Pattern of histopathological lesions in lung autopsy

Abstract

Background: A large number of pathologic conditions involve the lung parenchyma like inflammatory, neoplastic and others. The lungs are also involved in almost all terminal events of cardiovascular disease. Autopsy is an important and most useful way to find out the condition of internal organs and to evaluate any localized lesions or systemic disease and hence determine cause of death. Aims and objectives of study are to identify the histopathological spectrum of lung disease. To find out frequency of various lung pathologies in respect to age and sex.Methods: This study was retrospective and done on 649 cases of medico legal autopsies. The tissue specimens were fixed and processed. Routine paraffin sectioning was done followed by Hematoxylene and eosin (H and E) staining. Special stains were done whenever required. Relevant clinical and postmortem findings, gross and microscopic examination findings were recorded.Results: After thorough histopathological examinations, of total 649 cases, various pulmonary lesions were identified in 348(53.6%) cases while in 301(46.4%) cases no significant pathology was seen. Most commonly affected age group was 30-49 years 43.1% followed by age group of >60years 17.8%. Majority of diseased were male 285 (81.9%). Most common lung pathology found was Edema and congestion in 93 cases (26.72%), chronic venous congestion in 92 cases (26.44%) pneumonia in 65 cases (18.68%) followed by Tuberculosis/Tuberculous pneumonia in 29 cases (8.3%).Conclusions: In our population, the present study reveals that infectious disease are still the most common cause of mortality, despite recent advances in diagnostic technology, the autopsy has remained an important complementary tool for identifying and understanding pathology of disease.

Autopsy study of spectrum of lung lesions in Tertiary care hospital

“…[ 12 ] and Chandani et al . [ 13 ] cases of emphysema were 6.5%, 8.9% and 4.3%. The reason we found is due to geographical variation of study population.…”

A Pathologist’s Perspective on Histopathology Examination of Autopsies and Various Incidental Findings

“…This is in agreement to study published by Kaur et al but in contrast to studies published by Arunlatha et al and Patel et al, showing pulmonary oedema as the m.c finding followed by CVS lung. [21,12,22] A case of fungal hyphae in lung was reported using PAS stain.…”

Spectrum Of Histopathological Lesions In Lungs At Medico Legal Autopsy: A Ten Years Study

“…Lungs are unique among all internal organs in that they are exposing themselves directly and constantly to the surrounding atmosphere and are important vital organ in human body [6]. They are vulnerable for a wide range of inflammatory, infectious and neoplastic conditions [6,7].…”

“…Lungs are unique among all internal organs in that they are exposing themselves directly and constantly to the surrounding atmosphere and are important vital organ in human body [6]. They are vulnerable for a wide range of inflammatory, infectious and neoplastic conditions [6,7]. Despite recent advances in diagnostic technology, pulmonary diseases are sometimes nonspecific, pathological examination gives exact cause of death and helps to correlate clinical scenario [8,9].…”

“…Despite recent advances in diagnostic technology, pulmonary diseases are sometimes nonspecific, pathological examination gives exact cause of death and helps to correlate clinical scenario [8,9]. Organ specific pathological changes that are seen during autopsy give a clear picture of the cause of death and help to correlate with clinical features [6,9]. cases of neoplastic lesions careful description of the appearance and extent of the tumour was done with particular reference to invasion of adjacent structures.…”