessary for a definitive diagnosis. On mammography, DFSP typically presents as an exophytic, gently lobulated, non-calcified, and circumscribed mass. On sonographic examination, DFSP appears as a circumscribed, parallel-oriented mass that is hypoechoic relative to the surrounding fat, with intervening echogenic bands, posterior acoustic enhancement, and intralesional hypervascularity visualized on color Doppler. Although DFSP is slow-growing with a low incidence of metastatic disease, it has a high local recurrence rate and aggressive local resection is necessary to minimize the chance of recurrence.

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Section: Discussionmentioning

confidence: 99%

Breast Imaging Findings in Dermatofibrosarcoma Protuberans: A Case Report and Review of Literature

Pernicone¹,

Fábrega-Foster²

2022

Cureus

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“…The incidence is quite similar in women and men (4.4 vs 4.2% per million people per year) with a relative 5-year survival of 99.2% 4 . The most affected age group of DFSP is from 20 to 50 years 5 . The exact cause of the onset is not yet clearly understood.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Dermatofibrosarcoma Protuberans of the Clavicular Region: Radical Excision and Reconstruction With Latissimus Dorsi Myocutaneous Flap

Longo

D’Orsi

Orlando

et al. 2022

PRRS

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Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor with high propensity for local recurrence. We present a case of a 53-yearold woman with a recurrent DFSP of the clavicular region. The patient underwent extensive local excision including the external cortical bone of the left clavicle. The resulting large defect was reconstructed using pedicled Latissimus Dorsi myocutaneous flap. The histopathological examination confirmed dermatofibrosarcoma protuberans with clear surgical margins and the patient was satisfied with the final aesthetic result.

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“…However, DFSP grows in a locally aggressive pattern with a high rate of recurrence (20-50%). 2,3 Worse still, fibrosarcomatous transformation of DFSP (FS-DFSP) is a high-grade, more aggressive subtype with a higher risk of recurrence (55%), metastasis (10-15%, especially lymph nodes and the lung) and a worse prognosis. 4 Here, we report on a rare case of facial FS-DFSP with multiply local recurrences as well as lung and spine metastasis.…”

mentioning

confidence: 99%

“…Dermatofibrosarcoma protuberans is a rare malignant cutaneous sarcoma, which initially presents as an asymptomatic plaque with reddish-brown, pink or purple appearance, with gradual development of protuberant nodules within the plaque. 3 An accurate diagnosis depends on histopathological analysis. Spindle-shaped tumor cells that grow in a storiform pattern and often infiltrate subcutaneous fat to form a honeycomb appearance are the typical features.…”

mentioning

confidence: 99%

Facial fibrosarcomatous transformation of dermatofibrosarcoma protuberans with lung and spine metastasis

Cai

Jiang

2023

J Deutsche Derma Gesell

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Patient with recurrence dermatofibrosarcoma protuberans: A case report

Cited by 8 publications

References 5 publications

Breast Imaging Findings in Dermatofibrosarcoma Protuberans: A Case Report and Review of Literature

Breast Imaging Findings in Dermatofibrosarcoma Protuberans: A Case Report and Review of Literature

Recurrent Dermatofibrosarcoma Protuberans of the Clavicular Region: Radical Excision and Reconstruction With Latissimus Dorsi Myocutaneous Flap

Facial fibrosarcomatous transformation of dermatofibrosarcoma protuberans with lung and spine metastasis

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