Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand

Keorochana, Narumon

doi:10.1080/09273948.2019.1589527

Cited by 9 publications

(15 citation statements)

References 35 publications

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“…A retrospective study from the Uveitis Clinic at this institution also identified only 50 BD uveitis cases over a 10.5‐year period . However, reports involving 254‐758 uveitis patients from uveitis clinics of various tertiary medical centers in Thailand found the prevalence of BD uveitis at 6.72%‐15.54% . These findings suggested that BD in Thailand might not be as rare as initially believed.…”

Section: Discussionmentioning

confidence: 94%

“…A retrospective study from the Uveitis Clinic at this institution also identified only 50 BD uveitis cases over a 10.5-year period 28. However, reports involving 254-758 uveitis patients from uveitis clinics of various tertiary medical centers in Thailand found the prevalence of BD uveitis at 6.72%-15.54% [29][30][31]. These findings suggested that BD in Thailand might not be as rare as initially believed.One explanation might be that the majority of BD patients had ocular problems and therefore tended to visit an ophthalmologist, and if the extra-ocular manifestations were not considered during history tak-…”

mentioning

confidence: 93%

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Contribution of HLA‐B51:01 and ‐A26:01 to Behçet's disease and their clinical association in Thai patients

et al. 2020

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Aims To investigate susceptible human leukocyte antigen (HLA) alleles and their associations with clinical features in Thai patients with Behçet's disease (BD). Method Eighteen HLA‐A and 36 HLA‐B alleles were determined in 42 Thai BD patients and 99 healthy controls (HCs) by reverse line blot assay, and reconfirmed by MICRO SSP assay. Results The BD patients had significantly higher allele frequency (AF) of HLA‐B*51 than the HCs (13.10% vs 5.05%, P = .025). The AF of HLA‐A*26, ‐A*26:01 and ‐B*51:01 also was higher and almost reached statistical significance (5.59% vs 1.52%, P = .054, 5.95% vs 1.52%, P = .054 and 10.71% vs 4.04%, P = .051, respectively). However, the BD patients had significantly higher AF of either HLA‐A*26:01 or ‐B*51:01 (16.67% vs 5.56%, P = .005), or ‐A*26:01 or ‐B*51X (19.05% vs 6.56%, P = .003). The AF of HLA‐B*51:01 and ‐B*51X increased significantly in ‐A*26:01 non‐carrier BD patients (12.16% vs 4.17%, P = .024 and 14.86% vs 5.21%, P = .019, respectively); and that of HLA‐A*26:01 was significantly higher in ‐B*51X non‐carrier BD patients (7.58% vs 1.67%, P = .034). HLA‐B*51:01 associated significantly with the presence of posterior uveitis and visual impairment (18.18% vs 2.50%, P = .031 for both conditions). HLA‐B*51:01 was not observed in BD patients with gastrointestinal involvement or arthritis. Furthermore, the AF of HLA‐B*51:01 was significantly higher in HLA‐A*26:01 non‐carrier BD patients without arthritis (17.30% vs 0%, P = .050). Conclusion HLA‐B*51:01 was a susceptible allele for Thai BD patients, and associated with posterior uveitis and visual impairment. HLA‐A*26:01 was another susceptible allele in HLA‐B*51X non‐carrier patients. The protective effect of HLA‐B*51:01 on arthritis needs further investigation.

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 93%

Contribution of HLA‐B51:01 and ‐A26:01 to Behçet's disease and their clinical association in Thai patients

et al. 2020

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“…Our goal of reviewing these studies, it to update the knowledge on the incidence and prevalence of uveitis since 2019. Table 2 shows that the prevalence of uveitis varies from 12.4 per 100,000 persons in Portugal (19) to 580 per 100,000 persons in Thailand (22). Once again, these recent studies did not specifically focus on non-infectious uveitis, although most of the cases were of non-infectious etiology (18)(19)(20)(21)(22)(23).…”

Section: Incidence and Prevalence Worldwidementioning

confidence: 99%

“…It is unclear how many of these are non-infectious. From the recent Thailand study (22), acute uveitis represented more than half of cases (57.7%), which included 44% non-infectious and 36% idiopathic cases. Additional studies are needed to elucidate further epidemiologic trends in chronicity of noninfectious uveitis.…”

Section: Location Of Uveitis and Chronicitymentioning

confidence: 99%

“…Sex hormones, including estrogen, likely contribute to the differing immune response and susceptibility to development of autoimmune diseases, including uveitis, in women (30). Many studies worldwide found that males and females are equally affected by uveitis, however these studies included both infectious and non-infectious causes of uveitis (5,10,(18)(19)(20)(21)(22).…”

Section: Sexmentioning

confidence: 99%

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Epidemiology and Risk Factors in Non-infectious Uveitis: A Systematic Review

Joltikov

Lobo-Chan

2021

Front. Med.

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Purpose: Non-infectious uveitis is a leading cause of vision loss in the developed world. The purpose of this systematic review is to investigate the epidemiology and risk factors of non-infectious uveitis over the last 50 years.Methods: A systematic literature search of Pubmed/MEDLINE database was performed in the 50-year period from January 1971 to January 2021, according to the PRISMA guidelines. Studies that assessed the epidemiology and risk factors for non-infectious uveitis were included.Results: Few epidemiologic studies focus specifically on non-infectious uveitis. In the Unites States, the estimated prevalence of non-infectious uveitis is 121/100,000. The incidence and prevalence varies considerably worldwide. Females and the working age group (20–50 years) appear to be the most affected. Smoking and vitamin D deficiency are the biggest risk factors for non-infectious uveitis, while pregnancy appears to be protective. Additional risk factors include presence of other autoimmune diseases (thyroid disease, diabetes, celiac), pre-eclampsia/eclampsia, psychological stress, and certain medications (bisphosphonates, immune checkpoint inhibitors, female hormone therapy, and etanercept).Discussion: Our systematic review summarizes the incidence and prevalence of non-infectious uveitis and associated modifiable and non-modifiable risk factors.

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Characteristics and outcomes of the duration of treatment with adjunctive corticosteroids in intraocular tuberculosis

Ngathaweesuk,

Janthayanont,

Keorochana

2024

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand

Cited by 9 publications

References 35 publications

Contribution of HLA‐B51:01 and ‐A26:01 to Behçet's disease and their clinical association in Thai patients

Contribution of HLA‐B51:01 and ‐A26:01 to Behçet's disease and their clinical association in Thai patients

Epidemiology and Risk Factors in Non-infectious Uveitis: A Systematic Review

Characteristics and outcomes of the duration of treatment with adjunctive corticosteroids in intraocular tuberculosis

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Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand

Cited by 9 publications

References 35 publications

Contribution of HLA‐B*51:01 and ‐A*26:01 to Behçet's disease and their clinical association in Thai patients

Contribution of HLA‐B*51:01 and ‐A*26:01 to Behçet's disease and their clinical association in Thai patients

Epidemiology and Risk Factors in Non-infectious Uveitis: A Systematic Review

Characteristics and outcomes of the duration of treatment with adjunctive corticosteroids in intraocular tuberculosis

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Contribution of HLA‐B51:01 and ‐A26:01 to Behçet's disease and their clinical association in Thai patients

Contribution of HLA‐B51:01 and ‐A26:01 to Behçet's disease and their clinical association in Thai patients