Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases

Liu, Yan; He, Liyun; Wen, Tao; Yan, Shiyan; Bai, Wei; Liu, Baoyan

doi:10.1007/s11655-017-2420-1

Cited by 1 publication

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References 22 publications

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“…Moreover, other study has demonstrated that BNP and PCT levels can be an indicator of severe fatal HFMD. Although the pathogenesis of HFMD has not yet been fully clarified ( 15 ), it is related to the inhibition of immune function, especially cellular inhibition of immune function. Therefore, we conducted a retrospective study to analyze the relationship between the severity of HFMD and cellular immunity, age, and PCT and BNP levels.…”

Section: Discussionmentioning

confidence: 99%

The comparisons of procalcitonin and age between mild and severe Hand, foot, and mouth disease

Wang¹,

Zheng²,

Zhang³

2023

Transl Pediatr

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Background: Hand, foot, and mouth disease (HFMD) is an epidemic infectious disease in children, usually associated with fever, mouth lesions, and limb rashes. Although benign and self-limiting, it can be dangerous or even fatal in rare cases. Early identification of severe cases is crucial to ensure optimal care. Procalcitonin (PCT) is an early marker for predicting sepsis. Therefore, in this study, we aimed to investigate the significance of PCT levels, age, lymphocyte subsets, N-terminal pro-brain natriuretic peptide (BNP) in the early diagnosis of severe HFMD.Methods: Using strict inclusion and exclusion criteria, we retrospectively enrolled 183 children with HFMD between January 2020 and August 2021 and divided them into mild (76 cases) and severe (107 cases) groups according to their condition. Data on the patients' PCT levels, lymphocyte subsets, and clinical characteristics at admission were evaluated and compared using the Student's t-test and χ 2 test.Results: We found that compared with mild disease forms, the severe disease forms were associated with higher blood PCT levels (P=0.001) and lower ages of onset (P<0.001). The percentages of lymphocyte subsets, including suppressor T cells (CD3 + CD8 + ), T lymphocytes (CD3 + ), T helper cells (CD3 + CD4 + ), natural killer cells (CD16 + 56 + ), and B lymphocytes (CD19 + ), were identical between the two disease forms in patients under 3 years of age.Conclusions: Age and blood PCT levels play a vital role in the early identification of severe HFMD.

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Section: Discussionmentioning

confidence: 99%

The comparisons of procalcitonin and age between mild and severe Hand, foot, and mouth disease

Wang¹,

Zheng²,

Zhang³

2023

Transl Pediatr

View full text Add to dashboard Cite

show abstract

Pattern Classification of Enterovirus 71-Associated Hand, Foot, and Mouth Disease in Chinese Medicine: A Retrospective Study in 433 Cases

Abstract: LCA on reported symptoms and signs in a retrospective study allowed different subgroups with meaningful clinical correlates to be defined. These findings provide evidence for targeted prevention and treatment interventions.

Cited by 1 publication

References 22 publications

The comparisons of procalcitonin and age between mild and severe Hand, foot, and mouth disease

The comparisons of procalcitonin and age between mild and severe Hand, foot, and mouth disease

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