Patients With Penile Carcinoma Benefit From Immediate Resection of Clinically Occult Lymph Node Metastases

Kroon, Bin B. R.; Horenblas, Simon; Lont, A.P.; Tanis, Pieter J.; Gallee, M.P.W.; Nieweg, Omgo E.

doi:10.1097/01.ju.0000154565.37397.4d

Cited by 319 publications

(170 citation statements)

References 18 publications

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“…Identifying patients with occult metastases is important because it has been shown that immediate lymphadenectomy confers a survival advantage over surgery deferred until palpable disease develops (47,48). In a recent series of forty patients, the 3-year disease-specific survival of patients with metastatic nodes detected on surveillance was 35% versus 84% in those who underwent early resection (48). These numbers are very similar to those that have been reported with more extensive (6-7 year) follow-up (47).…”

Section: Assessment Of the Inguinal Nodessupporting

confidence: 69%

“…The staging modalities previously mentioned offer hope that this subgroup may be identified in a non-invasive manner in the near future. Identifying patients with occult metastases is important because it has been shown that immediate lymphadenectomy confers a survival advantage over surgery deferred until palpable disease develops (47,48). In a recent series of forty patients, the 3-year disease-specific survival of patients with metastatic nodes detected on surveillance was 35% versus 84% in those who underwent early resection (48).…”

Section: Assessment Of the Inguinal Nodesmentioning

confidence: 99%

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Update in the management of penile cancer

et al. 2009

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Purpose: The management of penile cancer has evolved as less invasive techniques are applied in the treatment of the primary tumor and inguinal lymph nodes. Materials and Methods: Herein we review the literature focusing on advances in the preservation of the phallus as well as less morbid procedures to evaluate and treat the groins. Results: Promising imaging modalities for staging are discussed. New techniques are described and tables provided for penile preservation. We also review the contemporary morbidity of modified surgical forms for evaluation of the inguinal nodes. Conclusions: Advances in surgical technique have made phallic preservation possible in a greater number of primary penile cancers. The groins can be evaluated for metastasis with greater accuracy through new radiologic means as well as with less morbid modified surgical techniques.

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Section: Assessment Of the Inguinal Nodessupporting

confidence: 69%

Section: Assessment Of the Inguinal Nodesmentioning

confidence: 99%

Update in the management of penile cancer

et al. 2009

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“…Different treatments were performed in similar clinical settings. These facts reflect the lack of standardization of the treatment of penile cancer nowadays, particularly in relation to lymph node involvement (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Objectives: To investigate and analyze the epidemiological profile of penile cancer in the state of Pernambuco and compare this information with other studies related to the issue. Material and Methods:We conducted a retrospective, observational and descriptive study of all patients with penile cancer in two reference centers in Pernambuco -Brazil, from 2007 to 2012. The variables studied were: age, region from the state, socio--economic situation, previous postectomy, smoking, time from the beginning of injury to diagnosis, staging of the primary lesion, tumor differentiation, treatment performed and death due to cancer. Results:The total number of patients was 88. The highest prevalence was seen in those aged between 66 and 75 years. About the socio-economic situation, 67% worked informally and 64.8% received up to two minimum wages. Of all patients, 57% were married and 50% illiterate. The Metropolitan Region of Recife was the one with the highest number of cases, 41%. Tobacco smoking was reported in 48.9% of cases and prior postectomy in 3.4%. Most often it was observed an average period of six months from the onset of symptoms to diagnosis. And when the lesion was diagnosed, it usually had 2 to 5 cm (64.7%), stage T2 in 50% and well differentiated in 79.6%. Partial penectomy was performed in 76.1% and total in 17%. Death was observed in 27.3%. Conclusion:The clinical profile and epidemiological characteristics found in this study are similar to other national and international studies related to the issue, i.e., typical of underdeveloped or developing countries.

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“…This apparent improvement in survival is in keeping with the reported benefits of early node surgery in high-risk cases. 2,3 The Improving Outcomes Guidance states that penis cancer should be treated in a supraregional centre serving a population of at least 4 million and treating 25 or more cases per year. Our referral population reached 3.1 million in 2005 and, at that time, we were referred an average of 20 patients annually.…”

Section: Discussionmentioning

confidence: 99%

The impact of Improving Outcomes Guidance on the management and outcomes of patients with carcinoma of the penis

Bayles

Sethia

2010

annals

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INTRODUCTION The Improving Outcomes Guidance (IOG) for patients with carcinoma of the penis states that treatment should be provided supraregionally to populations of 4 million or greater who treat over 25 cases of penis cancer each year. This study assesses the impact of this guidance on the management and outcomes of patients with the disease in our region. PATIENTS AND METHODS We retrospectively compared the records of 44 patients with carcinoma of the penis treated in our institution between 1969 and 1990 with 101 patients treated between 2002 and 2006, i.e. after supraregional centralisation of the service. RESULTS There was no significant change in the stage or grade of the tumours. However, the results show that, in modern times, there was a significant increase in the amount of penis-preserving and nodal surgery as well as a fall in mortality. The improved survival is greatest in patients with poorly-differentiated disease who may, therefore, have benefited from aggressive nodal surgery. CONCLUSIONS The centralisation of surgery for carcinoma of the penis results in improved outcomes both in terms of preservation and improved survival and this supports the IOG guidance.

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Patients With Penile Carcinoma Benefit From Immediate Resection of Clinically Occult Lymph Node Metastases

Abstract: Early resection of lymph node metastases in patients with penile carcinoma improves survival.

Cited by 319 publications

References 18 publications

Update in the management of penile cancer

Update in the management of penile cancer

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

The impact of Improving Outcomes Guidance on the management and outcomes of patients with carcinoma of the penis

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