Patients with More Severe IBD Get Clostridioides difficile Rather than Clostridioides difficile Increasing the Severity of IBD

How Infection with C. difficile Infection Aggravates Inflammatory Bowel Disease: Is It CDI or the CDAI?

“…In the present study, Varma et al [5] indicated that patients with prior CDI had a significantly shorter time to disease relapse and inferior outcomes compared with their CDI-negative counterparts, in which the presence of CDI was significantly associated with hospitalization at the time of the second IBD flare. These observations are in accordance with prior studies that have demonstrated the risk of poorer outcomes in IBD-CDI when compared with either condition alone [8].…”

“…In this issue of Digestive Diseases and Sciences, Varma and colleagues [5] retrospectively evaluated patients hospitalized for ≥ 2 IBD flares at New York-Presbyterian Columbia University Irving Medical Center from January 2010 to September 2019. The authors compared the time to IBD flare between patients who were hospitalized for a flare complicated by CDI and subsequently for a CDInegative flare (± ; cohort A) versus patients who were hospitalized for two CDI-negative flares (−/−; cohort B).…”